Myxobolus cerebralis (whirling disease agent)
- Summary of Invasiveness
- Taxonomic Tree
- Notes on Taxonomy and Nomenclature
- Diseases Table
- Distribution Table
- History of Introduction and Spread
- Risk of Introduction
- Pathogen Characteristics
- Host Animals
- Latitude/Altitude Ranges
- Notes on Natural Enemies
- Means of Movement and Dispersal
- Pathway Causes
- Pathway Vectors
- Economic Impact
- Environmental Impact
- Threatened Species
- Risk and Impact Factors
- Links to Websites
- Principal Source
- Distribution Maps
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PicturesTop of page
IdentityTop of page
Preferred Scientific Name
- Myxobolus cerebralis Hofer
Preferred Common Name
- whirling disease agent
Other Scientific Names
- Lentospora cerebralis Plehn
- Myxobolus chondrophagus Hofer
- Myxosoma cerebralis Kudo
- Triactinomyxon gyrosalmo Wolf and Markiw
Summary of InvasivenessTop of page
Myxobolus cerebralis, the myxozoan that causes whirling disease in salmon and trout, was first reported in Germany in the late 1890s. The resistance of European brown trout and the fact that whirling disease was not detected outside Europe for over 50 years suggest that it originated in that region. M. cerebralis has primarily been spread by transfers of subclinically infected fish but parasite establishment has been facilitated by the fact that its invertebrate host, Tubifex tubifex, occurs worldwide across a broad range of conditions. Impacts on aquaculture have been significant, but fundamental changes in trout culture and improvements in diagnostics have reduced impacts in hatcheries. Disease in wild populations, with significant impacts on these populations, is reported from the US Rocky Mountain region; the effectiveness of efforts to reduce impacts is difficult to assess. M. cerebralis is not regulated by the World Organisation for Animal Health; however, some countries require imports to be certified free of the parasite and most US states require inspection and certification.
Taxonomic TreeTop of page
- Domain: Eukaryota
- Kingdom: Metazoa
- Phylum: Cnidaria
- Subphylum: Myxozoa
- Class: Myxosporea
- Class: Myxobolus cerebralis
- Order: Bivalvulida
- Suborder: Platysporina
- Family: Myxobolidae
- Genus: Myxobolus
- Species: Myxobolus cerebralis
Notes on Taxonomy and NomenclatureTop of page
Myxozoan taxonomy is based primarily on the morphology and morphometrics of the myxospore stage and species descriptions follow the guidelines of Lom and Arthur (1989), although contemporary descriptions incorporate DNA sequence information (primarily the ssurRNA gene), which helps to distinguish between phenotypically similar species. Before the first life cycle was elucidated in 1984, actinospores and myxospores were assigned independent binomens in separate classes; the class Actinosporea was suppressed in 1994 by Kent et al. (1994). The current taxonomical scheme is outlined in Lom and Dyková (2006).
Myxobolus cerebralis Höfer 1903 is one of more than 2000 species of the phylum Myxozoa Grasse, 1970 (Lom and Dykova, 2006). It is a member of the predominant class Myxosporea Butschli, 1881 and the most speciose genus, Myxobolus Butschli, 1882 (syn. MyxosomaThelohan, 1892). The name is associated with its myxospore stage, known from fishes. The parasite has undergone several name changes over the decades after its discovery, but its binomen has reverted back to the original (Lom and Noble, 1984). Previous names include: Myxobolus chondrophagus Hofer, 1904; Lentospora cerebralis Plehn, 1905; and Myxosoma cerebralis Kudo, 1933. The actinospore stage in its life cycle was originally assigned an independent name, Triactinomyxon gyrosalmo (Wolf and Markiw, 1984), but has since been synonymised (Kent et al., 1994).
The phylum Myxozoa was initially considered part of the Protozoa but its affinities with Metazoa (multicellularity and phylogenetic position) have been recognised for several decades (Siddall et al., 1995), although its exact relationship has altered between the Bilateria and Cnidaria. The most recent study of new genomic sequences firmly places the Myxozoa within the phylum Cnidaria (Nesnidal et al., 2013); however no-one has proposed how to apply this knowledge taxonomically. The subphylum Myxozoa Grassé, 1970 is also currently unranked due to recent changes.
DistributionTop of page
M. cerebralis was first described in Europe and is now exotic on four other continents (Asia, Africa, North America and Oceania). The parasite is not an OIE listed pathogen, and there are few published reports of its current distribution in US States. Information has been compiled by the Whirling Disease Foundation, showing detailed occurrence in hatcheries and watersheds, and most of this data can be found on the Whirling Disease Initiative website (Whirling Disease Initiative, 2014). However, inconsistencies in survey methods and differences in the sensitivity of parasite detection methods have caused confusion about where the parasite occurs. Although there are many reports documenting detection of M. cerebralis, several points should be considered when interpreting this data.
- Detections based on disease signs (whirling behaviour) or characteristic spore morphology are unreliable because disease signs are not exclusive to M. cerebralis and because it is often difficult to distinguish between similar myxobolid spores. Confirmation by histological or molecular methods is essential. Thus some records should be considered unconfirmed or unreliable (eg. Japan, Mexico, South America, Canada).
- Detections of parasite DNA alone, although indicative of parasite presence, should be confirmed with further sampling to determine that parasite establishment has occurred. Establishment in some areas (e.g. Alaska hatcheries, some rivers in Oregon) appears transient.
- Many reports fail to distinguish between parasite introduction and establishment of the life cycle. Thus in many cases detection is based on shipments of infected fish received from Europe, but it is likely that the parasite never became established in the new region and there has been no subsequent work to confirm presence (e.g. South Africa, Lebanon and Morocco).
- Although M. cerebralis may have become established in fish culture facilities, hatchery practices have improved and many of these facilities are no longer positive or have been closed, yet remain on distribution lists.
- Surveys of natural fish populations are rare, so invasiveness and effects on natural populations are often unknown.
- Inclusion of some countries in distribution surveys resulted from misinterpretations of original reports (e.g. Korea, Venezuela) and should be considered invalid or unreliable records.
