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Abstract

Human carbonic anhydrase IX (CA IX) is upregulated in neoplastic tissues; as such, it is studied as a drug target for anticancer chemotherapy. Inhibition of CA IX has been shown to be therapeutically favorable in terms of reducing tumor growth. Previously, saccharin, a commonly used artificial...

Author(s)
Murray, A. B.; Lomelino, C. L.; Supuran, C. T.; McKenna, R.
Publisher
American Chemical Society, Washington, USA
Citation
Journal of Medicinal Chemistry, 2018, 61, 3, pp 1176-1181
Abstract

This study assessed the potential adverse health effects of long-term low-dose exposure to chemical mixtures simulating complex real-life human exposures. Four groups of Sprague Dawley rats were administered mixtures containing carbaryl, dimethoate, glyphosate, methomyl, methyl parathion,...

Author(s)
Docea, A. O.; Gofita, E.; Goumenou, M.; Calina, D.; Rogoveanu, O.; Varut, M.; Olaru, C.; Kerasioti, E.; Fountoucidou, P.; Taitzoglou, I.; Zlatian, O.; Rakitskii, V. N.; Hernandez, A. F.; Kouretas, D.; Tsatsakis, A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Food and Chemical Toxicology, 2018, 115, pp 470-481
Abstract

Dihydrochalcones, beneficial phenolic compounds, are abundant in Malus Mill. species, particularly in vegetative tissues and seeds. Phloridzin (phloretin 2′-O-glucoside) is the primary dihydrochalcone in most Malus species including cultivated apple, Malus × domestica Borkh. A few species contain...

Author(s)
Gutierrez, B. L.; Zhong GanYuan; Brown, S. K.
Publisher
Springer, Dordrecht, Netherlands
Citation
Genetic Resources and Crop Evolution, 2018, 65, 5, pp 1485-1502
Abstract

Aspartame (α-aspartyl-l-phenylalanine-o-methyl ester), an artificial sweetener, has been linked to behavioral and cognitive problems. Possible neurophysiological symptoms include learning problems, headache, seizure, migraines, irritable moods, anxiety, depression, and insomnia. The consumption of ...

Author(s)
Choudhary, A. K.; Lee YeongYeh
Publisher
Taylor & Francis, Abingdon, UK
Citation
Nutritional Neuroscience, 2018, 21, 5, pp 306-316
Abstract

The thermal properties of low fat, and low fat and sugar ice cream formulations, in which agave fructans were used as a sugar and fat, were evaluated by Modulated Differential Scanning Calorimetry. Approximately 3.0 g/100 mL of agave fructans promoted a positive effect on thermal properties for...

Author(s)
Pintor-Jardines, A.; Arjona-Román, J. L.; Totosaus-Sánchez, A.; Severiano-Pérez, P.; González-González, L. R.; Escalona-Buendia, H. B.
Publisher
Elsevier Ltd, Oxford, UK
Citation
LWT - Food Science and Technology, 2018, 93, pp 679-685
Abstract

The antimicrobial potential of three functional ingredients, açaí (Euterpe oleracea), stevia (Stevia rebaudiana Bertoni), and ginseng (Panax quinquefolius L.), was assessed against sporeforming/non-sporeforming foodborne pathogens before and after processing. In vitro inhibitory effect of tested...

Author(s)
Pina-Pérez, M. C.; Rivas, A.; Martínez, A.; Rodrigo, D.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Food Control, 2018, 90, pp 98-104
Abstract

This research investigated the intakes of six intense sweeteners: acesulfame-K (E950), aspartame (E951), cyclamate (E952), saccharin (E954), sucralose (E955), and steviol glycosides (E960) in the diets of Irish adults, using data from the National Adult Nutrition Survey. A food label survey that...

Author(s)
Buffini, M.; Goscinny, S.; Loco, J. van; Nugent, A. P.; Walton, J.; Flynn, A.; Gibney, M. J.; McNulty, B. A.
Publisher
Taylor & Francis, Abingdon, UK
Citation
Food Additives and Contaminants A, 2018, 35, 3, pp 425-438
Abstract

Reducing sugar consumption is an important aspect in the prevention of and fight against obesity. A broader understanding of consumers' perceptions of low-calorie sweeteners is needed. This study examined two low-calorie sweeteners, tagatose and stevia, in comparison to sugar in dark chocolate. A...

Author(s)
Lagast, S.; Steur, H. de; Schouteten, J. J.; Gellynck, X.
Publisher
Taylor & Francis, Abingdon, UK
Citation
International Journal of Food Sciences and Nutrition, 2018, 69, 3, pp 344-357
Abstract

Availability of reduced sugar gluten-free (GF) muffins remains commercially limited. In this study, selected physical properties, consumer perception and effects of health benefit information (HBI) were investigated for three GF muffins made with different amounts of sucrose (0%, 50%, 100%), with ...

Author(s)
Wardy, W.; Jack, A. R.; Chonpracha, P.; Alonso, J. R.; King, J. M.; Prinyawiwatkul, W.
Publisher
Wiley, Oxford, UK
Citation
International Journal of Food Science & Technology, 2018, 53, 1, pp 262-269
Abstract

Compared with other carbohydrates, fructose-containing caloric sweeteners (sucrose, high-fructose corn syrup, pure fructose and fructose-glucose mixtures) are characterized by: a sweet taste generally associated with a positive hedonic tone; specific intestinal fructose transporters, i.e. GLUT5; a...

Author(s)
Tappy, L.
Publisher
Company of Biologists Ltd, Cambridge, UK
Citation
Journal of Experimental Biology, 2018, 221, Suppl. 1, pp 164202

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