Mycoplasma capricolum subsp. capripneumoniae

Pictures

Picture	Title	Caption	Copyright
Title CCPP Diagnostic Media Caption Mycoplasma capricolum subsp. capripneumoniae strain F38 colonies after 7 days of incubation on CCPP Diagnostic Media (Mycoplasma Experience, Reigate, UK) showing dark pigmentation and red crystalline deposits. Copyright ©Mycoplasma Experience/Reigate, UK	CCPP Diagnostic Media	Mycoplasma capricolum subsp. capripneumoniae strain F38 colonies after 7 days of incubation on CCPP Diagnostic Media (Mycoplasma Experience, Reigate, UK) showing dark pigmentation and red crystalline deposits.	©Mycoplasma Experience/Reigate, UK

Identity

Preferred Scientific Name

• Mycoplasma capricolum subsp. capripneumoniae

Other Scientific Names

• Mycoplasma F38
• Mycoplasma strain F38

English acronym

• MCCP

Taxonomic Tree

• Domain: Bacteria
•     Phylum: Firmicutes
•         Class: Mollicutes
•             Order: Mycoplasmatales
•                 Family: Mycoplasmataceae
•                     Genus: Mycoplasma
•                         Species: Mycoplasma capricolum subsp. capripneumoniae

Diseases Table

Distribution Table

The distribution in this summary table is based on all the information available. When several references are cited, they may give conflicting information on the status. Further details may be available for individual references in the Distribution Table Details section which can be selected by going to Generate Report.

Pathogen Characteristics

M. capricolum subsp. capripneumoniae is a member of the Mycoplasma mycoides cluster which are a phylogenetically related grouping of ruminant mycoplasmas and include M.capricolum subsp. capricolum, M. mycoides subsp. mycoides SC, M. mycoides subsp. mycoides LC, M. mycoides subsp. capri, and Bg7. The phenotypic and genetic traits shared in this group have their basis in conventional biochemical and immunological tests such as colony size and growth characteristics, substrate utilization, isozyme patterns, protein profiles and DNA hybridization studies (Rodwell, 1982; Salih and Rosenbusch, 1983; Cottew et al., 1987). A close relationship between M. capricolum subsp. capripneumoniae and M. capricolum subsp. capricolum was found by DNA probes and sequence comparison of members of the M. mycoides cluster but a probe capable of distinguishing between them was developed indicating that they were differences between the species (Taylor et al., 1992). Comparisons of sequences of a putative membrane protein from these strains also showed a close relationship between M. capricolum subsp. capripneumoniae and M.capricolum subsp. capricolum which together with Bg7 formed a subcluster distinct from the M. mycoides subspecies (Thiaucourt et al., 2000).

Phylogenetic groupings have been made by close examination of the sequences from both operons of 16S rRNA from many mycoplasmas and confirm the position of M. capricolum subsp. capripneumoniae within the M. mycoides cluster which is in the spiroplasma group (Weisburg et al., 1989; Bascuñana et al., 1994; Pettersson et al., 1996a; Pettersson et al., 1996b; Pettersson et al., 1998). Intraspecific variations in these genes from M. capricolum subsp. capripneumoniae strains from diverse geographic areas have shown the existence of two evolutionary lines, and this has also been the finding from molecular typing by the AFLP (amplified fragment length polymorphism) method (Kokotovic et al., 2000). Analyses of the 16sRNA genes from a narrower ranging group of strains have also shown sequence differences, and collectively, the number of differences between these strains was found to be greater that the number of differences used to distinguish between species of mycoplasmas. Nevertheless, 16S rRNA gene sequence analysis may be a useful epidemiological tool for M. capricolum subsp. capripneumoniae (Heldtander et al., 2001).

The polysaccharide capsule of M. capricolum subsp. capripneumoniae may have a similar role to that described for M. mycoides subsp. mycoides SC in contagious bovine pleuropneumonia (CBPP) (Rurangirwa et al., 1987). The galactan capsules are generally considered to promote pathogenicity either directly by toxic effects, or by promoting resistance to phagocytosis (Rosenbusch and Minion, 1992).

There is very little information on the pathogenic mechanisms of M. capricolum subsp. capripneumoniae, although some hypothesis can be drawn from comparison with other mycoplasmoses and especially with CBPP (Thiaucourt and Bölske, 1996). A striking feature of CCPP is the host and tissue specificity of the causative agent, as lesions are produced only in goat lungs. Some mycoplasmas have adhesins, but no such component has yet been described for M. capricolum subsp. capripneumoniae. Although M. capricolum subsp. capripneumoniae is present in high quantities in affected lungs, there is no dissemination to other organs. This may be due to a specific reaction of the lung tissue towards a mycoplasmal component that leads to an exacerbated inflammatory response (Thiaucourt and Bölske, 1996).

