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Abstract

In the 1930's and 1940's, vitamin D was reported to be an effective treatment for a number of diseases, including asthma, psoriasis, rheumatoid arthritis, rickets and tuberculosis. High doses were used, 60,000 to 300,000 IU a day for asthma, and 200,000 to 600,000 IU a day for rheumatoid arthritis. ...

Author(s)
McCullough, P.; Amend, J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Steroid Biochemistry and Molecular Biology, 2017, 173, pp 308-312
Abstract

Inflammation-induced heat shock proteins (HSPs) and hypovitaminosis D have been reported to impact immune responses and to be associated with autoimmune diseases including celiac disease (CD), a gluten-sensitive enteropathy mediated by autoantibodies against tissue transglutaminase (TG2). Recently, ...

Author(s)
Tukaj, S.; Görög, A.; Kleszczyński, K.; Zillikens, D.; Kárpáti, S.; Kasperkiewicz, M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Steroid Biochemistry and Molecular Biology, 2017, 173, pp 23-27
Abstract

Objectives: We investigated the effects of 1,25-dihydroxy vitamin D3 (1,25(OH)2D3), i.e. biologically active vitamin D and calcipotriol, a vitamin D analog, on growth and secretion of inflammatory mediators in synovial stromal cells (SSC) of patients with rheumatoid arthritis (RA) or osteoarthritis ...

Author(s)
Huhtakangas, J. A.; Veijola, J.; Turunen, S.; Karjalainen, A.; Valkealahti, M.; Nousiainen, T.; Yli-Luukko, S.; Vuolteenaho, O.; Lehenkari, P.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Steroid Biochemistry and Molecular Biology, 2017, 173, pp 13-22
Abstract

Vitamin D is a modulator of both the innate and adaptive immune system. As vitamin D deficiency was a risk factor for some autoimmune diseases, we aimed to evaluate the serum vitamin D levels in autoimmune thyroid diseases (AITD) including Graves' disease (GD) and Hashimoto's thyroiditis (HT) and...

Author(s)
Ke WenCai; Sun TianGe; Zhang YaNan; He LeQi; Wu Qiang; Liu Jun; Zha BingBing
Publisher
Japan Endocrine Society, Kyoto, Japan
Citation
Endocrine Journal, 2017, 64, 6, pp 581-587
Abstract

Objective: To utilize Mendelian randomization to estimate the causal association between low serum vitamin D concentrations, increased body mass index (BMI), and pediatric-onset multiple sclerosis (MS) using genetic risk scores (GRS). Methods: We constructed an instrumental variable for vitamin D...

Author(s)
Gianfrancesco, M. A.; Stridh, P.; Rhead, B.; Shao XiaoRong; Xu, E.; Graves, J. S.; Chitnis, T.; Waldman, A.; Lotze, T.; Schreiner, T.; Belman, A.; Greenberg, B.; Weinstock-Guttman, B.; Aaen, G.; Tillema, J. M.; Hart, J.; Caillier, S.; Ness, J.; Harris, Y.; Rubin, J.; Candee, M.; Krupp, L.; Gorman, M.; Benson, L.; Rodriguez, M.; Mar, S. (et al)
Publisher
Lippincott Williams & Wilkins, Philadelphia, USA
Citation
Neurology, 2017, 88, 17, pp 1623-1629
Abstract

Objective: As previous research has suggested that exposure to vitamin D insufficiency in utero may have relevance for the risk of multiple sclerosis (MS), we aimed to examine the direct association between level of neonatal vitamin D and risk of MS. Methods: We carried out a matched case-control...

Author(s)
Nielsen, N. M.; Munger, K. L.; Koch-Henriksen, N.; Hougaard, D. M.; Magyari, M.; Jørgensen, K. T.; Lundqvist, M.; Simonsen, J.; Jess, T.; Cohen, A.; Stenager, E.; Ascherio, A.
Publisher
Lippincott Williams & Wilkins, Philadelphia, USA
Citation
Neurology, 2017, 88, 1, pp 44-51
Abstract

Background: Vitiligo is an acquired multifactorial disorder. Different treatments are used for it and all of them have adverse side-effects. Vitiligo is an autoimmune disease associated with other autoimmune diseases such as hypothyroidism, hyperthyroidism, rheumatoid arthritis, diabetes mellitus,...

Author(s)
Iraji, F.; Haftbaradaran, E.; Davashi, S.; Zolfaghari-Baghbaderani, A.; Bokaii-Jazi, S.
Publisher
Isfahan University of Medical Sciences, Isfahan, Iran
Citation
Journal of Isfahan Medical School, 2017, 34, 416, pp 1699-1705
Abstract

Background: Rheumatoid arthritis is a chronic, progressive inflammatory disease that causes pain, stiffness, swelling and destruction of the articular tissues. This study aimed to evaluate the relationship between serum levels of vitamin D and disease severity in patients with rheumatoid arthritis. ...

Author(s)
Noroozi, M.; Gholamzadeh-Baeis, M.
Publisher
Isfahan University of Medical Sciences, Isfahan, Iran
Citation
Journal of Isfahan Medical School, 2017, 34, 405, pp 1311-1317
Abstract

Background: The cause of Multiple Sclerosis (MS) remains poorly understood, but it is widely believed to be an autoimmune disease occurring in genetically susceptible individuals after exposure to as-yet undefined environmental factors. One of these environmental factors is vitamin D, a well-known...

Author(s)
Bettencourt, A.; Boleixa, D.; Guimarães, A. L.; Leal, B.; Carvalho, C.; Brás, S.; Samões, R.; Santos, E.; Costa, P. P.; Silva, B.; Silva, A. M. da
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Neuroimmunology, 2017, 309, pp 34-37
Abstract

Background: Vitamin D serum levels and the presence and activity of rheumatic conditions have been associated. However, many studies are merely observational, and the existent randomized clinical trials were never systematically analyzed. Therefore, this study aims to provide a systematic review...

Author(s)
Franco, A. S.; Freitas, T. Q.; Bernardo, W. M.; Pereira, R. M. R.
Publisher
Lippincott Williams & Wilkins, Inc., Hagerstown, USA
Citation
Medicine (Baltimore), 2017, 96, 23, pp e7024

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