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pulmonary adenomatosis

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pulmonary adenomatosis

Summary

  • Last modified
  • 21 November 2019
  • Datasheet Type(s)
  • Animal Disease
  • Preferred Scientific Name
  • pulmonary adenomatosis
  • Pathogens
  • jaagsiekte sheep retrovirus
  • Overview
  • Sheep pulmonary adenomatosis (SPA) is a contagious disease of sheep produced by a tumour of type II alveolar and Clara cells in the lungs. The disease has been occasionally recorded naturally in goats and mouflon. SPA...

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Pictures

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PictureTitleCaptionCopyright
Two year-old ram with raised hindquarters and lowered head. Copious amount of foamy, whitish-mucous is observed coming from the the lungs. This is a very characteristic sign of sheep pulmonary adenomatosis.
TitleSymptoms
CaptionTwo year-old ram with raised hindquarters and lowered head. Copious amount of foamy, whitish-mucous is observed coming from the the lungs. This is a very characteristic sign of sheep pulmonary adenomatosis.
CopyrightM. de las Heras Guillamon
Two year-old ram with raised hindquarters and lowered head. Copious amount of foamy, whitish-mucous is observed coming from the the lungs. This is a very characteristic sign of sheep pulmonary adenomatosis.
SymptomsTwo year-old ram with raised hindquarters and lowered head. Copious amount of foamy, whitish-mucous is observed coming from the the lungs. This is a very characteristic sign of sheep pulmonary adenomatosis.M. de las Heras Guillamon
Lung from adult sheep showing classical sign of sheep pulmonary adenomatosis. Cranioventral and caudal areas of all lung lobules show extensive grey areas of tumour. Small tumour nodules of varying sizes can be seen in other areas.
TitleLung pathology
CaptionLung from adult sheep showing classical sign of sheep pulmonary adenomatosis. Cranioventral and caudal areas of all lung lobules show extensive grey areas of tumour. Small tumour nodules of varying sizes can be seen in other areas.
CopyrightM. de las Heras Guillamon
Lung from adult sheep showing classical sign of sheep pulmonary adenomatosis. Cranioventral and caudal areas of all lung lobules show extensive grey areas of tumour. Small tumour nodules of varying sizes can be seen in other areas.
Lung pathologyLung from adult sheep showing classical sign of sheep pulmonary adenomatosis. Cranioventral and caudal areas of all lung lobules show extensive grey areas of tumour. Small tumour nodules of varying sizes can be seen in other areas.M. de las Heras Guillamon
Sectioned lung from adult sheep showing classical signs of sheep pulmonary adenomatosis. Grey areas of tumour can be seen. Note copious amount of whitish-foamy fluid coming from the airways.
TitleLung pathology
CaptionSectioned lung from adult sheep showing classical signs of sheep pulmonary adenomatosis. Grey areas of tumour can be seen. Note copious amount of whitish-foamy fluid coming from the airways.
CopyrightM. de las Heras Guillamon
Sectioned lung from adult sheep showing classical signs of sheep pulmonary adenomatosis. Grey areas of tumour can be seen. Note copious amount of whitish-foamy fluid coming from the airways.
Lung pathologySectioned lung from adult sheep showing classical signs of sheep pulmonary adenomatosis. Grey areas of tumour can be seen. Note copious amount of whitish-foamy fluid coming from the airways.M. de las Heras Guillamon
Lung from adult sheep showing atypical form of sheep pulmonary adenomatosis. White, hard nodules of various sizes are distributed throughout the lung.
TitleLung pathology
CaptionLung from adult sheep showing atypical form of sheep pulmonary adenomatosis. White, hard nodules of various sizes are distributed throughout the lung.
CopyrightM. de las Heras Guillamon
Lung from adult sheep showing atypical form of sheep pulmonary adenomatosis. White, hard nodules of various sizes are distributed throughout the lung.
Lung pathologyLung from adult sheep showing atypical form of sheep pulmonary adenomatosis. White, hard nodules of various sizes are distributed throughout the lung.M. de las Heras Guillamon
Sectioned lung from adult sheep showing atypical form of sheep pulmonary adenomatosis. White scattered tumor nodules are distributed throughout the section. Note the foamy fluid is not evident in this anatomical form. (Note scale bar).
TitleLung pathology
CaptionSectioned lung from adult sheep showing atypical form of sheep pulmonary adenomatosis. White scattered tumor nodules are distributed throughout the section. Note the foamy fluid is not evident in this anatomical form. (Note scale bar).
CopyrightM. de las Heras Guillamon
Sectioned lung from adult sheep showing atypical form of sheep pulmonary adenomatosis. White scattered tumor nodules are distributed throughout the section. Note the foamy fluid is not evident in this anatomical form. (Note scale bar).
Lung pathologySectioned lung from adult sheep showing atypical form of sheep pulmonary adenomatosis. White scattered tumor nodules are distributed throughout the section. Note the foamy fluid is not evident in this anatomical form. (Note scale bar).M. de las Heras Guillamon
Histology of a sheep pulmonary adenomatosis tumour: adenomatomus transformation of the alveolar epthelium showing the characteristic papilliform growth of the type II alveolar cells. Papillary proliferations can seen in bronchioli. (Hematoxylin-Eosin).
TitleTumour histology
CaptionHistology of a sheep pulmonary adenomatosis tumour: adenomatomus transformation of the alveolar epthelium showing the characteristic papilliform growth of the type II alveolar cells. Papillary proliferations can seen in bronchioli. (Hematoxylin-Eosin).
CopyrightM. de las Heras Guillamon
Histology of a sheep pulmonary adenomatosis tumour: adenomatomus transformation of the alveolar epthelium showing the characteristic papilliform growth of the type II alveolar cells. Papillary proliferations can seen in bronchioli. (Hematoxylin-Eosin).
Tumour histologyHistology of a sheep pulmonary adenomatosis tumour: adenomatomus transformation of the alveolar epthelium showing the characteristic papilliform growth of the type II alveolar cells. Papillary proliferations can seen in bronchioli. (Hematoxylin-Eosin).M. de las Heras Guillamon