Distribution TableTop of page
The distribution in this summary table is based on all the information available. When several references are cited, they may give conflicting information on the status. Further details may be available for individual references in the Distribution Table Details section which can be selected by going to Generate Report.Last updated: 10 Jan 2020
|Continent/Country/Region||Distribution||Last Reported||Origin||First Reported||Invasive||Reference||Notes|
|Morocco||Absent, Intercepted only||Preudhomme (1970)|
|South Africa||Absent, Intercepted only||Wyk (1968)|
|Lebanon||Absent, Intercepted only||Halliday (1976)||Based on FAO report, 1972|
|Austria||Present||1972||Halliday (1976)||Based on FAO report, 1972|
|Belgium||Present||1972||Halliday (1976)||Based on FAO report, 1972|
|Bulgaria||Present||Kostova and Chikova (2011); Margaritov (1960)|
|Federal Republic of Yugoslavia||Present||Tomasec (1960)|
|Finland||Present||1932||Uspenskaya (1957)||Source cites report from 1932 of infections in natural salmon populations|
|Germany||Present, Widespread||Native||Hofer (1903)||First reported in non-native rainbow trout reared in earthen ponds|
|Hungary||Present||Halliday (1976)||Based on FAO report, 1972|
|Ireland||Present||Halliday (1976)||Based on FAO report, 1972|
|Liechtenstein||Present||Halliday (1976)||Based on FAO report, 1972|
|Luxembourg||Present||Halliday (1976)||Based on FAO report, 1972|
|Netherlands||Present||Halliday (1976)||Based on FAO report, 1972|
|Russia||Present||CABI (Undated a)||Present based on regional distribution.|
|-Central Russia||Present||Bogdanova (1968)|
|-Northern Russia||Present||Uspenskaya (1955)||Reports infections in natural salmon populations|
|-Russian Far East||Present||Bogdanova (1960)||Initial report of widespread enzootic focus of infection in the Sakhalin Islands, in cultured and natural populations. However, no subsequent evidence of infection or disease and status unclear|
|-Southern Russia||Present||Uspenskaya (1957)|
|Spain||Present||Cordero del Campillo et al. (1975)|
|United Kingdom||Present||Elson (1969); Hoffman (1990)|
|United States||Present||CABI (Undated a)||Present based on regional distribution.|
|-Alaska||Absent, Formerly present||2007||2006||Arsan et al. (2007); CABI (Undated)||M. cerebralis DNA detected at one rearing facility in fish with no clinical disease. Parasite DNA no longer detected in the 3 years after changes in hatchery management; hatchery subsequently closed.|
|-Arizona||Present||Introduced||2000||Bartholomew and Reno (2002); Steinbach et al. (2009)||Initial introduction of parasite in private ponds did not appear to result in establishment. Subsequent detection within the Glen Canyon National Recreation Area in 2007 and 2011|
|-California||Present, Widespread||Introduced||1966||Invasive||Yasutake and Wolf (1970)|
|-Colorado||Present, Widespread||Introduced||1987||Invasive||Barney et al. (1988); Walker and Nehring (1995)|
|-Connecticut||Present||1962||Introduced||1961||Hoffman et al. (1962)|
|-Idaho||Present, Widespread||Introduced||1987||Invasive||Hauck et al. (1988)|
|-Maryland||Present||2002||Introduced||1995||Bartholomew and Reno (2002)|
|-Massachusetts||Absent, Intercepted only||1966||1966||Hoffman (1990)|
|-Michigan||Present||Introduced||1968||Hnath (1970); Yoder (1972)|
|-Montana||Present, Widespread||Introduced||1994||Invasive||Vincent (1996)|
|-Nebraska||Present||Introduced||2001||Steinbach et al. (2009)|
|-Nevada||Present, Widespread||1970||Introduced||1957||Yasutake and Wolf (1970); Taylor et al. (1973)|
|-New Hampshire||Present||Introduced||1981||Hoffman (1990)|
|-New Jersey||Absent, Formerly present||1967||Steinbach et al. (2009)||One hatchery positive in the 1980s is no longer in operation. Parasite does not appear to have become established in the wild|
|-New Mexico||Present||Introduced||1987||Hansen et al. (2002)|
|-New York||Present, Widespread||Introduced||1984||Hoffman (1990)|
|-Ohio||Present, Few occurrences||1970||Introduced||1968||Tidd and Tubb (1970)||One private facility reported in 1970; no further information|
|-Oregon||Present, Localized||Introduced||1986||Holt et al. (1987)|
|-Pennsylvania||Present, Widespread||Introduced||1956||Hoffman et al. (1962)||First record in USA confirmed in 1958 following an outbreak at a state hatchery in 1956|
|-Utah||Present, Widespread||Introduced||1991||Invasive||Wilson (1991)|
|-Vermont||Present||Introduced||2002||Steinbach et al. (2009)|
|-Washington||Present, Localized||Introduced||1996||Bartholomew and Reno (2002)|
|-West Virginia||Present, Few occurrences||Introduced||Meyers (1969)||No current information; last detected at a small private hatchery in the 1970s; Last reported: 1970s|
|New Zealand||Present||Introduced||Hewitt and Little (1972)||Although confirmed in 1971, introduction likely occurred prior to 1952|
History of Introduction and SpreadTop of page
M. cerebralis is believed to be indigenous to Europe and Western Russia and to have been introduced elsewhere through movements of subclinically infected fish. In Europe, whirling disease was first detected in Germany in the late 1890s, when rainbow (Oncorhynchus mykiss) and cutthroat (Salvelinus fontinalis) trout, both non-native species, were imported and reared at hatcheries to supplement the culture of native brown trout (Salmo trutta). During the first half of the twentieth century, the parasite spread within Germany and to two Denmark and Finland, but by the 1970s it was reported throughout Europe and the former Soviet Union. It is unclear whether this perceived rapid spread was as a result of the unrestricted transfers of subclinically infected trout that occurred following WWII or if the parasite was already present in the more resistant native brown trout, which then served as a reservoir of infection for the susceptible introduced species. The presence of fish culture facilities on the same rivers where the parasite is detected in natural populations also makes it difficult to determine whether the parasite was introduced or enzootic.
Outside Europe, dissemination was most likely a result of transport of infected fish. It is unknown precisely when introduction of M. cerebralis to North America occurred, but exchanges of live fish, fish eggs, and frozen fish were common between Europe and the US and the parasite was probably introduced unintentionally through the transfer of infected fish or fish products (Hoffman, 1990). The first confirmations of whirling disease occurred nearly simultaneously in Pennsylvania and Nevada in the late 1950s, but suspected infections were present in New York as early as the 1930s. Subsequent spread in the US was largely by interstate movements of subclinically infected fish and through stocking of natural waters. The recent introduction of the parasite into the US is supported by the low level of intraspecific variation between DNA sequences (small subunit ribosomal DNA (ssu rDNA; <1%) and internal transcribed spacer-1 (ITS1; 1.7%)) of European and North American isolates of M. cerebralis (Whipps et al., 2004; Arsan et al., 2007a). For further discussion see Hoffman (1990), Bartholomew and Reno (2002) and Steinbach et al. (2009).
A second highly visible introduction occurred in New Zealand. Clinical disease signs had been reported as early as 1955, but M. cerebralis was not confirmed until 1971. By the time of its detection there was a complete ban on importations of salmonids except in a heat-treated form.
IntroductionsTop of page
|Introduced to||Introduced from||Year||Reason||Introduced by||Established in wild through||References||Notes|
|Natural reproduction||Continuous restocking|
|Nevada||Europe||1950s||Aquaculture (pathway cause)||Yes||No||Hoffman (1990)||Importation of fish resulted in parasite introduction|
|New Zealand||Europe||1950s||Aquaculture (pathway cause)||Yes||No||Hewitt and Little (1972)||Importation of fish eggs resulted in parasite introduction, likely in the packing material|
|Pennsylvania||Europe||1950s||Aquaculture (pathway cause)||Yes||No||Hoffman (1990)||Importation of fish resulted in parasite introduction|
Risk of IntroductionTop of page
The movement of M. cerebralis-infected fish is thought to be the primary vector by which the parasite has spread (Hoffman, 1970, 1990; Hedrick et al., 1998; Bartholomew and Reno, 2002). Salmonid eggs cannot serve as vectors for M. cerebralis as the parasite is not transmitted vertically (O’Grodnick, 1975a), and eggs do not become infected if exposed to triactinomyxons (Markiw, 1991). However, contaminated water or packing material containing eggs could transmit the parasite.
