Toxoplasmosis is an infection caused by Toxoplasma gondii, the transmission of which has usually been attributed to ingestion of undercooked or raw meat. Epidemiological studies also mention cured meat products as a potential risk factor for acquiring toxoplasmosis. With the aim of contributing to...

Cachexia is a life-threatening disease characterized by chronic, inflammatory muscle wasting and systemic metabolic impairment. Despite its high prevalence, there are no efficacious therapies for cachexia. Mice chronically infected with the protozoan parasite Toxoplasma gondii represent a novel ...

Toxoplasma gondii is a worldwide food-borne parasite that can infect almost all warm-blooded animals, including humans. To date, there are no effective drugs to prevent or eradicate T. gondii infection. Recent studies have shown that probiotics could influence the relationship between the...

Recent progress indicates that the gut microbiota plays important role in regulating the host's glucose homeostasis. However, the mechanisms remain unclear. Here, we reported that one integral member of the murine gut microbiota, the protozoan Tritrichomonas musculis could drive the host's glucose...

Objective: To analyze the infection specie-specificity of Plasmodium yoelii (P.y) BY265 strain and P. berghei (P.b) ANKA-luciferase strain in rats and mice. Methods: The sporozoites and merozoites of P.y and P.b were prepared. Infection was performed by injecting 1 × 10⁵P.y and P.b sporozoites to...

Giardia lamblia (Giardia) is among the most common intestinal pathogens in children in low- and middle-income countries (LMICs). Although Giardia associates with early-life linear growth restriction, mechanistic explanations for Giardia-associated growth impairments remain elusive. Unlike other...

Background: Invasion of red blood cells by Plasmodium falciparum merozoites is governed by multiple receptor-ligand interactions which are critical for bridging the two cells together. The critical function of these ligands for invasion and their direct exposure to the host immune system makes them ...

Cryptosporidiosis is a waterborne protozoal infection that may cause life-threatening diarrhea in undernourished children living in unsanitary environments. The aim of this study is to identify new biomarkers that may be related to gut-brain axis dysfunction in children suffering from the...

Background: Toxoplasmosis is a protozoan disease caused by Toxoplasma gondii that can cause fetal abortion, stillbirth, death, or fetal and neonatal abnormalities. Spiramycin prophylactic purpose is to prevent fetal infection in toxoplasmosis. While Moringa oleifera contains bioactive compounds...

As important immunomodulators, CpG ODNs have broad application prospects in the treatment and prevention of leishmaniasis. In order to explore the immunomodulatory effect of CpG ODNs on mice infected with Leishmania parasites in different nutritional status, TLR9 agonist CpG ODN 2395 or TLR9...