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Study adds to growing evidence of the dangers of high fructose consumption

Date
24 February 2021
Abstract

Background: Fructose consumption has been linked to nonalcoholic fatty liver disease (NAFLD) in children. However, the effect of high-fructose corn syrup (HFCS) compared with sucrose in pediatric NAFLD has not been investigated. Objectives: We tested whether the isocaloric substitution of dietary...

Author(s)
Maj, M.; Harbottle, B.; Thomas, P. A.; Hernandez, G. V.; Smith, V. A.; Edwards, M. S.; Fanter, R. K.; Glanz, H. S.; Immoos, C.; Burrin, D. G.; Santiago-Rodriguez, T. M.; Frano, M. R. la; Manjarín, R.
Publisher
Oxford University Press, Cary, USA
Citation
Journal of Nutrition, 2021, 151, 5, pp 1139-1149
Abstract

Background: Insulin resistance (IR) is a pathophysiological construct that derives a series of metabolic disturbances that promote cardiometabolic dysfunction. This study evaluated mediating and modifying effects of homeostatic model assessment-based IR (HOMA-IR) on the association between...

Author(s)
Wu PeiWen; Tsai, S.; Lee ChunYing; Lin WeiTing; Chin YuTing; Huang HsiaoLing; Seal, D. W.; Chen, T.; Lee ChienHung
Publisher
Nature Publishing Group, London, UK
Citation
International Journal of Obesity, 2021, 45, 4, pp 828-839
Abstract

The rapid increase in obesity, diabetes and fatty liver disease in children over the past 20 years has been linked to increased consumption of high fructose corn syrup (HFCS), making it essential to determine the short- and long-term effects of HFCS during this vulnerable developmental window. We...

Author(s)
Bhat, S. F.; Pinney, S. E.; Kennedy, K. M.; McCourt, C. R.; Mundy, M. A.; Surette, M. G.; Sloboda, D. M.; Simmons, R. A.
Publisher
Wiley, Oxford, UK
Citation
Journal of Physiology, 2021, 599, 5, pp 1487-1511
Abstract

Increased risk of pancreatic cancer may be associated with consumption of sugar containing foods. The aim of this study was to evaluate the effect of peach nectar containing high fructose corn sirup (HFCS) consumption in a pancreatic carcinogenesis rat model induced by 7,12-Dimethyl benzanthracene...

Author(s)
Ozcan-Sinir, G.; Inan, S.; Suna, S.; Tamer, C. E.; Akgül, M. B.; Bagdas, D.; Sonmez, G.; Evrensel, T.; Kaya, E.; Sarandol, E.; Dündar, H. Z.; Tarim, O. F.; Ercan, I.; Sıgırlı, D.; Incedayi, B.; Copur, O. U.
Publisher
Routledge, Philadelphia, USA
Citation
Nutrition and Cancer, 2021, 73, 2, pp 339-349
Abstract

Sugar-sweetened beverage (sugar-SB) consumption is associated with body weight gain. We investigated whether the changes of (D) circulating leptin contribute to weight gain and ad libitum food intake in young adults consuming sugar-SB for two weeks. In a parallel, double-blinded, intervention...

Author(s)
Sigala, D. M.; Widaman, A. M.; Hieronimus, B.; Nunez, M. V.; Havel, P. J.; Lee Vivien; Benyam, Y.; Bremer, A. A.; Medici, V.; Stanhope, K. L.; Keim, N. L.
Publisher
MDPI AG, Basel, Switzerland
Citation
Nutrients, 2020, 12, 12,
Abstract

High consumption of fructose and high-fructose corn syrup is related to the development of obesity-associated metabolic diseases, which have become the most relevant diet-induced diseases. However, the influences of a high-fructose diet on gut microbiota are still largely unknown. We therefore...

Author(s)
Beisner, J.; Gonzalez-Granda, A.; Basrai, M.; Damms-Machado, A.; Bischof, S. C.
Publisher
MDPI AG, Basel, Switzerland
Citation
Nutrients, 2020, 12, 11,
Abstract

Objective: Obesity is associated with myocardial fibrosis and impaired diastolic relaxation, abnormalities that are especially prevalent in women. Normal coronary vascular endothelial function is integral in mediating diastolic relaxation, and recent work suggests increased activation of the...

Author(s)
Sowers, J. R.; Habibi, J.; Jia GuangHong; Bostick, B.; Manrique-Acevedo, C.; Lastra, G.; Yang Yan; Chen DongQing; Sun Zhe; Domeier, T. L.; Durante, W.; Whaley-Connell, A. T.; Hill, M. A.; Jaisser, F.; Demarco, V. G.; Aroor, A. R.
Publisher
Elsevier Inc, New York, USA
Citation
Metabolism, Clinical and Experimental, 2020, 109,
AbstractFull Text

Introduction: Non-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis to nonalcoholic steatohepatitis (NASH) and liver fibrosis. Recently, consumption of high fructose corn syrup (HFCS) has been associated with NAFLD development. Objective: The aim of this study was to investigate...

Author(s)
Armiliato, G. N. de A.; Nardelli, M. J.; Ferolla, S. M.; Lima, É. C.; Lisboa, Q. C.; Vidigal, P. V. T.; Ferrari, T. C. de A.; Couto, C. A.
Publisher
Sociedad Española de Dietética y Ciencias de la Alimentación (S.E.D.C.A.), Madrid, Spain
Citation
Nutrición Clínica y Dietética Hospitalaria, 2020, 40, 2, pp 17-24
Abstract

Context: Free, or added, sugars are considered important determinants in the pandemics of obesity and associated chronic diseases, and fructose has emerged as the sugar of main concern. Objective: The aim of this review was to assess the evidence of the effects of isoenergetic replacement of...

Author(s)
Fattore, E.; Botta, F.; Bosetti, C.
Publisher
Oxford University Press, Cary, USA
Citation
Nutrition Reviews, 2020, 79, 2, pp 209-226

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