To explore the relationship between the dose of compound probiotics and intestinal microflora, growth performance, metabolism of experimental animal, 6-week-old BALB/C mice were intragastric administration with 10⁸(low dose), 10⁹(medium dose) and 10¹⁰ CFU/mL(high dose) compound probiotics every day ...

Background: The renin-angiotensin system (RAS) is activated in inflammatory bowel disease (IBD), and vitamin D deficiency aggravates the development of colitis, but the relationship between the local colonic RAS and vitamin D is unclear with regard to the pathogenesis of IBD. Aims: To investigate...

Acrylamide (ACR) is a water-soluble chemical that is commonly used in chemical and cosmetic manufacture. Many studies have been carried out to investigate the neurotoxicity mechanisms of ACR, resulting in oxidative stress and nerve damages. One of the commonly used traditional Chinese medicines is...

Objective: High-fat diet has adverse effects on cardiovascular health, but the mechanism remains unclear. This study aims to investigate the effect of stearic acid induced by high-fat diet on the function of L-type calcium channel in vascular smooth muscle cells (VSMCs). Methods: Four week-old SD...

The interconnection between obesity and central nervous system (CNS) neurological dysfunction has been widely appreciated. Accumulating evidence demonstrates that obesity is a risk factor for CNS neuroinflammation and cognitive impairment. However, the extent to which CNS disruption influences...

Background: Vitamin D receptor (VDR) and SLC26A3 (DRA) have been identified as pivotal protective factors in maintaining gut homeostasis in IBD patients. However, the specific mechanism underlying the increased intestinal susceptibility to inflammation induced by the loss of VDR and whether DRA...

Resveratrol is a dietary polyphenol that interacts with gut microbiota to possess various biological activities. To identify the microbial metabolites of resveratrol, fresh feces from 12 volunteers were cultured in vitro. Their urine samples were collected after taking a commercial capsule...

High levels of Aβ accumulation leads to hippocampal damage, resulting in impaired oxidative stress responses and synaptic function, and ultimately cognitive impairment. Here, we investigated the effects of olfactory stimuli on Aβ1-42-induced AD models using an essential oil containing drug-food...

It is important to maintain the normal function of the pancreas in the prevention and intervention of type 2 diabetes mellitus (T2DM). This study was undertaken to explore the protective effects of fucoidan on the pancreas in T2DM rats induced by using a high fat diet (HFD) and low dose of...

Capsaicin (Cap) is a promising bioactive compound having many health-promoting benefits. However, it is difficult to be applied in food due to its poor aqueous solubility, low stability and bioavailability. Besides, its strong spicy taste and irritation to the gastrointestinal tract further limit...