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Abstract

Heart base tumours (HBT) occur commonly in older, brachycephalic dogs. A presumptive diagnosis is made based on location and appearance of the tumour via echocardiogram. Effective treatment options are limited to surgery (when feasible) or radiation therapy. Benefit of medical management is...

Author(s)
Lew, F. H.; McQuown, B.; Borrego, J.; Cunningham, S.; Burgess, K. E.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2019, 17, 4, pp 465-471
Abstract

Inflammatory bowel disease (IBD) is a common gastrointestinal disease in dogs. Decreased production of intestinal immunoglobulin A (IgA) has been suggested as a possible pathogenesis in a subset of canine IBD; however, the underlying cause remains unclear. Sphingosine-1-phosphate (S1P) is a lipid...

Author(s)
Nakazawa, M.; Maeda, S.; Yokoyama, N.; Nakagawa, T.; Yonezawa, T.; Ohno, K.; Matsuki, N.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2019, 81, 9, pp 1249-1258
Abstract

Background: Effective treatment options for inoperable, metastatic, or recurrent canine pheochromocytomas are lacking. In humans, specific germline mutations exist that drive the development of pheochromocytomas. Pharmaceutical blockade of these abnormalities with small molecule inhibitors are an...

Author(s)
Musser, M. L.; Taikowski, K. L.; Johannes, C. M.; Bergman, P. J.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2018, 14, 272, pp (3 September 2018)
Abstract

In healthy individuals, plasma glucose levels are maintained within a normal range. During fasting, endogenous glucose is released either through glycogenolysis or gluconeogenesis. Gluconeogenesis involves the formation of glucose-6-phosphate from a variety of precursors followed by its subsequent...

Author(s)
Kanai, S.; Shimada, T.; Narita, T.; Okabayashi, K.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2019, 81, 10, pp 1515-1521
Abstract

Objective: An ideal disease modifying osteoarthritis drug (DMOAD) has chondroprotective, anti-inflammatory, and analgesic effects. This study describes the production and characterization of a canine IL4-10 fusion protein (IL4-10 FP) and evaluates its in vivo DMOAD activity in a canine model of...

Author(s)
Helvoort, E. M. van; Popov-Celeketic, J.; Eijkelkamp, N.; Coeleveld, K.; Tryfonidou, M. A.; Wijne, C. D.; Hack, C. E.; Lafeber, F. P. J. G.; Mastbergen, S. C.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2019, 14, 7, pp e0219587
Abstract

Canine insulinoma is a highly metastatic neoplasm that is associated with a guarded to poor prognosis in dogs with distant metastases. A median survival of 6 mo has been reported for dogs with metastatic insulinoma. The dog in this report, diagnosed with stage III pancreatic insulinoma, had...

Author(s)
Flesner, B. K.; Fletcher, J. M.; Smithee, T.; Boudreaux, B.
Publisher
American Animal Hospital Association, Denver, USA
Citation
Journal of the American Animal Hospital Association, 2019, 55, 1, pp e551-05
Abstract

Transitional cell carcinoma (TCC) is a locally aggressive tumor in dogs with low-to-moderate responses to traditional chemotherapeutic agents. Toceranib (TOC) phosphate represents a novel agent for the treatment of canine TCC. Thirty-seven dogs were identified who had received TOC for bladder tumor ...

Author(s)
Gustafson, T. L.; Biller, B.
Publisher
American Animal Hospital Association, Denver, USA
Citation
Journal of the American Animal Hospital Association, 2019, 55, 5, pp 243-248
AbstractFull Text

Fifty (50) microscopically diagnosed Babesia positive dogs were randomly divided into five treatment groups (B, C, D, E and F) with intention to comparatively evaluate the therapeutic efficacy of single drugs with combination therapy. Parameters were compared with healthy control group A. The dogs...

Author(s)
Baishya, B. C.; Phukan, A.; Mahato, G.; Goswami, S.; Kakati, P.
Publisher
Intas Pharmaceuticals Ltd, Ahmedabad, India
Citation
Intas Polivet, 2018, 19, 2, pp 249-253
Abstract

Phosphofructokinase-1 (PFK-1) is the most important rate-controlling enzyme for glycolysis in both prokaryotes and eukaryotes. PFK-1 activity is regulated by multiple cellular metabolites, including nucleotides. Intracellular nucleotides are produced through various metabolic processes, including...

Author(s)
Kanai, S.; Shimada, T.; Narita, T.; Okabayashi, K.
Publisher
Veterinary Solutions LLC, Apopka, USA
Citation
International Journal of Applied Research in Veterinary Medicine, 2019, 17, 1, pp 10-16
AbstractFull Text

Aim: The effect of citrate phosphate dextrose adenine-1 on the hematological parameters of stored Nigerian indigenous dog's blood with plastic vacutainer was investigated. This was done in view of determining the viability and stability of the studied parameters for blood banking purpose. Till...

Author(s)
Nnamdi, O. H.; Ijeoma, U. R.; Okaforx, N. T.
Publisher
Veterinary World, Wankaner, India
Citation
Veterinary World, 2019, 12, 3, pp 449-453

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