The rising prevalence of obesity and diabetes is a significant health concern both in globally and is now regarded as a worldwide epidemic. Added sugars like sucrose and high-fructose corn syrup (HFCS) are a major concern due to their link with an increased incidence of diet-induced obesity and...
Publisher
Korean Society of Clinical Nutrition, Seoul, Korea Republic
Citation
Clinical Nutrition Research, 2023, 12, 3, pp 229-243
The metabolic effects of sugars and fat lie at the heart of the "carbohydrate vs fat" debate on the global obesity epidemic. Here, we use nutritional geometry to systematically investigate the interaction between dietary fat and the major monosaccharides, fructose and glucose, and their impact on...
Author(s)
Wali, J. A.; Ni Duan; Facey, H. J. W.; Dodgson, T.; Pulpitel, T. J.; Senior, A. M.; Raubenheimer, D.; Macia, L.; Simpson, S. J.
Publisher
Nature Publishing Group, London, UK
Citation
Nature Communications, 2023, 14, 7,
Consumption of high-fructose corn syrup (HFCS) in the diet is a causal factor in the development of abdominal obesity; however, the molecular mechanism behind this association is still up for debate. This study evaluated the metabolic disturbances that are caused by HFCS on adipose tissue as well...
Author(s)
Aslan, E.; Sadi, G.; Guzel, H.; Karaca, C.; Korkmaz, O. A.; Pektas, M. K.; Celegen, M.; Aladag, T.; Oncu, S.; Pektas, M. B.
Publisher
Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland
Citation
Polish Journal of Food and Nutrition Sciences, 2023, 73, 2, pp 120-129
Metformin, a frontline therapy for type 2 diabetes and related metabolic diseases, results in variable outcomes. This study aimed to investigate whether sweetened beverages (caloric or non-caloric) affect the therapeutic benefits of metformin on glucose, food intake, and weight loss in diet-induced ...
Author(s)
Arashdeep Singh; Rourk, K.; Bernier, A.; Lartigue, G. de
Publisher
MDPI AG, Basel, Switzerland
Citation
Nutrients, 2023, 15, 11,
The presence of obesity and metabolic syndrome is strongly linked with chronic kidney disease (CKD), but the mechanisms responsible for the association are poorly understood. Here, we tested the hypothesis that mice with obesity and metabolic syndrome might have increased susceptibility to CKD from ...
Author(s)
Andres-Hernando, A.; Orlicky, D. J.; Cicerchi, C.; Kuwabara, M.; Garcia, G. E.; Nakagawa, T.; Sanchez-Lozada, L. G.; Johnson, R. J.; Lanaspa, M. A.
Publisher
MDPI AG, Basel, Switzerland
Citation
Biomolecules, 2023, 13, 5,
An unhealthy lifestyle is associated with metabolic disorders and neuroinflammation. In this study, the efficacy of m-trifluoromethyl-diphenyl diselenide [(m-CF3-PhSe)2] against lifestyle model-related metabolic disturbances and hypothalamic inflammation in young mice was investigated. From...
Author(s)
Müller, S. G.; Jardim, N. S.; Zeni, G.; Nogueira, C. W.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Food and Chemical Toxicology, 2023, 176,
Background: High-fructose corn syrup-55 (HFCS-55) is a common sweetener in the food industry. Recently, we have investigated and published the effects of uncontrolled long-term oral ingestion of 55-HFCS compared to sucrose on primary ovarian insufficiency in female rats. This study aimed to compare ...
Author(s)
Mirzaei, R.; Bidgoli, S. A.; Khosrokhavar, R.; Shoeibi, S.; Ashtiani, H. A.
Publisher
Islamic Azad University, Tehran Medical Unit, Tehran, Iran
Citation
Medical Sciences Journal of Islamic Azad University, 2023, 33, 1, pp fa29-fa39
High-fructose corn syrup (HFCS) is consumed worldwide. However, it has been demonstrated that an increased intake of sweetened beverages, including those sweetened using fructose, is associated with the development of childhood obesity. It is unknown why the negative effects of fructose are...
Author(s)
Mizuno, G.; Yamada, H.; Munetsuna, E.; Ando, Y.; Teshigawara, A.; Ito, M.; Kageyama, I.; Nouchi, Y.; Wakasugi, T.; Sakakibara, T.; Yamazaki, M.; Ishikawa, H.; Suzuki, K.; Hashimoto, S.; Ohashi, K.
Publisher
Elsevier, New York, USA
Citation
Nutrition Research, 2023, 110, pp 57-65
This review will examine the role of 5'-adenosine monophosphate-activated protein kinase (AMPK) in the treatment of obesity, medical nutrition and chronic diseases, and its relationship with nutrition. In the literature, the number of studies examining the direct relationship of AMPK with nutrition ...
Author(s)
Canbolat, E.; Cakıroglu, F. P.
Publisher
Taylor & Francis, Philadelphia, USA
Citation
Critical Reviews in Food Science and Nutrition, 2023, 63, 4, pp 449-456
The consumption of fructose as sugar and high-fructose corn syrup has markedly increased during the past several decades. This trend coincides with the exponential rise of metabolic diseases, including obesity, nonalcoholic fatty liver disease, cardiovascular disease, and diabetes. While the...
Author(s)
Jung SunHee; Bae HoSung; Song WonSuk; Jang CholSoon
Publisher
Annual Reviews, Palo Alto, USA
Citation
Annual Review of Nutrition, 2022, 42, pp 45-66