The main etiological mechanism for Kashin-Beck disease (KBD) is deep chondrocyte necrosis induced by environmental risk factors (ERFs). The scholars have conducted several epidemiological, cellular, and animal model studies on ERFs. Gradually, four etiological hypotheses have been formed, including ...
Author(s)
Yu FangFang; Zuo Juan; Sun Lei; Yu ShuiYuan; Lei XiaoLi; Zhu JunHua; Zhou GuoYu; Guo Xiong; Ba Yue
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Ecotoxicology and Environmental Safety, 2022, 234,
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the tolerable upper intake level (UL) for vitamin B6. Systematic reviews of the literature were conducted by a contractor. The...
Author(s)
Turck, D.; Bohn, T.; Castenmiller, J.; Henauw, S. de; Hirsch-Ernst, K. I.; Knutsen, H. K.; Maciuk, A.; Mangelsdorf, I.; McArdle, H. J.; Pelaez, C.; Pentieva, K.; Siani, A.; Thies, F.; Tsabouri, S.; Vinceti, M.; Fairweather-Tait, S.; Vrolijk, M.; Fabiani, L.; Titz, A.; Naska, A.
Publisher
Wiley, Oxford, UK
Citation
EFSA Journal, 2023, 21, 5,
Safrole, a 162.2 Da natural compound belonging to the alkenylbenzenes class, is classified as a possible carcinogen to humans by IARC (group IIB) and has proven to be genotoxic and carcinogenic to rodents. Despite its use as a food or feed additive, it is forbidden in many countries due to its...
Author(s)
Pedroni, L.; Louisse, J.; Punt, A.; Dorne, J. L. C. M.; Dall'Asta, C.; Dellafiora, L.
Publisher
MDPI AG, Basel, Switzerland
Citation
Toxins, 2023, 15, 2,
Use of nano-sized materials to design novel delivery systems is actually a double-edged sword regarding the enhancement of absorption and bioavailability of encapsulated bioactives as well as the unpredictable phenomena inside the living cells causing health concerns. So, comprehensive...
Author(s)
Akbari-Alavijeh, S.; Shaddel, R.; Jafari, S. M.
Publisher
Taylor & Francis, Philadelphia, USA
Citation
Critical Reviews in Food Science and Nutrition, 2022, 62, 27, pp 7460-7478
Gamma-amino butyric acid (GABA) is marketed in the U.S. as a dietary supplement. USP conducted a comprehensive safety evaluation of GABA by assessing clinical studies, adverse event information, and toxicology data. Clinical studies investigated the effect of pure GABA as a dietary supplement or as ...
Author(s)
Oketch-Rabah, H. A.; Madden, E. F.; Roe, A. L.; Betz, J. M.
Publisher
MDPI AG, Basel, Switzerland
Citation
Nutrients, 2021, 13, 8,
Context: There is no licensed oral native testosterone (NT) because of challenges in the formulation. Licensed oral formulations of the ester, testosterone undecanoate (TU), require a meal for absorption and generate supraphysiological dihydrotestosterone (DHT) levels. Objective: To develop an oral ...
Author(s)
Newell-Price, J.; Huatan, H.; Quirke, J.; Porter, J.; Daniel, E.; Mumdzic, E.; Voet, B.; Keevil, B.; Whitaker, M. J.; Ross, R. J.
Publisher
BioScientifica Ltd, Bristol, UK
Citation
European Journal of Endocrinology, 2021, 185, 5, pp 607-615
Author(s)
Schoeniger, A.; Fuhrmann, H.; Adler, N.
Publisher
DLG-Verlag, Frankfurt am Main, Germany
Citation
Proceedings of the Society of Nutrition Physiology, 2017, 26, pp 152
Cilostazol (CLZ) is categorized as a biopharmaceutical classification system (BCS) class II drug. CLZ suspensions of jet-milled particles were orally administered to beagle dogs in fasted and fed states, for which food was given 0.5 h before the experiment. The mean highest concentration of CLZ (C...
Author(s)
Miyake, M.; Oka, Y.; Mukai, T.
Publisher
Taylor & Francis, Abingdon, UK
Citation
Xenobiotica, 2020, 50, 2, pp 232-236
It is believed that extracts of green tea increase fluoride uptake in deciduous enamel and the aim of this in vitro study was to evaluate the fluoride uptake in the enamel of primary teeth after using different concentrations of an extract of green tea. Seventy-five enamel samples were prepared...
Author(s)
Mohammadi, F.; Horri, A.; Poureslami, P.; Poureslami, H.; Mahvi, A. H.
Publisher
International Society of Fluoride Research, Ann Arbor, USA
Citation
Fluoride, 2020, 53, 2 Part 1, pp 268-275
It can be difficult to identify health/functional foods that exert therapeutic benefits for alleviating gingivitis and periodontitis. Recently, extracts of Boesenbergia pandurata (Roxb.), which is a tropical plant, have shown promising inhibitory activity against lipopolysaccharide-induced...
Author(s)
Choi Seungmok; Kim Changhee; Son Heebin; Hwang JaeKwan; Kang Wonku
Publisher
Mary Ann Liebert, Inc., New Rochelle, USA
Citation
Journal of Medicinal Food, 2020, 23, 4, pp 453-458