Movement of M. cerebralis-infected fish can occur naturally or through human activities. Legal transfers of infected fish occur primarily as a result of fish stocking activities. Improvements in diagnostic methods have reduced this risk; however, difficulty in timely detection of M. cerebralis infection continues to result in accidental introductions of the parasite. Illegal transfers of M. cerebralis-infected fish are now perhaps the highest-risk human activity spreading the parasite. The construction of ponds on private property has become extremely common, and individuals may stock their ponds by purchase of fish through the private aquaculture industry (Steinbach et al., 2009).
Other pathways for spread of M. cerebralis include movement of water, or sediments containing the parasite, by anglers, boaters, and other recreational enthusiasts. Piscivorous wildlife, including fish, birds and mammals, which ingest M. cerebralis-infected fish, can spread the parasite between drainages. Passage of viable myxospores through the digestive system of piscivorous birds has been demonstrated (Taylor and Lott, 1978; El-Matbouli and Hoffmann, 1991). Other potential means of spread include the release of infected T. tubifex from the aquarium trade (Lowers and Bartholomew, 2003; Hallett et al., 2005, 2006), improper disposal of infected fish parts, use of infected fish parts as bait, and effluent from commercial fish processing (Arsan and Bartholomew, 2008), although these have not been demonstrated.
Pathogen CharacteristicsTop of page
M. cerebralis has two microscopic phenotypically distinct spore types - a triactinomyxon-type actinospore and a myxobolus-type myxospore; the spore is the infectious stage for the next host. It is presporogonic development of the myxospore stage of M. cerebralis in fishes that can cause whirling disease. A comprehensive description of development in the fish host is provided by El-Matbouli et al. (1995). Stages prior to sporogony resemble those of other myxozoans. Myxospores are bilaterally symmetrical, broadly oval in frontal view, broadly lenticular in side view with length 8.7 µm, width 8.2 µm and thickness 6.3 µm (Lom and Hoffman, 1971). Two hard valve cells surround a binucleate sporoplasm and two polar capsules, which each contain a coiled (5-6 turns), extrudable polar filament. Actinospores are triradially symmetrical and anchor shaped once waterborne (they are folded within the worm host). The actinospore is composed of three valve cells that form an axis (~150 µm) and three caudal processes (each ~194 µm) (El-Matbouli and Hoffmann, 1998). Within the apical end of the axis there are three polar capsules that each contain a coiled polar filament (5 turns). Below the polar capsules is a sporoplasm that contains 64 germ cells.
Myxospore valve cells contain a protective complex polysaccharide matrix (Lom and Hoffman, 1971); the actinospore stage is relatively fragile. Myxospores become nonviable after: freezing at -20°C for 7 days, holding at 20°C for 2 months, drying, treating with alkyl dimethyl benzyl ammonium chloride at 1500 mg/L for 10 minutes, a dose of ultraviolet (UV) of 40-480 mJ/cm² and chlorine bleach at 500 mg/L for 15 minutes (Hedrick et al., 2008).
Host AnimalsTop of page
|Animal name||Context||Life stage||System|
|Hucho||Domesticated host, Subclinical, Wild host||Aquatic: Fry||Open water systems/Enhancements and culture-based fisheries (inc. ranching and stock enhacement)|Open water systems/Hard substrate, bottom culture|Enclosed systems/Ponds|Enclosed systems/Raceways / running water ponds|Open water systems/Soft substrate/sediment, bottom culture|
|Oncorhynchus||Domesticated host, Subclinical, Wild host||Aquatic: Fry||Open water systems/Enhancements and culture-based fisheries (inc. ranching and stock enhacement)|Open water systems/Hard substrate, bottom culture|Enclosed systems/Ponds|Enclosed systems/Raceways / running water ponds|Open water systems/Soft substrate/sediment, bottom culture|
|Oncorhynchus mykiss (rainbow trout)|
|Prosopium||Domesticated host, Subclinical, Wild host||Aquatic: Fry||Open water systems/Enhancements and culture-based fisheries (inc. ranching and stock enhacement)|Open water systems/Hard substrate, bottom culture|Enclosed systems/Ponds|Enclosed systems/Raceways / running water ponds|Open water systems/Soft substrate/sediment, bottom culture|
|Salmo||Domesticated host, Subclinical, Wild host||Aquatic: Fry|
|Salvelinus||Domesticated host, Subclinical, Wild host||Aquatic: Fry|
|Thymallus||Domesticated host, Subclinical, Wild host||Aquatic: Fry|
ClimateTop of page
|C - Temperate/Mesothermal climate||Preferred||Average temp. of coldest month > 0°C and < 18°C, mean warmest month > 10°C|
|Cf - Warm temperate climate, wet all year||Preferred||Warm average temp. > 10°C, Cold average temp. > 0°C, wet all year|
|Cs - Warm temperate climate with dry summer||Tolerated||Warm average temp. > 10°C, Cold average temp. > 0°C, dry summers|
|Cw - Warm temperate climate with dry winter||Tolerated||Warm temperate climate with dry winter (Warm average temp. > 10°C, Cold average temp. > 0°C, dry winters)|
|D - Continental/Microthermal climate||Tolerated||Continental/Microthermal climate (Average temp. of coldest month < 0°C, mean warmest month > 10°C)|
|Df - Continental climate, wet all year||Tolerated||Continental climate, wet all year (Warm average temp. > 10°C, coldest month < 0°C, wet all year)|
|Ds - Continental climate with dry summer||Tolerated||Continental climate with dry summer (Warm average temp. > 10°C, coldest month < 0°C, dry summers)|
|Dw - Continental climate with dry winter||Tolerated||Continental climate with dry winter (Warm average temp. > 10°C, coldest month < 0°C, dry winters)|
Latitude/Altitude RangesTop of page
|Latitude North (°N)||Latitude South (°S)||Altitude Lower (m)||Altitude Upper (m)|
Notes on Natural EnemiesTop of page
No specific natural enemies for M. cerebralis have been identified. However, it is assumed that once the integrity of the spore has been compromised, the organism is vulnerable to degradation by other microbiota. Non-target hosts aid in the reduction of infectious stages. For example, actinospores will attach to non-salmonids (Kallert et al., 2009) and thus be deactivated. Similarly, resistant lineages of T. tubifex will consume and deactivate myxospores, thus preventing infectious stages reaching susceptible lineages (Beauchamp et al., 2006).
Means of Movement and DispersalTop of page
Both spore stages are disseminated naturally in water (Steinbach et al., 2009).
The parasite can be disseminated both locally and over long distances through the movement of infected salmonid fish (Hoffman, 1990). Natural fish migrations may move the parasite locally or stocking of subclinically infected fish may result in long distance and local dissemination of the parasite. Piscivorous birds and wildlife may also disseminate myxospores but the likelihood of this occurrence is highest over short distances (Koel et al., 2010). The release of infected T. tubifex from the aquarium trade (Lowers and Bartholomew, 2003; Hallett et al., 2005, 2006) could also result in release of the parasite.
Myxospores in sediment can be accidentally transported on anglers' waders (Gates et al., 2008). Other means of spread could include the improper disposal of infected fish parts as bait and the discharge of effluent from commercial fish processing (Arsan and Bartholomew, 2008), although these have not been demonstrated.
