Nonalcoholic fatty liver disease is the hepatic sign of metabolic syndrome. Here, we aimed to assess the effects of garlic and its major components on fasting plasma glucose, fasting insulin, and lipid profile levels in animal models of nonalcoholic fatty liver disease. A systematic search in...

S-allylmercaptocysteine (SAMC) is one of the characteristic sulfur constituents in aged garlic extract and has been shown to exert various pharmacological actions. However, because of the short half-life of SAMC, its metabolic profile and mode of action remain largely unclear. We investigated the...

A high-fat-enriched diet causes an increase in the level of oxidized LDL (Ox-LDL) in the blood. The presence of Ox-LDL will activate macrophages to secrete pro-inflammatory cytokines and lead to severe inflammation. Single bulb garlic has a potential anti-inflammatory effect due to of high-fat...

Garlic (Allium sativum) is a potentially beneficial functional food that is extensively grown around the globe. We have investigated the effect of roasted garlic on a dextran sodium sulfate (DSS)-induced intestinal permeability model in mice. Mice were divided into four diet groups: CON, DSS, RG...

This study investigated the potential of garlic polysaccharides (GPs) from garlic pomace as iron carriers. The obtained GP-Fe (III) complexes had a higher molecular weight (5646 Da) and more fructose (90.46%) than the GPs did and contained 9.7% Fe (III). GPs were mainly composed of (→ 2)-β-d-Fruf...

This study aimed to screen novel angiotensin I-converting enzyme (ACE) inhibitory peptides from garlic proteins and to explore their underlying antihypertensive mechanisms in vivo. After simulated hydrolysis and in silico screening, two novel peptides (MGR and HDCF) were obtained with the highest...

Background: Black garlic, also known as fermented garlic, is a useful food that may have therapeutic benefits. The aim of this study was to analyze the impact of fermented garlic and orlistat therapy on obese rats. Methods: A total of 40 male albino rats (245-250 g) were fed either an HFD (n = 32)...

This study intends to explore the antihyperglycemic effect and the possible hypoglycemic mechanism of garlic (Allium sativum L.) polysaccharide (GP) using an animal model. Kunming mice were fed with GP (1.25, 2.5, 5.0 g/kg.bw) for five weeks after insulin resistance (IR) engendering by a...

We developed low temperature-aged garlic (LTAG) to remove its unique and spicy flavor and evaluated the anti-fatigue properties of LTAG against exercise-induced fatigue in mice. In the results, the treadmill running time to exhaustion in the mice fed LTAG was prolonged compared with the control....

The present work is aimed at exploring dynamic homoeopathic potencies of Allium sativum 30CH and 200CH in hyperlipidemia on High Fat Diet induced experimental Male albino wistar rats. High Fat diet (HFD) has been fed to albino wistar rats to induce cholesterol. The period of experiment is 60 days,...