Identity

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Preferred Scientific Name

  • pulmonary adenomatosis

International Common Names

  • English: ovine pulmonary adenomatosis; ovine pulmonary carcinoma, adenomatosis in sheep and goats; pulmonary adenocarcinoma in sheep and goats; sheep pulmonary adenomatosis

Local Common Names

  • South Africa: jaagsiekte
  • USA: ovine pulmonary carcinoma

English acronym

  • OPA
  • OPC
  • SPA

Pathogen/s

Top of page jaagsiekte sheep retrovirus

Overview

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Sheep pulmonary adenomatosis (SPA) is a contagious disease of sheep produced by a tumour of type II alveolar and Clara cells in the lungs. The disease has been occasionally recorded naturally in goats and mouflon. SPA is also known as jaagsiekte and ovine pulmonary carcinoma. The term jaagsiekte was used in South Africa where the first cases were described and it is derived from two Afrikaner words: "jaag" drive and "siekte" = disease. The term ovine pulmonary carcinoma is preferred in the USA.

SPA is caused by a type B/D exogenous retrovirus, known as jaagsiekte sheep retrovirus (JSRV); its oncogenic mechanisms are not known. SPA is widely distributed throughout several continents, except Australia and New Zealand. No accurate figures about the economic importance of the disease are available, because there are no pre-clinical diagnostic tests. The prevalence of the disease has been evaluated only by post-mortem examination in diagnostic laboratories or of lungs at the abattoir. In spite of these difficulties, in some countries such as South Africa, Scotland (UK), Peru and Spain the disease appears to be widespread and causes a high number of deaths, mainly in young adult sheep. Meat production is generally affected.

Host Animals

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Animal nameContextLife stageSystem
Capra hircus (goats)
Ovis aries (sheep)

Hosts/Species Affected

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SPA is diagnosed mainly in young adult sheep but is (rarely) found in goats (Banerjee and Gupta, 1979, Sriraman et al., 1982, Metin et al., 1988), and wild mouflon, Ovis musimon (Nieddu et al., 1987). In countries where the disease is endemic, SPA may be more common in certain areas or breeds and also during the winter (Dungal et al., 1938; Tustin, 1969; Hunter and Munro, 1983). Any management condition that tends to keep animals housed for a long time promotes the spread of disease.

Systems Affected

Top of page respiratory diseases of small ruminants

Distribution

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The earliest known report of sheep pulmonary adenomatosis (SPA) comes from South Africa. In 1825, a letter by AP Aucamp reported a contagious respiratory disease known as "jaagziekte", which caused an elevated number of deaths with no recovery of affected animals. In the ensuing years, further reports confirmed the contagious and neoplastic nature of the disease and described other affected flocks, not only in South Africa, but also in several European countries (Tustin, 1969).

The history of the disease in Iceland deserves special mention. Nowadays this country is free of SPA but a very important epizootic causing a large number of deaths happened in the 1930s. The disease was imported from Germany in 1933 and introduced to an Icelandic farm called Deildartunga by a 1-year-old Karakul ram with no clinical signs of SPA. This ram was used to serve ewes and was kept in separate accommodation with one ewe and her lamb throughout the winter. The disease was noticed in the ram in the spring when the animals were released on the mountains. This ram did not return. In the following years, new cases appeared in the flock and in many others around the island, eventually killing between 50-80% of the animals in the affected flocks (Dungal et al., 1938). The high mortality probably was due to the particular sheep management system in Iceland. In this system, sheep are housed through the winter (1-4 months). At other times of the year, usually in September, sheep from different farms are concentrated at the heads of the valleys, where they spend several days before returning to their original farms. SPA was eradicated in 1952 following a very restrictive policy of sanitary control by killing all animals coming from flocks that showed any animal with clinical signs of the disease.