Disease(s) associated with this pathogen is/are on the list of diseases notifiable to the World Organisation for Animal Health (OIE). The distribution section contains data from OIE's Handistatus database on disease occurrence. Please see the AHPC library for further information from OIE, including the International Animal Health Code and the Manual of Standards for Diagnostic Tests and Vaccines. Also see the website: www.oie.int.

Host Animals

References

Bascunana CR; Mattsson JG; Bölske G; Johansson KE, 1994. Characterization of the 16S rRNA genes from Mycoplasma sp. strain F38 and development of an identification system based on PCR. Journal of Bacteriology, 176(9):2577-2586; 58 ref.

Cottew GS; Brerard A, DaMassa AJ et al. , 1987. Taxonomy of the Mycoplasma mycoides cluster. Israel Journal of Medical Sciences, 23:632-635.

Heldtander M; Wesonga H, Bölske G et al. , 2001. Genetic diversity and evolution of Mycoplasma capricolum subsp. capripneumoniae strains from eastern Africa assessed by 16S rDNA sequence analysis. Veterinary Microbiology, 78:13-28.

Kokotovic B; Bölske G; Ahrens P; Johansson K-E, 2000. Genomic variations of Mycoplasma capricolum subsp. capripneumoniae detected by amplified fragment length polymorphism (AFLP) analysis. FEMS Microbiology Letters, 184:63-68.

OIE Handistatus, 2002. World Animal Health Publication and Handistatus II (dataset for 2001). Paris, France: Office International des Epizooties.

OIE Handistatus, 2003. World Animal Health Publication and Handistatus II (dataset for 2002). Paris, France: Office International des Epizooties.

OIE Handistatus, 2004. World Animal Health Publication and Handistatus II (data set for 2003). Paris, France: Office International des Epizooties.

OIE Handistatus, 2005. World Animal Health Publication and Handistatus II (data set for 2004). Paris, France: Office International des Epizooties.

Pettersson B; Bölske G; Thiaucourt F; Uhlén M; Johansson KE, 1998. Molecular evolution of Mycoplasma capricolum subsp. capripneumoniae strains, based on polymorphisms in the 16S rRNA genes. Journal of Bacteriology, 180(9):2350-2358; 2 ref.

Pettersson B; Leitner T; Ronaghi M; Bölske G; Uhlén M; Johansson KE, 1996. Phylogeny of the Mycoplasma mycoides cluster as determined by sequence analysis of the 16S rRNA genes from the two rRNA operons. Journal of Bacteriology, 178(14):4131-4142; 59 ref.

Pettersson B; Uhlén M; Johansson KE, 1996. Phylogeny of some mycoplasmas from ruminants based on 16S rRNA sequences and definition of a new cluster within the hominis Group. International Journal of Systematic Bacteriology, 46(4):1093-1098; 24 ref.

Rodwell AW, 1982. The protein fingerprints of mycoplasmas. Review of Infectious Diseases, Supplement 4:8-17.

Rosenbusch RF; Minion FC, 1992. Cell envelope:Morphology and Biochemistry. In: Maniloff J, McElhaney RN, Finch LR Baseman JB, eds. Molecular Biology and Pathogenesis. Washington DC, USA: American Society for Microbiology, 73-77.

Rurangirwa FR; McGuire TC; Magnuson NS; Kibor A; Chema S, 1987. Composition of a polysaccharide from mycoplasma (F-38) recognised by antibodies from goats with contagious pleuropneumonia. Research in Veterinary Science, 42(2):175-178; 16 ref.

Salih BA; Rosenbusch RF, 1983. Antibody response to Mycoplasma bovoculi of naturally and experimentally infected calves. [Abstract]. Abstracts of Papers presented at the Annual Meeting of the Conference of Research Workers in Animal Disease, Chicago, November 1983, 64:4.

Taylor TK; Bashiruddin JB; Gould AR, 1992. Relationships between members of the Mycoplasma mycoides cluster as shown by DNA probes and sequence analysis. International Journal of Systematic Bacteriology, 42(4):593-601; 19 ref.

Thiaucourt F; Bölske G, 1996. Contagious caprine pleuropneumonia and other pulmonary mycoplasmoses of sheep and goats. Revue Scientifique et Technique - Office International des épizooties, 15(4):1397-1414; 69 ref.

Thiaucourt F; Lorenzon S; David A; Breard A, 2000. Phylogeny of the Mycoplasma mycoides cluster as shown by sequencing of a putative membrane protein gene. Veterinary Microbiology, 72(3/4):251-268; 44 ref.

Weisburg WG; Tully JG; Rose DL; Petzel JP; Oyaizu H; Yang D; Mandelco L; Sechrest J; Lawrence TG; Etten Jvan; Maniloff J; Woese CR, 1989. A phylogenetic analysis of the mycoplasmas: basis for their classification. Journal of Bacteriology, 171(12):6455-6467; 50 ref.

Distribution References

OIE Handistatus, 2005. World Animal Health Publication and Handistatus II (dataset for 2004)., Paris, France: Office International des Epizooties.

Distribution Maps