Pathway CausesTop of page
|Aquaculture||Yes||Yes||Bartholomew and Reno, 2002|
|Fisheries||Yes||Yes||Bartholomew and Reno, 2002|
|Hitchhiker||Potential movement on anglers' gear||Yes||Gates et al., 2008|
|Interbasin transfers||Stocking of subclincally infected fish||Yes||Yes||Bartholomew and Reno, 2002|
|Interconnected waterways||Natural fish migration||Yes||Bartholomew and Reno, 2002|
|Stocking||Stocking of subclinically infected fish||Yes||Yes||Bartholomew and Reno, 2002|
Pathway VectorsTop of page
|Aquaculture stock||Most frequent means of dissemination. Parasite not easily detected||Yes||Yes||Hoffman, 1990|
|Clothing, footwear and possessions||Myxospores in sediment can be moved on anglers' waders||Yes||Gates et al., 2008|
|Host and vector organisms||Dissemination mainly through movement of salmonoid fish; possibly by wildlife over shorter distances||Yes||Yes||Koel et al., 2010|
|Water||Both spore stages are disseminated naturally in water||Yes||Steinbach et al., 2009|
Economic ImpactTop of page
Historically, the economic impacts of whirling disease have been in relation to the loss of cultured trout. In Europe and the US, both private and publicly owned fish culture operations have sustained large financial losses costs because of M. cerebralis. The parasite has impacted fish culture by causing fish mortalities and reducing fitness, necessitating the destruction of infected fish, requiring disinfection and renovation of facilities, causing the quarantine and closure of facilities and reducing the number of fish available for sale and stocking. In the US, facilities in Utah, California and Colorado were quarantined while millions of dollars were spent to disinfect and renovate them, or they were forced to close when the costs of parasite removal were too great. In 2005, the total value of Utah trout sales dropped almost 30% or approximately $220,000 from the previous year for reasons that included the closure of six privately owned facilities as a result of M. cerebralis detection (House, 2006). In Colorado, the state spent more than $11 million to modernize hatcheries for whirling disease prevention and management between 1987 and 2006 and the federal government completed a multi-million dollar renovation of a National Fish Hatchery to eliminate M. cerebralis (Steinbach et al., 2009). In Europe, although epizootics of whirling disease were widespread in the past century, changes in hatchery practices have greatly minimized losses and the disease is no longer considered a major problem in private fish culture. This transition involved considerable costs but there are no financial reports to support this.
Economic impacts due to the loss of wild fish are often associated with recreational trout fishing. When wild trout population declines were first linked to whirling disease, financial losses due to declines in recreational fishing and tourism were expected. Despite these concerns, no large impact has been documented. In an evaluation of recreational fisheries in Montana and Colorado, no negative effects upon angler satisfaction and local fishing economics could be detected five years after whirling disease caused severe declines in wild trout population (Duffield et al., 1999).
Environmental ImpactTop of page
Impact on Biodiversity
There is evidence of change in the composition of local trout populations in the Madison River, Montana USA, where rainbow trout numbers declined but overall trout populations remained constant because of the increase in brown trout numbers. However, both of these species are introduced in that system. Two native fish in the Rocky Mountain region of the USA, Mountain whitefish (Prosopium williamsoni) and cutthroat trout (Oncorhynchus clarki), may undergo local population declines as a result of infection (Pierce et al. 2011; Koel et al. 2006).
Threatened SpeciesTop of page
Risk and Impact FactorsTop of page Invasiveness
- Proved invasive outside its native range
- Abundant in its native range
- Has propagules that can remain viable for more than one year
- Reproduces asexually
- Changed gene pool/ selective loss of genotypes
- Host damage
- Negatively impacts aquaculture/fisheries
- Reduced native biodiversity
- Threat to/ loss of endangered species
- Threat to/ loss of native species
- Negatively impacts trade/international relations
- Parasitism (incl. parasitoid)
- Difficult to identify/detect as a commodity contaminant
- Difficult to identify/detect in the field
- Difficult/costly to control
ReferencesTop of page
Adkison MA, Kelley GO, Leutenegger CM, Hedrick RP, 2002. Proceedings of the 8th Annual Whirling Disease Symposium, Denver, Colorado. Bozeman, Montana, USA: Whirling Disease Foundation, 7-8 pp.
American Fisheries Society-Fish Health Section, 2012. Fish Health Section blue book: Suggested procedures for the detection and identification of certain finfish and shellfish pathogens, 2012 edition. Maryland, USA: American Fisheries Society-Fish Health Section.
Andree KB, MacConnell E, Hedrick RP, 1998. A nested polymerase chain reaction for the detection of genomic DNA of Myxobolus cerebralis in rainbow trout Oncorhynchus mykiss. Diseases of Aquatic Organisms, 34(2):145-154.
Arsan EL, Atkinson SD, Hallett SL, Meyers T, Bartholomew JL, 2007. Expanded geographical distribution of Myxobolus cerebralis: first detections from Alaska. Journal of Fish Diseases, 30(8):483-491. http://www.blackwell-synergy.com/loi/jfd
Arsan EL, Bartholomew JL, 2008. Potential for dissemination of the nonnative salmonid parasite Myxobolus cerebralis in Alaska. Journal of Aquatic Animal Health, 20(3):136-149. http://afsjournals.org/doi/abs/10.1577/H07-016.1
Arsan EL, Hallett SL, Bartholomew JL, 2007. Tubifex tubifex from Alaska: distribution and susceptibility to Myxobolus cerebralis. Journal of Parasitology, 93:1332-1342.
Baerwald MR, 2013. Temporal expression patterns of rainbow trout immune-related genes in response to Myxobolus cerebralis exposure. Fish & Shellfish Immunology, 35(3):965-971. http://www.sciencedirect.com/science/journal/10504648
Baldwin TJ, Vincent ER, Silflow RM, Stanek D, 2000. Myxobolus cerebralis infection in rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta) exposed under natural stream conditions. Journal of Veterinary Diagnostic Investigation, 12(4):312-321.
Barney P, Anderson D, Walker P, 1988. Whirling disease identified in Colorado. American Fisheries Society Fish Health Section Newsletter, 16(1). Maryland, USA: American Fisheries Society, 3.
Bartholomew JL, 2012. Myxobolus cerebralis. In: Handbook of Global Freshwater Invasive Species [ed. by Francis, R.]. London, UK: Earthscan.
Bartholomew JL, Reno PW, 2002. The history and dissemination of whirling disease. In: Whirling disease: Reviews and current topics, Symposium 29 [ed. by Bartholomew, J. L. \Wilson, J. C.]. Maryland, USA: American Fisheries Society, 3-24 pp.
Beauchamp KA, El-Matbouli M, Gay M, Georgiadis MP, Nehring RB, Hedrick RP, 2006. The effect of cohabitation of Tubifex tubifex (Oligochaeta: Tubificidae) populations on infections to Myxobolus cerebralis (Myxozoa: Myxobolidae). Journal of Invertebrate Pathology, 91(1):1-8. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WJV-4HNYMVS-1&_user=3891418&_handle=V-WA-A-W-AZ-MsSAYZW-UUA-U-AAZAVUDDAW-AACYEYYCAW-AVWDBCUUB-AZ-U&_fmt=full&_coverDate=01%2F31%2F2006&_rdoc=3&_orig=browse&_srch=%23toc%236888%232006%23999089998%23614245!&_cdi=6888&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=9ef5de2157615e94f64ed218c81f820f
Beauchamp KA, Gay M, Kelley GO, El-Matbouli M, Kathman RD, Nehring RB, Hedrick RP, 2002. Prevalence and susceptibility of infection to Myxobolus cerebralis, and genetic differences among populations of Tubifex tubifex. Diseases of Aquatic Organisms, 51(2):113-121.