SPA has been recognised in many other countries throughout the world and, with the exception of Australia and New Zealand, is present in all continents with a varying degree of significance (see list of countries).

Distribution Table

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The distribution in this summary table is based on all the information available. When several references are cited, they may give conflicting information on the status. Further details may be available for individual references in the Distribution Table Details section which can be selected by going to Generate Report.

Last updated: 10 Jan 2020
Continent/Country/Region Distribution Last Reported Origin First Reported Invasive Reference Notes

Africa

AlgeriaAbsent, No presence record(s)OIE Handistatus (2005)
BotswanaAbsent, No presence record(s)OIE Handistatus (2005)
BurundiAbsent, No presence record(s)OIE Handistatus (2005)
Cabo VerdeAbsent, No presence record(s)OIE Handistatus (2005)
Central African RepublicAbsent, No presence record(s)OIE Handistatus (2005)
Congo, Democratic Republic of theAbsent, No presence record(s)OIE Handistatus (2005)
Côte d'IvoireAbsent, No presence record(s)OIE Handistatus (2005)
DjiboutiAbsent, No presence record(s)OIE Handistatus (2005)
EgyptAbsent, No presence record(s)OIE Handistatus (2005)
EritreaAbsent, No presence record(s)OIE Handistatus (2005)
EswatiniAbsent, No presence record(s)OIE Handistatus (2005)
EthiopiaAbsent, No presence record(s)OIE Handistatus (2005)
GhanaAbsent, No presence record(s)OIE Handistatus (2005)
GuineaAbsent, No presence record(s)OIE Handistatus (2005)
LesothoAbsent, No presence record(s)OIE (1998)
LibyaAbsent, No presence record(s)Alsenosy et al. (1986); OIE Handistatus (2005)
MadagascarAbsent, No presence record(s)OIE Handistatus (2005)
MauritiusAbsent, No presence record(s)OIE Handistatus (2005)
NamibiaPresent2003CABI (Undated a)
NigeriaAbsent, No presence record(s)OIE Handistatus (2005)
São Tomé and PríncipeAbsent, No presence record(s)OIE Handistatus (2005)
SeychellesAbsent, No presence record(s)OIE Handistatus (2005)
South AfricaPresentAucamp (1825); Tustin (1969); OIE Handistatus (2005)
SudanAbsent, No presence record(s)OIE Handistatus (2005)
TogoAbsent, No presence record(s)OIE (1998); OIE Handistatus (2005)
TunisiaAbsent, No presence record(s)Amara et al. (1994); OIE Handistatus (2005)
UgandaAbsent, No presence record(s)OIE Handistatus (2005)
ZimbabwePresent1994CABI (Undated)

Asia

BahrainAbsent, No presence record(s)OIE Handistatus (2005)
BhutanAbsent, No presence record(s)OIE Handistatus (2005)
BruneiAbsent, No presence record(s)OIE Handistatus (2005)
ChinaPresentCABI Data Mining (2001)
-XinjiangPresentDeng PuHui et al. (1996)
GeorgiaAbsent, No presence record(s)OIE Handistatus (2005)
Hong KongAbsent, No presence record(s)OIE Handistatus (2005)
IndiaAbsent, No presence record(s)Damodaran (1960); OIE Handistatus (2005)
-Andaman and Nicobar IslandsPresentSriraman et al. (1982)
-PunjabPresentBanerjee and Gupta (1979)
-RajasthanPresentDadhich and Sharma (1995)
-Uttar PradeshPresentRajya and Singh (1964); Sharma et al. (1975)
-West BengalPresentSarkar et al. (1988)
IndonesiaAbsent, No presence record(s)OIE Handistatus (2005)
IranAbsent, No presence record(s)Naghshineh and Sohrabi (1972); OIE Handistatus (2005)
IsraelPresentNobel (1958); Nobel et al. (1969); OIE Handistatus (2005)
JapanAbsent, No presence record(s)OIE Handistatus (2005)
JordanAbsent, No presence record(s)OIE Handistatus (2005)
KazakhstanAbsent, No presence record(s)OIE Handistatus (2005)
KuwaitAbsent, No presence record(s)OIE Handistatus (2005)
LebanonAbsent, No presence record(s)OIE Handistatus (2005)
Malaysia
-Peninsular MalaysiaPresent2003Shah et al. (1996)
-SabahAbsent, No presence record(s)OIE Handistatus (2005)
-SarawakAbsent, No presence record(s)OIE Handistatus (2005)
MongoliaAbsent, No presence record(s)OIE Handistatus (2005)
MyanmarAbsent, No presence record(s)OIE Handistatus (2005)
NepalAbsent, No presence record(s)OIE Handistatus (2005)
North KoreaAbsent, No presence record(s)OIE Handistatus (2005)
OmanAbsent, No presence record(s)OIE Handistatus (2005)
PhilippinesAbsent, No presence record(s)OIE Handistatus (2005)
Saudi ArabiaAbsent, No presence record(s)OIE Handistatus (2005)
SingaporeAbsent, No presence record(s)OIE Handistatus (2005)
South KoreaAbsent, No presence record(s)OIE Handistatus (2005)
Sri LankaAbsent, No presence record(s)OIE Handistatus (2005)
SyriaAbsent, No presence record(s)OIE Handistatus (2005)
TaiwanAbsent, No presence record(s)OIE Handistatus (2005)
ThailandAbsent, No presence record(s)OIE Handistatus (2005)
TurkmenistanAbsent, No presence record(s)OIE Handistatus (2005)
UzbekistanAbsent, No presence record(s)OIE Handistatus (2005)
VietnamAbsent, No presence record(s)OIE Handistatus (2005)

