Nairobi sheep disease virus

Pictures

Identity

Preferred Scientific Name

• Nairobi sheep disease virus

Taxonomic Tree

• Domain: Virus
•     Unknown: "Positive sense ssRNA viruses"
•         Unknown: "RNA viruses"
•             Order: Mononegavirales
•                 Family: Bunyaviridae
•                     Genus: Nairovirus
•                         Species: Nairobi sheep disease virus

Diseases Table

Distribution Table

The distribution in this summary table is based on all the information available. When several references are cited, they may give conflicting information on the status. Further details may be available for individual references in the Distribution Table Details section which can be selected by going to Generate Report.

Pathogen Characteristics

NSD virus is a member of the Nairovirus genus of the family Bunyaviridae. The nucleus contains three segments of single-stranded RNA and is thermolabile. At 4°C it has a half life of 3-4 days, and of 100 minutes at 37°C. The virus is sensitive to acid pH (3), ether and to sodium descoxycholate (Terpstra, 1969). Virus replication occurs in the cytoplasm and by budding from the membranes of smooth surface intracellular vesicles associated with the Golgi complex. Virus particles are released by exocytosis and by cell lysis. The molecular basis for this is the retention of viral envelope glycoproteins G1 and G2 in the Golgi complex during replication. Virus particles are spherical in shape and approximately 80-100 nm in diameter, with denser core and a double envelope of 5-nm thickness. They are typical of the Bunyavirus particles.

Disease(s) associated with this pathogen is/are on the list of diseases notifiable to the World Organisation for Animal Health (OIE). The distribution section contains data from OIE's Handistatus database on disease occurrence. Please see the AHPC library for further information from OIE, including the International Animal Health Code and the Manual of Standards for Diagnostic Tests and Vaccines. Also see the website: www.oie.int.

Host Animals

Vectors and Intermediate Hosts

References

OIE Handistatus, 2002. World Animal Health Publication and Handistatus II (dataset for 2001). Paris, France: Office International des Epizooties.

OIE Handistatus, 2003. World Animal Health Publication and Handistatus II (dataset for 2002). Paris, France: Office International des Epizooties.

OIE Handistatus, 2004. World Animal Health Publication and Handistatus II (data set for 2003). Paris, France: Office International des Epizooties.

OIE Handistatus, 2005. World Animal Health Publication and Handistatus II (data set for 2004). Paris, France: Office International des Epizooties.

Terpstra C, 1969. Nairobi sheep disease. Studies on virus properties, epizootiology and vaccination in Uganda. Thesis, University of Utrecht.

Distribution Maps