Bogdanova EA, 1960. Natural habitat of the myxosporidian (Myxosoma cerebralis, whirling disease) at Sakhalin (S. Russia). Doklady Akademii Nauk SSSR, 134:1501-1503.
Bogdanova EA, 1968. Modern data on the distribution and biology of Myxosoma cerebralis (Protozoa, Cnidosporidia) as agent of whirling disease of salmonids. Bulletin de l'office International des Epizooties, 69. 1499-1506 pp.
Boreham RE, Hendrick S, O'Donoghue PJ, Stenzel DJ, 1998. Incidental finding of Myxobolus spores (Protozoa: Myxozoa) in stool samples from patients with gastrointestinal symptoms. Journal of Clinical Microbiology, 36(12):3728-3730.
Bruhl L, 1926. Report on the fisheries conference in Königsberg in Prussia from 2 July to 1 August. (Bericht über die Fischereitagung in Königsberg i. Pr. Von 2. Juli bis 1 August.) Fischereizeitung, 29:813-815.
Cavender WP, Wood JS, Powell MS, Overturf K, Cain KD, 2004. Real-time quantitative polymerase chain reaction (QPCR) to identify Myxobolus cerebralis in rainbow trout Oncorhynchus mykiss. Diseases of Aquatic Organisms, 60(3):205-213.
Christensen NO, 1972. Panel review on myxosomiasis (Whirling disease in salmonid fishes). FI:EIFAC 72/SC II-Symposium, 8(6).
Cordero-del-Campillo MA, Diez E, Alvarez-Pellitero MP, Rojo-Vazquez FA, 1975. Torneo de la trucha (Myxosomosis). (Torneo de la trucha (Myxosomosis).) Revisión. Suplemento Cientifico del Boletin Informative Consejo General de Colegio Veterinarios de España, 201. 5-28.
Duffield JW, Patterson, DA, Neher C, Loomis JB, 1999. Economic consequences of whirling disease in Montana and Colorado trout fisheries. Whirling Disease Initiative Reports. Montana, USA: Montana Water Center, Montana State University.
Dyk V, 1954. Nemoci nasich ryb (Diseases of the fish). Prague, Czech Republic: Nakladatelstvi CSAV, 392 pp.
El-Matbouli M, Hoffmann RW, 1991. Effects of freezing, aging, and passage through the alimentary canal of predatory animals on the viability of Myxobolus cerebralis spores. Journal of Aquatic Animal Health, 3(4):260-262.
El-Matbouli M, Hoffmann RW, 1998. Light and electron microscopic studies on the chronological development of Myxobolus cerebralis to the actinosporean stage in Tubifex tubifex. International Journal for Parasitology, 28(1):195-217.
El-Matbouli M, Hoffmann RW, Mandok C, 1995. Light and electron microscopic observations on the route of the triactinomyxon-sporoplasm of Myxobolus cerebralis from epidermis into rainbow trout cartilage. Journal of Fish Biology, 46(6):919-935.
El-Matbouli M, Soliman H, 2005. Development of a rapid assay for the diagnosis of Myxobolus cerebralis in fish and oligochaetes using loop-mediated isothermal amplification. Journal of Fish Diseases, 28(9):549-557.
Engelking HM, 2002. Potential for introduction of Myxobolus cerebralis into the Deschutes River watershed in central Oregon from adult anadromous salmonids. In: Whirling disease: Reviews and current topics, Symposium 29 [ed. by Bartholomew, J. L. \Wilson, J. C.]. Maryland, USA: American Fisheries Society, 25-31 pp.
Gates KK, Guy CS, Zale AV, Horton TB, 2008. Adherence of Myxobolus cerebralis myxospores to waders: implications for disease dissemination. North American Journal of Fisheries Management, 28(5):1453-1458.
Gonzalez-Lanza M, Alvarez-Pellitero MP, 1984. Myxobolus farionis n.sp and M. ibericus n. of Salmo trutta f. fario from the Duero basin (NW Spain). Description and population dynamics. Angewandte Parasitologie, 25:181-189.
Hallett SL, Atkinson SD, Erséus C, El-Matbouli M, 2005. Dissemination of triactinomyxons (Myxozoa) via oligochaetes used as live food for aquarium fishes. Diseases of Aquatic Organisms, 65(2):137-152.
Hallett SL, Atkinson SD, Erséus C, El-Matbouli M, 2006. Myxozoan parasites disseminated via oligochaete worms as live food for aquarium fishes: descriptions of aurantiactinomyxon and raabeia actinospore types. Diseases of Aquatic Organisms, 69(2/3):213-225.
Hallett SL, Bartholomew JL, 2008. Effects of water flow on the infection dynamics of Myxobolus cerebralis. Parasitology, 135(3):371-384. http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1757324&fulltextType=RA&fileId=S0031182007003976
Hallett SL, Bartholomew JL, 2012. Chapter 8: Myxobolus cerebralis and Ceratomyxa shasta. In: Fish Parasites: Pathobiology and Protection [ed. by Woo, P. T. K. \Buchmann, K.]. Oxfordshire, UK: CABI.
Halliday MM, 1973. Studies on Myxosoma cerebralis, a parasite of salmonids. II. The development and pathology of Myxosoma cerebralis in experimentally infected rainbow trout (Salmo gairdneri) fry reared at different water temperatures. Nordisk Veterinaermedicin, 25:349-358.
Hansen RW, Bell L, Sloane M, Evans L, 2002. Whirling disease investigations. Statewide Fisheries Management Grant F-63-R. Santa Fe, New Mexico, USA: Department of Game and Fish.
Hastein T, 1971. The occurrence of whirling disease (Myxosomiasis) in Norway. Acta Veterinaria Scandinavica, 12:297-299.
Hauck AK, Landin S, Wavra S, 1988. Whirling disease in Idaho. American Fisheries Society Fish Health Section Newsletter, 16(2):5.
Hedrick RP, El-Matbouli M, 2002. Recent advances with taxonomy, life cycle, and development of Myxobolus cerebralis in the fish and oligochaete hosts. In: Whirling disease: Reviews and current topics, Symposium 29 [ed. by Bartholomew, J. L. \Wilson, J. C.]. Maryland, USA: American Fisheries Society, 45-53 pp.
Hedrick RP, El-Matbouli M, Adkison MA, MacConnell E, 1998. Whirling disease: re-emergence among wild trout. Immunological Reviews, 166:65-376.
Hedrick RP, McDowell TS, Gay M, Marty GD, Georgiadis MP, MacConnell E, 1999. Comparative susceptibility of rainbow trout Oncorhynchus mykiss and brown trout Salmo trutta to Myxobolus cerebralis, the cause of salmonid whirling disease. Diseases of Aquatic Organisms, 37(3):173-183.
Hedrick RP, McDowell TS, Marty GD, Mukkatira K, Antonio DB, Andree KB, Bukhari Z, Clancy T, 2000. Ultraviolet irradiation inactivates the waterborne infective stages of Myxobolus cerebralis: a treatment for hatchery water supplies. Diseases of Aquatic Organisms, 42(1):53-59.