Europe

AndorraPresentOIE Handistatus (2005)CAB Abstracts Data Mining
AustriaAbsent, No presence record(s)OIE Handistatus (2005)
BelarusAbsent, No presence record(s)OIE Handistatus (2005)
Bosnia and HerzegovinaAbsent, No presence record(s)OIE Handistatus (2005)
BulgariaAbsent, No presence record(s)ENCHEV et al. (1958); OIE Handistatus (2005)
CroatiaAbsent, No presence record(s)OIE Handistatus (2005)
CyprusPresent1993Toumazos (1989)
CzechiaPresent1995Seidl (1990); CABI (Undated)
DenmarkPresent2000CABI (Undated a)
EstoniaAbsent, No presence record(s)OIE Handistatus (2005)
FinlandAbsent, No presence record(s)OIE Handistatus (2005)
FrancePresentAynaud (1926); Moraillon and Yalcin (1967); OIE Handistatus (2005)
GermanyPresentJakob and Krauze (1965); Geisel (1975); OIE Handistatus (2005); CABI (Undated)CAB Abstracts Data Mining
GreecePresent2003Christodoulous and Tarlatis (1952); Stefanou et al. (1975)
HungaryPresent1970Glávits et al. (1996)
IrelandPresentBassett and Sheehan (1989); OIE Handistatus (2005)
Isle of ManAbsent, No presence record(s)OIE Handistatus (2005)
JerseyAbsent, No presence record(s)OIE Handistatus (2005)
LatviaAbsent, No presence record(s)OIE Handistatus (2005)
LiechtensteinAbsent, No presence record(s)OIE Handistatus (2005)
LithuaniaAbsent, No presence record(s)OIE Handistatus (2005)
LuxembourgAbsent, No presence record(s)OIE Handistatus (2005)
MaltaAbsent, No presence record(s)OIE Handistatus (2005)
MoldovaAbsent, No presence record(s)OIE Handistatus (2005)
North MacedoniaAbsent, No presence record(s)OIE Handistatus (2005)
NorwayAbsent, No presence record(s)Krogsrud et al. (1996); OIE Handistatus (2005)
PolandAbsent, No presence record(s)Kopczewski et al. (1986); OIE Handistatus (2005)
PortugalPresentMadeira (1949); OIE Handistatus (2005)
RomaniaAbsent, No presence record(s)Adamesteanu et al. (1969); OIE Handistatus (2005)
RussiaPresentOIE Handistatus (2005)
-Central RussiaPresentKostenko (1964)
-Southern RussiaPresentMitrofanov (1963)
Serbia and MontenegroAbsent, No presence record(s)Cvjetanovic and Martinic (1962); Prašović et al. (1991); OIE Handistatus (2005)
SlovakiaAbsent, No presence record(s)OIE Handistatus (2005)
SloveniaAbsent, No presence record(s)OIE Handistatus (2005)
SwedenAbsent, No presence record(s)Nilsson (1984); OIE Handistatus (2005)
SwitzerlandPresentPusterla et al. (1995); OIE Handistatus (2005)
United KingdomPresentMcFadyean (1938); Hunter and Munro (1983); Pritchard and Done (1990); OIE Handistatus (2005)

