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Abstract

Background: T-zone lymphoma (TZL), an indolent disease in older dogs, comprises approximately 12% of lymphomas in dogs. TZL cells exhibit an activated phenotype, indicating the disease may be antigen-driven. Prior research found that asymptomatic aged Golden Retrievers (GLDRs) commonly have...

Author(s)
Labadie, J. D.; Magzamen, S.; Morley, P. S.; Anderson, G. B.; Yoshimoto, J.; Avery, A. C.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2019, 33, 2, pp 764-775
Abstract

Background: Evolution of indolent to aggressive lymphoma has been described in dogs but is difficult to distinguish from the de novo development of a second, clonally distinct lymphoma. Differentiation of these scenarios can be aided by next generation sequencing (NGS)-based assessment of clonality ...

Author(s)
Matsuyama, A.; Bienzle, D.; Richardson, D.; Deravi, N.; Hwang MeiHua; Darzentas, N.; Keller, S. M.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2019, 15, 413, pp (16 November 2019)
Abstract

Canine T-zone lymphoma (TZL) is a subtype of T-cell lymphoma characterized by unique histologic pattern and cytomorphology, immunophenotypic loss of CD45 expression, and an indolent clinical behaviour. Dogs with TZL typically present with 1 or more enlarged lymph nodes and/or lymphocytosis. We...

Author(s)
Harris, L. J.; Rout, E. D.; Hughes, K. L.; Labadie, J. D.; Boostrom, B.; Yoshimoto, J. A.; Cannon, C. M.; Avery, P. R.; Ehrhart, E. J.; Avery, A. C.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2018, 16, 1, pp 131-139
Abstract

Published studies, taken together, suggest the existence of a single canine lymphoma entity, with a small clear cell appearance by cytological evaluation, a histopathological T-zone pattern and an aberrant CD45-negative T-cell phenotype, mostly characterized by long-term survival. We describe...

Author(s)
Martini, V.; Marconato, L.; Poggi, A.; Riondato, F.; Aresu, L.; Cozzi, M.; Comazzi, S.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2016, 14, s1, pp 117-126
Abstract

A 9-year-old, spayed female Golden Retriever dog was referred to us for lymphocytosis and lymphadenopathy, secondary to suspected chronic lymphocytic leukemia (CLL). The dog had a clinical history of anorexia, vomiting and melena lasting two days. The popliteal lymph node contained...

Author(s)
Suwa, A.; Shimoda, T.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2017, 79, 4, pp 736-739
Abstract

Clinical and histopathological characteristics of 16 dogs with nodal paracortical (T-zone) lymphoma (TZL) were evaluated. At initial examination, generalized lymphadenopathy was found in all dogs, and peripheral lymphocytosis was found in 10 of the 16 dogs. At initial diagnosis or during the...

Author(s)
Mizutani, N.; Goto-Koshino, Y.; Takahashi, M.; Uchida, K.; Tsujimoto, H.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2016, 78, 8, pp 1237-1244
Abstract

T zone lymphoma (TZL) is characterized by the clonal expansion of T cells lacking expression of the pan-leukocyte antigen CD45 (TZ cells). A strong breed predisposition is observed in Golden retrievers. This study aimed to confirm aberrant CD45 mRNA expression and determine if Golden retrievers...

Author(s)
Hughes, K. L.; Labadie, J. D.; Yoshimoto, J. A.; Dossey, J. J.; Burnett, R. C.; Avery, A. C.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2018, 16, 1, pp E109-E116
Abstract

Background: Canine T-cell lymphoma (TCL) is clinically and histologically heterogeneous with some forms, such as T-zone lymphoma (TZL), having an indolent course. Immunophenotyping is an important tool in the classification of TCL in people, and can be equally useful in dogs. Hypothesis/Objectives: ...

Author(s)
Seelig, D. M.; Avery, P.; Webb, T.; Yoshimoto, J.; Bromberek, J.; Ehrhart, E. J.; Avery, A. C.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2014, 28, 3, pp 878-886
Abstract

A 9-year-old spayed female Curly Coated Retriever was referred for evaluation of generalized peripheral lymphadenomegaly. The dog was clinically healthy on presentation with no anomalies detected on complete blood count, serum biochemistry, urinalysis, or three-view thoracic radiographs....

Author(s)
Parachini-Winter, C.; Curran, K. M.; Russell, D. S.; Gorman, E.
Publisher
Wiley, Boston, USA
Citation
Veterinary Clinical Pathology, 2018, 47, 4, pp 643-648
Abstract

Canine T-zone lymphoma (TZL) is a peculiar lymphoma subtype characterized by an indolent clinical course and aberrant CD45-negative phenotype, commonly recognized by flow cytometry (FC). Recent studies have described clinical presentation and behavior, but to date the mechanisms behind the loss of...

Author(s)
Martini, V.; Cozzi, M.; Aricò, A.; Rovere, G. dalla; Poggi, A.; Albonico, F.; Mortarino, M.; Ciusani, E.; Aresu, L.; Comazzi, S.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2017, 187, pp 14-19

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