Hedrick RP, McDowell TS, Mukkatira K, MacConnell E, Petri B, 2008. Effects of freezing, drying, ultraviolet irradiation, chlorine, and quaternary ammonium treatments on the infectivity of myxospores of Myxobolus cerebralis for Tubifex tubifex. Journal of Aquatic Animal Health, 20(2):116-125. http://afsjournals.org/doi/abs/10.1577/H07-042.1
Hewitt GC, Little RW, 1972. Whirling disease in New Zealand trout caused by Myxosoma cerebralis (Hofer, 1903) (Protozoa:Myxosporidia). New Zealand Journal of Marine and Freshwater Research, 6:1-10.
Hnath JG, 1970. Whirling disease in the state of Michigan. Second International Conference of Parasitology. Abstract #273, September 6-12, Washington DC. Journal of Parasitology, 56:149-150 pp.
Hofer B, 1903. About the rotational disease of rainbow trout. (Ueber die Drehkrankheit der Regenbogenforelle.) Allgemeine Fischerei Zeitung, 28:7-8.
Hoffman GL, 1974. Disinfection of contaminated water by ultraviolet irradiation, with emphasis on whirling disease (Myxosoma cerebralis) and its effect on fish. Transactions of the American Fisheries Society, 103(No.3):541-550.
Hoffman GL, 1999. Parasites of North American Freshwater Fishes [ed. by 2nd]. Ithaca, New York, USA: Cornell University Press, 71 pp.
Hoffman GL, Dunbar CE, Bradford A, 1962. Whirling disease of trouts caused by Myxosoma cerebralis in the United States. United States Fish and Wildlife Service, Special Scientific Report, Fisheries No. 427, 427. Washington DC, USA: US Fish and Wildlife Service.
Hogge CI, Campbell MR, Johnson KA, 2008. A new species of myxozoan (Myxosporea) from the brain and spinal cord of rainbow trout (Oncorhynchus mykiss) from Idaho. Journal of Parasitology, 94(1):218-222. http://asp.unl.edu
Holt RA, Amandi A, Banner CR, Kreps TD, 1987. Whirling disease in Oregon. American Fisheries Society Fish Health Section Newsletter, 15(1).
House D, 2006. Utah sales of trout, eggs dipped 29 percent in 2005. Salt Lake City, Utah, USA: The Salt Lake Tribune.
Johansson N, 1966. First identification of Myxosoma cerebralis in Sweden. Swedish Salmon Research Institute. Report LFI. 94 pp.
Kallert DM, Eszterbauer E, Grabner D, El-Matbouli M, 2009. In vivo exposure of susceptible and non-susceptible fish species to Myxobolus cerebralis actinospores reveals non-specific invasion behaviour. Diseases of Aquatic Organisms, 84(2):123-130.
Kawai T, Sekizuka T, Yahata Y, Kuroda M, Kumeda Y, Iijima Y, Kamata Y, Sugita-Konishi Y, Ohnishi T, 2012. Identification of Kudoa septempunctata as the causative agent of novel food poisoning outbreaks in Japan by consumption of Paralichthys olivaceus in raw fish. Clinical Infectious Diseases, 54(8):1046-1052. http://cid.oxfordjournals.org/
Kelley GO, Zagmutt-Vergara FJ, Leutenegger CM, Myklebust KA, Adkison MA, McDowell TS, Marty GD, Kahler AL, Bush AL, Gardner IA, Hedrick RP, 2004. Evaluation of five diagnostic methods for the detection and quantification of Myxobolus cerebralis. Journal of Veterinary Diagnostic Investigation, 16(3):202-211.
Kent ML, Margolis L, Corliss JO, 1994. The demise of a class of protists: taxonomic and nomenclatural revisions proposed for the protist phylum Myxozoa Grassé, 1970. Canadian Journal of Zoology, 72(5):932-937.
Kocylowski B, 1953. Choroby ryb i ich Knalkanie. Gospodarka ryb., 5:24-26.
Koel TM, Kerans BL, Barras SC, Hanson KC, Wood JS, 2010. Avian piscivores as vectors for Myxobolus cerebralis in the Greater yellowstone ecosystem. Transactions of the American Fisheries Society, 139(4):976-988. http://www.informaworld.com/smpp/content~db=all~content=a932191468~frm=titlelink
Koel TM, Mahony DL, Kinnan KL, Rasmussen C, Hudson CJ, Murcia S, Kerans BL, 2006. Myxobolus cerebralis in native cutthroat trout of the Yellowstone Lake ecosystem. Journal of Aquatic Animal Health, 18(3):157-175.
Kostova T, Chikova V, 2011. Myxobolosis in rainbow trout. Sbornik dokladi ot nauchnata konferentsiya: Traditsii i s'vrenmennost v'v veterinarnata meditsina, 2011 [Proceedings. Traditional and contemporary veterinary medicine, Bulgaria, 2011.], 388-395.
Lebbad M, Willcox M, 1998. Spores of Henneguya salminicola in human stool specimens. Journal of Clinical Microbiology, 36:182.
Li SQ, 1989. Main fish diseases and their control. In: Integrated Fish Farming in China [ed. by NACA (Network of Aquaculture Centres in Asia and the Pacific)]. Bangkok, Thailand: Network of Aquaculture Centres in Asia and the Pacific. [NACA Technical Manual 7. A World Food Day Publication of the Network of Aquaculture Centres in Asia and the Pacific.] http://www.fao.org/docrep/field/003/ac264e/AC264E07.htm#ch6
Lowers JM, Bartholomew JL, 2003. Detection of myxozoan parasites in oligochaetes imported as food for ornamental fish. Journal of Parasitology, 89:84-91.
MacConnell E, Vincent ER, 2002. Review: The effects of Myxobolus cerebralis on the salmonid host. In: Whirling disease: Reviews and current topics, Symposium 29 [ed. by Bartholomew, J. L. \Wilson, J. C.]. Maryland, USA: American Fisheries Society, 95-107 pp.
Margaritov NM, 1960. Whirling disease of trout in DRS-Samokov. Ribno stopanstvo 2:15-18. Sofia.
Markiw ME, 1992. Salmonid whirling disease. Leaflet 17. Washington D.C, USA: US Fish and Wildlife Service.
Markiw ME, Wolf K, 1983. Myxosoma cerebralis (Myxozoa: Myxosporea) etiologic agent of salmonid whirling disease requires tubificid worm (Annelida: Oligochaeta) in its life cycle. Journal of Protozoology, 30(3):561-564.
Martínez de Velasco G, Rodero M, Cuéllar C, Chivato T, Mateos JM, Laguna R, 2008. Skin prick test of Kudoa sp. antigens in patients with gastrointestinal and/or allergic symptoms related to fish ingestion. Parasitology Research, 103(3):713-715. http://www.springerlink.com/content/2q5502151t563668/?p=c4e2a802032f468d88c1d867112c88df&pi=32
McClelland RS, Murphy DM, Cone DK, 1997. Report of spores of Henneguya salminicola (Myxozoa) in human stool specimens: possible source of confusion with human spermatozoa. Journal of Clinical Microbiology, 35(11):2815-2818.
Meyers TU, 1969. Whirling disease. FAO Aquaculture Bulletin, 2:13.
Mitchum DL, 1995. Parasites of Fish in Wyoming. Wyoming, USA: Wyoming Game and Fish Department, 304 pp.