North America

BarbadosAbsent, No presence record(s)OIE Handistatus (2005)
BelizeAbsent, No presence record(s)OIE Handistatus (2005)
BermudaAbsent, No presence record(s)OIE Handistatus (2005)
British Virgin IslandsAbsent, No presence record(s)OIE Handistatus (2005)
CanadaPresentStevenson et al. (1980); OIE Handistatus (2005)
Cayman IslandsAbsent, No presence record(s)OIE Handistatus (2005)
Costa RicaAbsent, No presence record(s)OIE Handistatus (2005)
CubaAbsent, No presence record(s)OIE Handistatus (2005)
CuraçaoAbsent, No presence record(s)OIE Handistatus (2005)
DominicaAbsent, No presence record(s)OIE Handistatus (2005)
Dominican RepublicAbsent, No presence record(s)OIE Handistatus (2005)
El SalvadorAbsent, No presence record(s)OIE Handistatus (2005)
GuadeloupeAbsent, No presence record(s)OIE Handistatus (2005)
GuatemalaAbsent, No presence record(s)OIE Handistatus (2005)
HaitiAbsent, No presence record(s)OIE Handistatus (2005)
HondurasAbsent, No presence record(s)OIE Handistatus (2005)
JamaicaAbsent, No presence record(s)OIE Handistatus (2005)
MexicoAbsent, No presence record(s)Equiluz and De Aluja (1981); OIE Handistatus (2005)
NicaraguaAbsent, No presence record(s)OIE Handistatus (2005)
PanamaAbsent, No presence record(s)OIE Handistatus (2005)
Saint Vincent and the GrenadinesAbsent, No presence record(s)OIE Handistatus (2005)
Trinidad and TobagoAbsent, No presence record(s)OIE Handistatus (2005)
United StatesPresentMarsh (1966); Cutlip and Young (1982); OIE Handistatus (2005)
-ColoradoPresentCutlip and Young (1982)
-MinnesotaPresentMarsh (1966); Cutlip and Young (1982)
-WyomingPresentCutlip and Young (1982)

Oceania

AustraliaAbsent, No presence record(s)OIE Handistatus (2005)
French PolynesiaAbsent, No presence record(s)OIE Handistatus (2005)
New CaledoniaAbsent, No presence record(s)OIE Handistatus (2005)
New ZealandAbsent, No presence record(s)OIE Handistatus (2005)
SamoaAbsent, No presence record(s)OIE Handistatus (2005)
VanuatuAbsent, No presence record(s)OIE Handistatus (2005)

South America

ArgentinaPresentGea and González Quintana (1992); OIE Handistatus (2005)
Brazil
-Mato Grosso do SulPresentDrimeier et al. (1998)
ChilePresentSchultz et al. (1965); OIE Handistatus (2005)
ColombiaAbsent, No presence record(s)OIE (1998); OIE Handistatus (2005)
EcuadorAbsent, No presence record(s)OIE Handistatus (2005)
Falkland IslandsAbsent, No presence record(s)OIE Handistatus (2005)
French GuianaAbsent, No presence record(s)OIE Handistatus (2005)
GuyanaAbsent, No presence record(s)OIE Handistatus (2005)
ParaguayAbsent, No presence record(s)OIE Handistatus (2005)
PeruPresentCuba-Caparo (1945); Cuba-Caparo et al. (1961); Snyder et al. (1983); Ellis et al. (1993); OIE Handistatus (2005)
VenezuelaAbsent, No presence record(s)OIE Handistatus (2005)

Pathology

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Post-mortem examination of the sheep affected by SPA shows that lesions are confined mainly to the lungs. They are considerably enlarged and heavier than normal due to infiltration by areas of tumour which may vary from small discrete nodules, measuring only 0.5-2 cm, to extensive tumours involving the entire ventral half of the diaphragmatic and other lobes. Usually tumour tissue is present in both lungs although the extent on either side does vary. The lesions can be segregated into two general types:


Classical SPA


Tumours are solid, grey or light purple with a shiny translucent sheen and often separated from adjacent normal lung by a narrow emphysematous zone. The presence of frothy white fluid in the respiratory passages is a prominent feature and is obvious even in lesions as small as a few millimetres. In advanced cases, this fluid flows out of the trachea when it is cut or pendant. Histological examination of SPA lesions shows areas of lung where cuboidal or columnar cells replace the normal thin alveolar cells. Sometimes these abnormal cells form papilliform growths that project into the alveoli. Intrabronchiolar proliferation also may be present. The histological picture is classified as a bronchioloalveolar cell carcinoma. A third type of change consists of nodules of loose connective tissue in a mucopolysaccharide substance. Accumulations of large macrophage cells occur in the lung tissue around the tumours (Wandera, 1971; Sharp and Angus, 1990).


Atypical SPA


Tumours comprise solitary or aggregated hard white nodules, which have a dry cut surface and show clear demarcation from surrounding tissues. The presence of excess fluid is not a prominent feature. The histological appearance of these tumours is essentially the same as classical SPA but with an exaggerated inflammatory response (mostly lymphocytes and plasma cells) and fibrosis (De las Heras et al.,1992; Garcia Goti et al., 2000).

Pleurisy may be evident over the surface of the tumour and in some cases abscesses or gangrenous tissue are present in the adenomatous tissue.

Adult sheep, that on post-mortem examination appear to have died from acute pasteurellosis should have their lungs examined carefully, as lesions of SPA may be masked by the acute reaction to the Pasteurellae.

The tumour rarely metastasises beyond the mediastinal lymph nodes but extrathoracic tumour metastases can be found in some cases (Nobel et al., 1969).

