Objective: We investigated the toxicological mechanism by which perfluorooctane sulfonate (PFOS) induces liver injury via ferroptosis. Methods: Primary mouse hepatocytes were treated with LD50 = 55 M PFOS. Their cytotoxicity was detected by CCK-8 and LDH assays, while JC-1 staining was used to...

Berberine (BBR), which is a compound derived from the Chinese medicinal plant Coptis chinensis, promotes weight loss, but the molecular mechanisms are not well understood. Here, we show that BBR increases the serum level of growth differentiation factor 15 (GDF15), which is a stress response...

In order to enhance the loading of naringin (NA) in OSA modified porous starch (OSAPS) by optimization experiments and further enhance the in vivo bioavailability of NA with the form of complex, OSAPS-NA complexes were prepared by antisolvent precipitation method and metabolic kinetic studies were...

Chronic kidney disease (CKD) is becoming a major public health problem worldwide. This study aimed to explore whether peanut skin extract (PSE) has protective effects against high-fat and high-fructose (HF) diet-induced kidney injury. Rats were fed HF diet in the whole experiment, while rats in...

This study explored the effects of sesamin on nonalcoholic steatohepatitis (NASH). High-fat and high-fructose diet-fed mice supplemented with or without sesamin. The results suggested that sesamin-treated mice lost body weight and fat tissue weight, had lower levels of serum metabolic parameters,...

A sensitive and rapid ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was hereby developed for the determination of seven components, namely, glycyrrhizic acid, glycyrrhetinic acid, dehydrotumulosic acid, isoliquiritin, liquiritin, atractylenolide III, and...

Ellagic acid (EA) is an abundant dietary polyphenol with multifarious health benefits but low bioavailability. To increase its bio-efficacy, converting EA to urolithins by supplementing urolithin-producing bacteria, e.g., Gordonibacter urolithinfaciens (G.uro), could be a solution. This work first...

Platelet chemokines play well-established roles in the atherosclerotic inflammation. Cyanidin-3-O-β-glucoside (Cy-3-g) is one of the main bioactive compounds in anthocyanins, but its effects on chemokines during atherosclerosis have not been determined yet. In the present study, ApoE-/- mice were...

The interaction of nanocarriers with gastrointestinal enzymes upon oral administration significantly impacts their performance as delivery systems. This work investigated the interaction between epigallocatechin gallate (EGCG) loaded into banana resistant starch nanoparticles (RSNPs) and digestive...

In this study, we investigated the effects of Ganoderma lucidum aqueous extract (GLW) on improving learning and memory impairment (LMI) and analyzed the key genes and pathways involved. GLW can improve LMI in mice by increasing the activities of SOD and GSH-Px, increasing the contents of GLU and...