Moncada LI, López MC, Murcia MI, Nicholls S, León F, Guío OL, Corredor A, 2001. Myxobolus sp., another opportunistic parasite in immunosuppressed patients? Journal of Clinical Microbiology, 39(5):1938-1940.
Murcia S, Kerans BL, MacConnell E, Koel TM, 2011. Correlation of environmental attributes with histopathology of native Yellowstone cutthroat trout naturally infected with Myxobolus cerebralis. Diseases of Aquatic Organisms, 93(3):225-234.
Nehring RB, Thompson KG, Hebein S, 1998. Impacts of whirling disease on wild trout populations in Colorado. In: Transactions of the Sixty-third North American Wildlife and Natural Resources Conference, Orlando, Florida, USA, 20-24 March, 1998 [ed. by Wadsworth, K. G.]. Washington, USA: Wildlife Management Institute, 82-94.
Nehring RB, Thompson KG, Taurman KA, Shuler DL, 2002. Laboratory studies indicating that living brown trout Salmo trutta expel viable Myxobolus cerebralis myxospores. In: Whirling disease: Reviews and current topics. American Fisheries Society, Symposium 29 [ed. by Bartholomew, J. L. \Wilson, J. C.]. Maryland, USA: American Fisheries Society.
Nesnidal MP, Helmkampf M, Bruchhaus I, El-Matbouli M, Hausdorf B, 2013. Agent of whirling disease meets orphan worm: phylogenomic analyses firmly place Myxozoa in Cnidaria. PLoS ONE, 8(1):e54576. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054576
O'Grodnick JJ, Gustafson CC, 1974. A study of the transmission, life history, and control of whirling disease of trout. Federal Aid to Fish Restoration Progress Report F-35-R-6. Washington DC, USA: US Fish and Wildlife Service.
Pierce R, Davidson M, Podner C, 2012. Spawning behavior of mountain whitefish and co-occurrence of Myxobolus cerebralis in the Blackfoot River basin, Montana. Transactions of the American Fisheries Society, 141(3):720-730. http://www.tandfonline.com/doi/full/10.1080/00028487.2012.675900
Preudhomme JG, 1970. Whirling disease of trout in Morocco. FAO Aquaculture Bulletin, 2:14.
Pugachev ON, Khokhlov PP, 1979. Myxosporean parasites of genus Myxobolus-parasites of the salmonids head and spinal brain. Systematic and ecology of fish from continental water bodies of the Far East region. Vladivostok. 137-139 pp.
Schisler GJ, Bergersen EP, Walker PG, Wood J, Epp JK, 2001. Comparison of single-round polymerase chain reaction (PCR) and pepsin-trypsin digest (PTD) methods for detection of Myxobolus cerebralis. Diseases of Aquatic Organisms, 45(2):109-114.
Schuberg A, Schroder O, 1905. Myxosporidien aus dem nervensystem und der haut der bachforelle. Archiv fur Protistenkunde, 6:46-60.
Scolari C, 1954. Sull'impiego dello stovarsolo nelle profilassi del 'capostan' o 'lentosporiasi' delle trote d'allevamento. La Clinica Veterinaria, 77:50-53.
Sollid SA, Lorz HV, Stevens DG, Bartholomew JL, 2003. Age-dependent susceptibility of Chinook salmon to Myxobolus cerebralis and effects of sustained parasite challenges. Journal of Aquatic Animal Health, 15(2):136-146.
Staton L, Erdahl D, El-Matbouli M, 2002. Efficacy of Fumagillin and TNP-470 to prevent experimentally induced whirling disease in rainbow trout Oncorhynchus mykiss. In: Whirling disease: Reviews and current topics, Symposium 29 [ed. by Bartholomew, J. L. \Wilson, J. C.]. Maryland, USA: American Fisheries Society, 239-247 pp.
Steinbach E, Stromberg LC, Ryce EKN, Bartholomew JL, 2009. Whirling disease in the United States. A summary of progress in research and management 2009. Virginia, USA: Trout Unlimited Whirling Disease Foundation, 61 pp.
Tidd WM, Tubb RA, 1970. Investigations of whirling disease in Ohio. Journal of Parasitology, 56:632.
Tomasec I, 1960. Lutte contre les principles maladies infectieuses des poisons. Bulletin of the Office International des Epizootics, 54:55-57.
Uspenskaya AV, 1955. Biology, distribution and economic importance of Myxosoma cerebralis, the causative agent of whirling disease of trout. Lectures of the Academy of Science USSR, 105:1132-1135.
Uspenskaya AV, 1957. The ecology and spreading of the pathogen of trout whirling disease-Myxosoma cerebralis (Höfer 1903, Plehn 1905) in the fish ponds of the Soviet Union. All-Union Research Institute of Lake and River Fishery, 42:47-55.
Vanco F, 1952. Contribution á l'étude de la pathologie des alevins de truits. Paris, France: Foulon.
Vincent ER, 1996. Whirling disease and wild trout: The Montana experience. Fisheries, 21:32-33.
Wagner E, 2002. Review: Whirling disease prevention, control, and management: A review. American Fisheries Society, Bethesda, Maryland, pp. In: Whirling disease: Reviews and current topics, Symposium 29 [ed. by Bartholomew, J. L. \Wilson, J. C.]. Maryland, USA: American Fisheries Society, 217-225 pp.
Walker PG, Nehring RB, 1995. An investigation to determine the cause(s) of the disappearance of young wild rainbow trout in the Upper Colorado River, in Middle Park, Colorado. Colorado, USA: Colorado Division of Wildlife, 134 pp.
Whipps CM, El-Matbouli M, Hedrick RP, Blazer V, Kent ML, 2004. Myxobolus cerebralis internal transcribed spacer (ITS-1) sequences support recent spread of the parasite to North America and within Europe. Diseases of Aquatic Organisms, 60(2):105-108.
Whirling Disease Initiative, 2014. Whirling Disease Initiative. Montana, USA: Montana Water Center. http://whirlingdisease.montana.edu/default.asp
Wilson JC, 1991. Whirling disease comes to Utah. The Ichthyogram, Newsletter of the Fisheries Experiment Station, Utah Division of Wildlife Resources, 2. Utah, USA: Utah Division of Wildlife Resources, 1-2.
Wyk GF van, 1968. Annual report No. 24, 1967. Jokershoek Hatchery, Division of Inland Fisheries, 24. Province of Good Hope, Republic of South Africa: Department of Nature Conservation.
Yasutake WT, Wolf H, 1970. Occurrence of whirling disease of trout in the western United States. Second International Congress of Parasitology. September 6-12. Washington, DC. Journal of Parasitology, 56:375-376.
Yasutake WT, Wood EM, 1957. Some myxosporidia found in Pacific Northwest salmonids. Journal of Parasitology, 43:633-642.
Yoder WG, 1972. The spread of Myxosoma cerebralis into natural trout populations in Michigan. Progressive Fish-Culturist, 43:103-106.
Zielinski CM, Lorz HV, Bartholomew JL, 2010. Detection of Myxobolus cerebralis in the lower Deschutes River basin, Oregon, USA. North American Journal of Fishery Management, 30:1032-1040.