Ultrastructural studies have shown that the cells forming the alveolar lesion are type II alveolar cells and those in the bronchiolar tumours, the cells of Clara (Nisbet et al., 1971; Perk et al., 1971).

Diagnosis

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Clinical detection of a case of classical SPA should be based on the presence, in a single mature sheep of an afebrile wasting disease, with marked respiratory signs. A useful aid to diagnosis is to raise the hindquarters and lower the head of the sheep, which causes mucoid fluid, sometimes copious in amount, to run from the nostrils. This is the key clinical sign to differentiate SPA from other sheep lung diseases that can show respiratory distress but never the emission of such amount and type of fluid. Large tumours are unmistakable in appearance at necropsy but confirmatory histology may be necessary where the amount of adenomatous tissue is small or secondary bacterial pneumonia has developed. Where tumours are not obvious, at least 1-2 samples for histological examination should be taken from each lobe. The transformed epithelial cells are the major sites of virus replication and JSRV antigens can be revealed by immunohistochemical techniques (Palmarini et al., 1995).

At present, there are no laboratory tests to support a clinical diagnosis of SPA in the live animal. JSRV has been associated exclusively with both classical and atypical forms of SPA but antibodies to this virus have not been detected in the sera of affected sheep, even with highly sensitive assays such as immunoblotting (Ortín et al., 1998).

Sequencing of JSRV and SERVs has led to the development of PCR that can detect the exogenous virus in a background of genomic DNA and endogenous sequences (Palmarini et al., 1997). Using this sensitive procedure, JSRV has been detected in the blood of unaffected in-contact sheep from flocks with SPA, as well as experimentally infected lambs. This finding suggests that infected animals can be identified during the pre-clinical stages and may offer a new way to diagnose SPA.

List of Symptoms/Signs

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SignLife StagesType
General Signs / Exercise intolerance, tires easily Sheep & Goats:Hogget,Sheep & Goats:Gimmer,Sheep & Goats:Mature female,Sheep & Goats:Breeding male Sign
General Signs / Generalized weakness, paresis, paralysis Sign
General Signs / Reluctant to move, refusal to move Sign
General Signs / Sudden death, found dead Sign
General Signs / Underweight, poor condition, thin, emaciated, unthriftiness, ill thrift Sheep & Goats:Hogget,Sheep & Goats:Gimmer,Sheep & Goats:Mature female,Sheep & Goats:Breeding male Diagnosis
General Signs / Weight loss Sheep & Goats:Hogget,Sheep & Goats:Gimmer,Sheep & Goats:Mature female,Sheep & Goats:Breeding male Diagnosis
Respiratory Signs / Abnormal breathing sounds of the upper airway, airflow obstruction, stertor, snoring Sign
Respiratory Signs / Abnormal lung or pleural sounds, rales, crackles, wheezes, friction rubs Sheep & Goats:Hogget,Sheep & Goats:Gimmer,Sheep & Goats:Mature female,Sheep & Goats:Breeding male Sign
Respiratory Signs / Coughing, coughs Sign
Respiratory Signs / Dull areas on percussion of chest, thorax Sign
Respiratory Signs / Dyspnea, difficult, open mouth breathing, grunt, gasping Sheep & Goats:Hogget,Sheep & Goats:Gimmer,Sheep & Goats:Mature female,Sheep & Goats:Breeding male Sign
Respiratory Signs / Increased respiratory rate, polypnea, tachypnea, hyperpnea Sheep & Goats:Hogget,Sheep & Goats:Gimmer,Sheep & Goats:Mature female,Sheep & Goats:Breeding male Sign
Respiratory Signs / Mucoid nasal discharge, serous, watery Sheep & Goats:Hogget,Sheep & Goats:Gimmer,Sheep & Goats:Mature female,Sheep & Goats:Breeding male Diagnosis
Respiratory Signs / Purulent nasal discharge Sign

Disease Course

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In naturally infected sheep, the incubation period appears to be long, so that the disease is not usually seen until sheep are about 2-4 years old. However, tumours have been seen exceptionally in lambs as young as 2 months and in a sheep as old as 11 years of age (Hunter and Munro, 1983; Sharp and Angus, 1990). Clinical signs of the disease only appear when the tumours are sufficiently large to interfere with normal lung function resulting in respiratory embarrassment, which is most obvious following exercise. Abattoir studies have revealed small SPA lesions in clinically normal animals (De las Heras et al., 1992). Experimentally, tumour formation occurs 5-12 months after the intra-tracheal inoculation of tumour tissue or lung fluid extracts containing JRSV into lambs several months old (Wandera, 1971; Martin et al., 1976; Herring et al., 1983). However, when neonatal lambs are inoculated with these extracts or virions from the infectious molecular clone, the tumours can be reproduced in several weeks (Sharp et al., 1983, Palmarini et al., 1999).

