Skeletal muscle dysfunction caused by obesity is characterized by the decline in mitochondrial content and function. 5-Heptadecylresorcinol (AR-C17) is a specific bioactive component derived from whole wheat and rye, which has been evidenced to improve obesity-associated skeletal muscle...

Currently, there have been breakthroughs in the study of the underlying mechanisms of pulmonary arterial hypertension, but treatment is still challenging. The aim of this study was explore the effect of kaempferol in PAH and discover the mechanism of this process. First, we assessed the effect of...

According to data from the World Health Organization, there were about 3 million deaths caused by alcohol consumption worldwide in 2016, of which about 50% were related to liver disease. Alcohol consumption interfering with the normal function of adipocytes has an important impact on the...

5-Heptadecylresorcinol (AR-C17), a well-known biomarker for whole grain rye consumption, is a primary homolog of alkylresorcinols. In this study, the effects of AR-C17 on the thermogenesis of brown adipocytes and 3T3-L1 adipocytes were investigated. The results showed that AR-C17 increased sirtuin...

Sea cucumber is a traditional Chinese tonic with various bioactivities. This study systematically investigated the immunomodulatory effect of saponins extracted from sea cucumber residues (SCRSS) at doses of 2.5, 5.0 and 10.0 mg/(kg mb.d) on immunosuppressive mice. The results showed that SCRSS at...

Epigallocatechin 3-gallate (EGCG), an abundant polyphenolic component derived from green tea extract, possesses versatile bioactivities that can combat many diseases. During the last decade, EGCG was shown to be effective in experimental models of Parkinson's disease (PD). Several experimental...

Objective: To explore the therapeutic effect and mechanism of G-Rh2 on metabolic syndrome (MS) in high-fat diet (HFD) induced obese mice. Methods: The therapeutic effect of G-Rh2 on MS mice was evaluated by body weight, insulin sensitivity, blood lipid level and liver function. The changes of lipid ...

Previous studies indicated an intrinsic relationship between infant diet, intestinal microbiota composition and fermentation activity with a strong focus on the role of breastfeeding on microbiota composition. Yet, microbially formed short-chain fatty acids acetate, propionate and butyrate and...

Scope: In the present study, effect of pterostilbene on β-amyloid 1-42 (Aβ_1-42) induced cognitive impairment in mice is investigated and explored its possible mechanism of action. Methods and results: The behavior results show that pterostilbene alleviated Aβ_1-42-induces cognitive dysfunction...

Daidzein and puerarin are natural polyphenols with multiple bioactivities, but their bioavailability is low. In this study, whey protein was chosen as the matrix and daidzein or puerarin was chosen as a ligand to prepare complexes. The interaction between daidzein/puerarin and whey protein was...