Study reports new approach to salt reduction

DOCA-salt and obesity-related hypertension are associated with inflammation and sympathetic nervous system hyperactivity. Prejunctional α₂-adrenergic receptors (α₂ARs) provide negative feedback to norepinephrine release from sympathetic nerves through inhibition of N-type Ca²⁺ channels. Increased...

Background and aims: Previous studies suggest that olfactory receptors, which mediate smell chemosensation, are located in the kidney and involved in blood pressure regulation. Mammalian epithelial sodium channels located in taste receptor cells are also found to participate in blood pressure...

Objective: In the kidney disease clinic setting, higher-than-usual blood pressure is often ascribed to recent dietary sodium indiscretion. While clinical trials demonstrate a clear relationship between salt intake and blood pressure on the population level, it is uncertain whether real-world...

The impact of water intake has been studied in several renal diseases. For example, increasing water intake is useful to prevent primary and secondary nephrolithiasis. In autosomal dominant polycystic kidney disease, arginine vasopressin (AVP) is involved in the progression of the disease, and...

Background: We have previously reported that epoxyeicosatrienoic acid (EET) has multiple beneficial effects on renal and adipose tissue function, in addition to its vasodilatory action; it increases insulin sensitivity and inhibits inflammation. In an examination of the signaling mechanisms by...

Objective: To explore the effects of bitter taste sensitivity on salt intake and cardiac remodeling in hypertensive patients. Methods: Totally 164 in-patients with hypertension were enrolled and their physiological and biochemical indexes were measured. The averaged daily salt intake was calculated ...

There have been few studies investigating interactions of G-protein beta3 subunit (GNB3) C825T (rs5443) and dietary sodium intake on the risk of hypertension, i.e., BP salt sensitivity. The study aims to evaluate joint effects of GNB3 polymorphisms and sodium consumption on the development of ...

The present study is designed for the assessment of various pathological changes like immunoglobins, C-reactive protein, vitamin D, sodium, potassium, calcium in stress-induced hypertensive rats. Albino Wistar rats of sex male were grouped into six. Each group consists of six animals. Groups were...

Introduction: Non-communicable diseases (NCDs) contribute to 65% of all the deaths and 80% of these are in developing countries. Medical colleges have a large workforce with risk for NCDs similar to general population. Methodology: A cross-sectional survey among the 65 of 88 nonteaching staff...