The mechanisms of oncogenesis by JSRV are unknown and can only be speculated. The natural course of the disease suggests a very long incubation period, which would be compatible with oncogenenesis by retroviruses that lack oncogenes and induce tumours by insertional mutagenesis. This hypothesis is supported by the absence of recognisable oncogenes in the sequence of JSRV (York et al., 1992). However, the rapid induction of tumour in neonatal lambs is more characteristic of the tumours induced by acute transforming retroviruses that encode oncogenes. Other factors, such as viral dose and the age of the inoculated lamb, may be important and may account for the different types of disease response (Palmarini et al., 1997). JSRV establishes a disseminated infection in SPA-affected sheep (Palmarini et al., 1996b) and can be detected in lymphoid tissue before the onset of neoplasia (Holland et al., 1999). The dissemination of the virus is less intense in atypical SPA than in classical SPA (see types of lesions of SPA described in Pathology section) and in this form the number of tumour infiltrating cells and fibrosis is more intense, suggesting that in some animals the response to the virus is different (Garcia Goti et al., 2000). Although little is know about this area, the interaction between the JSRV and host immune system may be important in the pathogenesis of the disease.

Epidemiology

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SPA has been recognised for many years to be naturally and experimentally transmissible by the respiratory route. It is probable that an infected sheep, even before it develops obvious respiratory signs, excretes virus-containing droplets as it breathes. Later, as the disease progresses, it will discharge quantities of infective respiratory fluid, especially during feeding when the head is lowered. This causes the sheep to snuffle and doubtless creates an aerosol of infected droplets. Close confinement of a flock obviously increases the probability of transmission so that housing with trough feeding and watering may allow the infection to spread.

SPA is generally introduced into flocks by the acquisition of infected sheep. Losses from classical SPA can be high when the disease is first introduced. During the epidemic of SPA in Iceland the estimated time from the introduction of the disease and the appearance of the first clinical cases in other sheep was between 6 and 8 months (Dungal et al., 1938). All of the existing epidemiological information has been based on clinical diagnosis and pathology, and the extent of infection by jaagsiekte retrovirus (JSRV) in affected flocks is unknown.

Impact: Economic

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There are no data available in terms of the real cost of SPA but there is some information about the percentage of animals that have died of the disease and of animals that show SPA-associated lesions at slaughterhouses. In endemic areas such as South Africa or Scotland the percentage of sheep killed by SPA is about 2-4% annually (Tustin, 1969; Hunter and Munro, 1983). However, in countries or farms where the disease has been recently introduced, the mortality, depending on management conditions, could reach 30-80% in the first two years (Dungal et al., 1938; Shirlaw, 1959; Enchev et al., 1958). Where the prevalence has been estimated as a proportion of the number of sheep slaughtered, the percentages can be as low as 0.1-0.2% in Chile or Germany (Schultz et al., 1965), 0.5-0.6% in India (Banerjee and Gupta, 1979), 0.6-1.7% in Perú (Ellis et al., 1993), 0.4-1.6% in Spain (De las Heras et al., 1992) or 0.7% in Italy (Cerretto and Deiana, 1967).

Zoonoses and Food Safety

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A protein related antigenically to JSRV has been demonstrated in approximately 30% of three forms of human primary pulmonary carcinoma and not in other tumours or diseases (De las Heras et al., 1997). This observation supports the view that the antigen in the human tumours may be a retrovirus protein and that a retrovirus may be associated with the neoplastic process in some tumours or represent reactivation/upregulation of an endogenous retrovirus. Although there is no epidemiological evidence to implicate JSRV as a cause of disease in man, recent demonstration of a receptor for JSRV on human cells warrants a cautious reappraisal of any potential zoonotic role.

Disease Treatment

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No method of treatment is recognised or advised. Once the disease is detected there is no possibility of cure. Antimicrobial therapy only reduces the intensity of clinical signs for a short time.

Prevention and Control

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Control should be based on regular inspection of adult sheep in affected flocks. Any animal showing weight loss or signs of respiratory disease should be isolated and veterinary advice sought. Prompt culling of any suspicious animal is advisable, as well as the offspring of affected ewes, which frequently develop SPA. While these methods are unlikely to eradicate SPA from a flock in which the disease is endemic, reduction in the prevalence of infection may be obtained.

Embryo transfer has been reported as one way to obtain animals free of SPA, based on clinical and pathological evidence (Parker et al., 1998). It would be worthwhile to re-evaluate this approach with the more sensitive PCR techniques to confirm that the offspring were free of JSRV infection.

References

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Adamesteanu C; Rusu M; Baba I; Vesa S, 1969. Pulmonary adenomatosis in sheep in Romania. Revista de zootehnie medicina si veterinara, 19:54-60.

