Neurogenesis in Alzheimer's disease (AD) is impaired, and thus promoting neurogenesis is a promising strategy for treating AD-related cognition impairment. Here, we found that 20S-protopanaxatriol (PPT) can alleviate cognitive deficits in an AlCl₃-induced AD zebrafish model in Y and T maze tests...

Purpose: Voriconazole (VOR) is combined with atorvastatin (ATO) to treat fungal infections in patients with dyslipidemia in clinical practice. However, the pharmacokinetic interactions and potential mechanisms between them are unknown. Therefore, this study aimed to investigate the pharmacokinetic...

Our previous study revealed that Trp-Cys-Pro-Phe-Ser-Arg-Ser-Phe (WCPFSRSF) exerted memory-improving ability in sleep-deprived mice; however, the underlying regulatory network was still unclear. The purpose of this study was to evaluate the effects of WCPFSRSF in sleep-deprived mice and to clarify...

Our previous study has indicated that Somatostatin type-2 receptor (SSTR2) antibody enhances mechanical hyperalgesia in dorsal root ganglion neurons (DRGs) based on Pinch-nerve injury painful model. However, more details on the role of SSTR2 involved should have been clearly elucidated. Here in...

Bifidobacterium animalis subsp. Lactis IU-100(IU-100) is a strain with good safety and tolerance. In this study, the effects of IU-100on relieving constipation in mice and human were evaluated. The mice were randomly divided into 6 groups and the constipation model was established by intragastric...

High-throughput lipidomics technology was used to explore the potential therapeutic targets and mechanism of action of gelanxinning capsule on rat model with coronary heart disease (CHD). This study attempts to provide a novel method to interpret the molecular mechanism of traditional medicine. The ...

The pervasive use of neonicotinoid insecticides (neonics) has led to increasing concerns regarding the potential health risks associated with them. Breast milk is the main food source of infants, and thus, the presence of chemicals in breast milk has a greater impact on infant health. However,...

Sodium metabisulphite (SMB) is the most used foods and drugs antioxidant among sulfites . So far, there were few studies about its harm, especially in mast cells. Our study was to investigate the effects of SMB on mitophagy and pyroptosis in mast cells. The results revealed that SMB...

The aim of this study was to investigate the effects and mechanisms of polyunsaturated fatty acids (PUFAs) and lipoxin A4 (LXA4) on preeclampsia (PE). The LXA4 level was significantly reduced in PE rats. The PUFA diet upregulated the expressions of lipoxygenase 12 (LOX12) and lipoxygenase 15...

Phloretin loaded porous starch (Ph-PS) were prepared for its application in food. The effects of Ph-PS in vitro release and its ability against AAPH-induced oxidative stress in vivo zebrafish model were investigated. Ph-PS was prepared by absorption method, the physical and chemical...