Arsan E L, Atkinson S D, Hallett S L, Meyers T, Bartholomew J L, 2007. Expanded geographical distribution of Myxobolus cerebralis: first detections from Alaska. Journal of Fish Diseases. 30 (8), 483-491. http://www.blackwell-synergy.com/loi/jfd DOI:10.1111/j.1365-2761.2007.00834.x
Barney P, Anderson D, Walker P, 1988. Whirling disease identified in Colorado. In: American Fisheries Society Fish Health Section Newsletter, 16 (1) Maryland, USA: American Fisheries Society. 3.
Bartholomew JL, Reno PW, 2002. The history and dissemination of whirling disease. In: Whirling disease: Reviews and current topics, Symposium 29, [ed. by Bartholomew JL, Wilson JC]. Maryland, USA: American Fisheries Society. 3-24.
Bogdanova EA, 1960. Natural habitat of the myxosporidian (Myxosoma cerebralis, whirling disease) at Sakhalin (S. Russia). In: Doklady Akademii Nauk SSSR, 134 1501-1503.
Bogdanova EA, 1968. Modern data on the distribution and biology of Myxosoma cerebralis (Protozoa, Cnidosporidia) as agent of whirling disease of salmonids. In: Bulletin de l'office International des Epizooties, 69 1499-1506.
Bruhl L, 1926. Report on the fisheries conference in Königsberg in Prussia from 2 July to 1 August. (Bericht über die Fischereitagung in Königsberg i. Pr. Von 2. Juli bis 1 August). In: Fischereizeitung, 29 813-815.
CABI, Undated. Compendium record. Wallingford, UK: CABI
CABI, Undated a. CABI Compendium: Status inferred from regional distribution. Wallingford, UK: CABI
CABI, Undated b. CABI Compendium: Status as determined by CABI editor. Wallingford, UK: CABI
Cordero del Campillo M, Escudero Diez A, Alvarez Pellitero M P, Rojo Vazquez F A, 1975. [Whirling disease of trout (Myxosoma cerebralis infection). A review]. (Torneo de la trucha (myxosomosis).). Suplemento Cientifico del Boletin Informativo. Consejo General de Colegios Veterinarios de Espana. 5-28.
Dyk V, 1954. Diseases of the fish. (Nemoci nasich ryb)., Prague, Czech Republic: Nakladatelstvi CSAV. 392 pp.
Hansen RW, Bell L, Sloane M, Evans L, 2002. Whirling disease investigations. In: Statewide Fisheries Management Grant F-63-R, Santa Fe, New Mexico, USA: Department of Game and Fish.
Hastein T, 1971. The occurrence of whirling disease (Myxosomiasis) in Norway. In: Acta Veterinaria Scandinavica, 12 297-299.
Hauck AK, Landin S, Wavra S, 1988. Whirling disease in Idaho. In: American Fisheries Society Fish Health Section Newsletter, 16 (2) 5.
Hewitt GC, Little RW, 1972. Whirling disease in New Zealand trout caused by Myxosoma cerebralis (Hofer, 1903) (Protozoa:Myxosporidia). In: New Zealand Journal of Marine and Freshwater Research, 6 1-10.
Hnath JG, 1970. Whirling disease in the state of Michigan. In: Second International Conference of Parasitology, 56 Washington DC, Journal of Parasitology. 149-150.
Hofer B, 1903. About the rotational disease of rainbow trout. (Ueber die Drehkrankheit der Regenbogenforelle). In: Allgemeine Fischerei Zeitung, 28 7-8.
Hoffman GL, Dunbar CE, Bradford A, 1962. Whirling disease of trouts caused by Myxosoma cerebralis in the United States. In: United States Fish and Wildlife Service, Special Scientific Report, 427 Washington DC, USA: US Fish and Wildlife Service. 427.
Holt RA, Amandi A, Banner CR, Kreps TD, 1987. Whirling disease in Oregon. In: American Fisheries Society Fish Health Section Newsletter, 15 (1)
Johansson N, 1966. First identification of Myxosoma cerebralis in Sweden. In: Report LFI, Swedish Salmon Research Institute. 94 pp.
Kocylowski B, 1953. (Choroby ryb i ich Knalkanie). In: Gospodarka ryb, 5 24-26.
Margaritov NM, 1960. Whirling disease of trout in DRS-Samokov. In: Ribno stopanstvo, 2 Sofia, 15-18.
Meyers TU, 1969. Whirling disease. In: FAO Aquaculture Bulletin, 2 13.
Mitchum DL, 1995. Parasites of Fish in Wyoming., Wyoming, USA: Wyoming Game and Fish Department. 304 pp.
Preudhomme JG, 1970. Whirling disease of trout in Morocco. In: FAO Aquaculture Bulletin, 2 14.
Scolari C, 1954. (Sull'impiego dello stovarsolo nelle profilassi del 'capostan' o 'lentosporiasi' delle trote d'allevamento). In: La Clinica Veterinaria, 77 50-53.
Steinbach E, Stromberg LC, Ryce EKN, Bartholomew JL, 2009. Whirling disease in the United States. In: A summary of progress in research and management 2009, Virginia, USA: Trout Unlimited Whirling Disease Foundation. 61 pp.
Tidd WM, Tubb RA, 1970. Investigations of whirling disease in Ohio. In: Journal of Parasitology, 56 632.
Tomasec I, 1960. (Lutte contre les principles maladies infectieuses des poisons). In: Bulletin of the Office International des Epizootics, 54 55-57.
Uspenskaya AV, 1955. Biology, distribution and economic importance of Myxosoma cerebralis, the causative agent of whirling disease of trout. In: Lectures of the Academy of Science USSR, 105 1132-1135.
Uspenskaya AV, 1957. The ecology and spreading of the pathogen of trout whirling disease-Myxosoma cerebralis (Höfer 1903, Plehn 1905) in the fish ponds of the Soviet Union. In: All-Union Research Institute of Lake and River Fishery, 42 47-55.
Vanco F, 1952. (Contribution á l'étude de la pathologie des alevins de truits)., Paris, France: Foulon.
Vincent ER, 1996. Whirling disease and wild trout: The Montana experience. In: Fisheries, 21 32-33.
Walker PG, Nehring RB, 1995. An investigation to determine the cause(s) of the disappearance of young wild rainbow trout in the Upper Colorado River, in Middle Park, Colorado., Colorado, USA: Colorado Division of Wildlife. 134 pp.
Wilson JC, 1991. Whirling disease comes to Utah. In: The Ichthyogram, Newsletter of the Fisheries Experiment Station, Utah Division of Wildlife Resources, 2 Utah, USA: Utah Division of Wildlife Resources. 1-2.
Wyk GF van, 1968. Annual report No. 24, 1967. In: Jokershoek Hatchery, Division of Inland Fisheries, Province of Good Hope, Republic of South Africa: Department of Nature Conservation. 24.
Yasutake WT, Wolf H, 1970. Occurrence of whirling disease of trout in the western United States. Second International Congress of Parasitology. September 6-12. Washington, DC. In: Journal of Parasitology, 56 375-376.
Yoder WG, 1972. The spread of Myxosoma cerebralis into natural trout populations in Michigan. In: Progressive Fish-Culturist, 43 103-106.
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Draft datasheet under review
ContributorsTop of page
18/10/2013 Original text by:
Jerri Bartholomew, Dept. of Microbiology, Nash Hall 220, Oregon State University, Corvallis, Oregon 97331, USA
Sascha Hallet, Dept. of Microbiology, Nash Hall 220, Oregon State University, Corvallis, Oregon 97331, USA
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