Swine enteric diseases have caused significant economic loss and have been considered as the major threat to the global swine industry. Several coronaviruses, including transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV), have been identified as the causative...
Author(s)
Luo Lei; Wang ShaoHua; Zhu Lin; Fan BaoChao; Liu Tong; Wang LeFeng; Zhao PanPan; Dang YanNa; Sun Pei; Chen JianWen; Zhang YunHai; Chang XinJian; Yu ZhengYu; Wang HuaNan; Guo RongLi; Li Bin; Zhang Kun
Publisher
Nature Publishing Group, London, UK
Citation
Scientific Reports, 2019, 9, 1, pp 13186
Porcine epidemic diarrhoea is caused by the porcine epidemic diarrhoea virus, and is a highly contagious disease which affects the intestines of new-born piglets resulting in intense diarrhoea. Historically, the virus has caused enormous economic losses in the pig industry. In particular, the...
Author(s)
Ding, S. J.; Luo, Y. R.; Zhou, S. T.; Xie, C.; Wang, K.; Xie, Y. Y.; Cui, L.; Hua, X. G.; Yuan, C. L.; Zhou, Y. J.; Yang, Z. B.
Publisher
Czech Academy of Agricultural Sciences, Prague, Czech Republic
Citation
Veterinární Medicína, 2018, 63, 10, pp 468-475
Immunization with an insect cell lysate/baculovirus mixture containing recombinant porcine epidemic diarrhea virus (PEDV) spike protein induced high levels of neutralizing antibodies in both mice and piglets. However, immunization of piglets with this vaccine resulted in enhancement of disease...
Author(s)
Yu JieShi; Sreenivasan, C.; Uprety, T.; Gao RongYuan; Huang Chen; Lee, E. J.; Lawson, S.; Nelson, J.; Christopher-Hennings, J.; Kaushik, R. S.; Nelson, E.; Diel, D. G.; Hause, B. M.; Li Feng; Wang Dan
Publisher
Nature Publishing Group, London, UK
Citation
npj Vaccines, 2021, 6, 22,
Tripartite motif protein 21 (TRIM21) is an E3 ubiquitin ligase and cytosolic antibody receptor of the TRIM family. Previous reports have indicated that TRIM21 plays an important role during viral infection. This study aimed at examining the role of TRIM21 in the replication of porcine epidemic...
Author(s)
Wang Hua; Chen XiaoYong; Kong Ning; Jiao YaJuan; Sun DaGe; Dong SuJie; Qin WenZhen; Zhai HuanJie; Yu LingXue; Zheng Hao; Tong Wu; Yu Hai; Tong GuangZhi; Shan TongLing
Publisher
Springer-Wien, Vienna, Austria
Citation
Archives of Virology, 2021, 166, 7, pp 1903-1911
Porcine epidemic diarrhea virus (PEDV) is an enteric pathogen belonging to the family Coronaviridae that causes the porcine epidemic diarrhea, a highly contagious disease with high mortality in piglets and symptoms that include dehydration and severe diarrhea. Considering the high frequency of...
Author(s)
Yu XiangLong; Liu JianXin; Li HuiZi; Liu BoYang; Zhao BingQian; Ning ZhangYong
Publisher
Springer-Wien, Vienna, Austria
Citation
Archives of Virology, 2021, 166, 1, pp 157-165
Porcine epidemic diarrhea virus (PEDV) is an α-coronavirus causing severe diarrhea and high mortality rates in suckling piglets and posing significant economic impact. PEDV replication is completed and results in a large amount of RNA in the cytoplasm. Stress granules (SGs) are dynamic cytosolic...
Author(s)
Sun LiuMei; Chen Huan; Ming Xin; Bo ZongYi; Shin HyunJin; Jung YongSam; Qian YingJuan
Publisher
American Society for Microbiology (ASM), Washington, D.C., USA
Citation
Journal of Virology, 2021, 95, 9, pp e02344-20-e02344-20
Porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PDCoV) have emerged and spread throughout the porcine industry in many countries and are economically important pathogens causing diarrhea in sows and acute death in newborn piglets. Therefore, a sensitive diagnostic method would...
Author(s)
Li Gen; Wu MiaoLi; Li JinHui; Cai WeiYou; Xie YongSheng; Si GuangBing; Xiao Li; Cong Feng; He DongSheng
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Journal of Virological Methods, 2021, 292,
The genomes of coronaviruses carry accessory genes known to be associated with viral virulence. The single accessory gene of porcine epidemic diarrhea virus (PEDV), ORF3, is dispensable for virus replication in vitro, while viral mutants carrying ORF3 truncations exhibit an attenuated phenotype of...
Author(s)
Si FuSheng; Hu XiaoXia; Wang ChenYang; Chen BingQing; Wang RuiYang; Dong ShiJuan; Yu RuiSong; Li Zhen
Publisher
MDPI AG, Basel, Switzerland
Citation
Viruses, 2020, 12, 2,
Regional surveillance is important for detecting the incursion of new pathogens and informing disease monitoring and control programs. Modeling disease distribution over time can provide insight into the development of more efficient regional surveillance approaches. Herein we propose a Bayesian...
Author(s)
Ji, J.; Wang, C.; Rotolo, M.; Zimmerman, J.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Preventive Veterinary Medicine, 2020, 181,
Porcine Epidemic Diarrhea Virus (PEDV) causes severe diarrhea and mortality in piglets. Robust immunity may break the transmission cycle. Expression of antigens in maize grains is a promising method for producing low-cost vaccines. As a first step, we expressed maize constructs containing PEDV S1...
Author(s)
Egelkrout, E.; Hayden, C.; Fake, G.; Keener, T.; Arruda, P.; Saltzman, R.; Walker, J.; Howard, J.
Publisher
Springer, Dordrecht, Netherlands
Citation
Plant Cell, Tissue and Organ Culture, 2020, 142, 1, pp 79-86