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Abstract

Mesenchymal stem cells (MSC) are a potential alternative source of differentiated chondrocytes for cartilage tissue regeneration and repair of osteoarthritic (OA) joints. We investigated the effects of pentosan polysulfate (PPS) and polysulfated glycosaminoglycan (PSGAG) on chondrogenesis of canine ...

Author(s)
Bwalya, E. C.; Kim SangHo; Fang Jing; Wijekoon, H. M. S.; Hosoya, K.; Okumura, M.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2017, 79, 7, pp 1182-1190
Abstract

Background: Sodium pentosan polysulfate (NaPPS) was testified as a chondroprotective drug in with a detailed rationale of the disease-modifying activity. This study was undertaken to determine whether anti-osteoarthritis drug, NaPPS inhibited osteoclasts (OC) differentiation and function. Canine...

Author(s)
Wijekoon, H. M. S.; Bwalya, E. C.; Fang Jing; Kim SangHo; Hosoya, K.; Okumura, M.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2018, 14, 152, pp (2 May 2018)
Abstract

Pentosan polysulfate sodium (PPS) has a heparin-like structure and is purificated from the plant of European beech wood. PPS has been used for the treatment of interstitial cystitis for human patients. Recent years, it was newly recognised that PPS reduce pain and inflammation of OA. The molecular...

Author(s)
Sunaga, T.; Oh NamGil; Hosoya, K.; Takagi, S.; Okumura, M.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2012, 74, 6, pp 707-711
Abstract

Objective - To evaluate the efficacy of pentosan polysulfate (PPS) for improving the recovery period and mitigate the progression of osteoarthritis (OA) of the canine stifle after extracapsular stabilization of cranial cruciate ligament (CCL) injuries. Study Design - Randomized, blinded,...

Author(s)
Budsberg, S. C.; Bergh, M. S.; Reynolds, L. R.; Streppa, H. K.
Publisher
Blackwell Publishing, Boston, USA
Citation
Veterinary Surgery, 2007, 36, 3, pp 234-244
AbstractFull Text

Osteoarthritis (OA) is the most common joint disease in both humans and animals, and it results in movement restriction and pain at the affected area. This disorder affects more than 25% of people over 60 years of age, and it is considered universal for 70-year-old people. OA is estimated to affect ...

Author(s)
Melo, M. M.; Mallmann, P. R.; Sonego, D. A.; Marques, A. T.; Gonçalves, G. F.; Zanatta, R.; Souza, M. A.; Néspoli, P. E. B.; Souza, R. L.
Publisher
Universidade Estadual de Londrina, Londrina, Brazil
Citation
Semina: Ciências Agrárias (Londrina), 2013, 34, 3, pp 1217-1226
Abstract

Objective - To document clinical outcomes after subtotal coronoid ostectomy (SCO) for treatment of medial coronoid disease (MCD). Study Design - Prospective clinical study. Animals - Dogs (n=263) with MCD. Methods - MCD was treated by a combination of SCO via mini-arthrotomy, cage confinement (6...

Author(s)
Fitzpatrick, N.; Smith, T. J.; Evans, R. B.; O'Riordan, J.; Yeadon, R.
Publisher
Blackwell Publishing, Boston, USA
Citation
Veterinary Surgery, 2009, 38, 2, pp 233-245
Abstract

One hundred and four dogs diagnosed with osteoarthritis (OA) were enrolled in a multicentric, double-blind, comparator controlled, randomized clinical study in Germany to establish the effect on the clinical signs of pain and lameness of the disease modifying anti-osteoarthritis drug (DMOAD) sodium ...

Author(s)
Brunnberg, L.; Smith, J. G.; Hannon, R. L.; Gebski, V.; Cullis-Hill, D.
Publisher
Verlag M. & H. Schaper, Alfeld (Leine), Germany
Citation
Kleintierpraxis, 2007, 52, 3, pp 133-142
Abstract

A four-year-old female Cavalier King Charles Spaniel with a history of recurrent lower urinary tract disease refractory to treatment was referred to our hospital. Clinical examination was unremarkable apart from thickening of the dorsal vulva. Abdominal ultrasound was compatible with possible areas ...

Author(s)
Sul, R. M.; Hammond, G.; Pratschke, K.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record Case Reports, 2014, 2, 1, pp e000106
Abstract

Objective - To identify and critically evaluate the quality of evidence of the most commonly used pharmacologic, nutraceutical, and purported slow-acting drugs of osteoarthritis for the management of osteoarthritis in dogs by use of the FDA's evidence-based medicine scoring system. Design -...

Author(s)
Aragon, C. L.; Hofmeister, E. H.; Budsberg, S. C.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2007, 230, 4, pp 514-521
Abstract

The efficacy of calcium pentosan polysulphate (CaPPS) as a slow-acting drug for the treatment of osteoarthritis of the canine stifle joint, secondary to cranial cruciate ligament deficiency, was tested in a double-blind, placebo-controlled clinical trial over a period of 1 year. Dogs with the...

Author(s)
Innes, J. F.; Barr, A. R. S.; Sharif, M.
Citation
Veterinary Record, 2000, 146, 15, pp 433-437

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