Alsenosy AM; Ahmed SS; Arnautovic I; Dzuvic A; Ivetic V, 1986. First confirmation of ovine pulmonary adenomatosis (jaagsiekte) in two indigenous Barbary ewes in Libya. Veterinaria, Yugoslavia, 35(2):169-178; 54 ref.

Amara A; Jemli MH; Boutouria M; Chetoui C, 1994. First case of adenomatosis in a ewe in Tunisia. Revue d'élevage et de Médecine Vétérinaire des Pays Tropicaux, 47(1):33-34; 8 ref.

Aucamp VP, 1825. Cape Archives, GR 12/4.

Aynaud M, 1926. Origin verminouse du cancer pulmonaire de la brebis. Comptes rendus des scances de la Societe de Biologie, 95:1540-1542.

Bai J; Zhu RY; Stedman K; Cousens C; Carlson J; Sharp JM; DeMartini JC, 1996. Unique long terminal repeat U3 sequences distinguish exogenous jaagsiekte sheep retroviruses associated with ovine pulmonary carcinoma from endogenous loci in the sheep genome. Journal of Virology, 70(5):3159-3168; 45 ref.

Banerjee M; Gupta PP, 1979. Note on Maedi and Jaagziekte in sheep and goats in Ludbiana area of Punjab. Indian Journal of Animal Science, 49:1102-1105.

Basset B; Sheehan P, 1989. Outbreak of sheep pulmonary adenomatosis in the Irish Republic. Veterinary Record, 124:46-47.

Bouljihad M; Drommer W; Leipold HW, 1996. Pathologic and ultrastructural findings in sheep in Morocco with naturally occurring jaagsiekte (sheep pulmonary adenomatosis). Small Ruminant Research, 19(3):275-280; 28 ref.

Carrara O; Gasparini G, 1959. Atti della Societa Italiana di Scence Veterinaria, 13:450.

Cerretto F; Deiana L, 1967. Adenomatosi polmonare enzootica degli ovini (jaagsiekte) in Sardegna. Atti della Societa Italiana di Scence Veterinaria, 21:606-611.

Christodoulous T; Tarlatis K, 1952. Chronic glandular pneumonia in the sheep (jaagsiekte). Deltion tes Hellenikes Kten. Hetaireias, 2:199-208.

Cuba-Caparo A, 1945. Boletin de la Escuela Nacional de Ciencias Veterinarias, 1:27.

Cuba-Caparo A; de la Vega E; Copaira M, 1961. Pulmonary adenomatosis of sheep metastasizing bronchiolar tumours. American Journal of Veterinary Research, 22:673-682.

Cutlip RC; Young S, 1982. Sheep pulmonary adenomatosis (Jaagsiekte) in the United States. American Journal of Veterinary Research, 43:2108-2113.

Cvjetanovic J; Martinic M, 1962. Epizooticna plucna adenomatoza 0vaca pao (jaagziekte) n Jugoslaviji. Veterinarski Archiv, 32:77-92.

Dadhich H; Sharma GD, 1995. A note on Jaagsiekte and maedi in goats from Rajasthan. Indian Journal of Veterinary Pathology, 19(2):140-141; 5 ref.

Damodaran S, 1960. Ovine pulmonary adenomatosis (Jaagsiekte). Indian Veterinary Journal, 37:127-138.

De las Heras M; Calafat JJ; Jaime JM; García de Jalon JA; Ferrer LM; García Goti M; Minguijon E, 1992. Sheep pulmonary adenomatasis (jaagsiekte) in slaughtered sheep. Variation in pathological characteristics. Medicina Veterinaria, 9:52-52.

De las Heras M; Palamarini M; Larsson E; Haselton P; Wagner M; Minguijón E; Egan J; Dewar P; Ortín A; Gimenez Más JA; Gonzalez L; Dalziel R; Sharp JM, 1997. Human bronhioloalveolar carcinoma contains a protein related antigenically to jaagsiekte sheep retrovirus capsid. Meeting on Retroviruses. New York, USA: Cold Spring Harbour.

Deng PuHui; Hian ZiJian; Bai HuiMin, 1996. Retrospective investigation of pulmonary adenomatosis of sheep in Xinjiang. Chinese Journal of Veterinary Medicine, 22(1):3-5; 20 ref.

Drimeier D; Moojen V; Faccini GS; de Oliveira RT, 1998. Ciencia Rural, 28:147-150.

Dualde D, 1963. Estudio general y causistico de la adenomatosis pulmonar ovina en España. Proceedings of the 17th World Veterinary Congress, 1:347-355.

Dungal N; Gislason G; Taylor EL, 1938. Epizootic adenomatosis in the lung of sheep-comparisons with jaagsiekte, verminous pneumonia and progressive pneumonia. Journal of Comparative Pathology and Therapeutics, 51:46-68.

Eber A, 1899. Z. Tiermed, 3:161.

Ellis JA; Chavera AEV; DeMartini JC, 1993. Disease conditions in slaughtered sheep from small holder flocks in Peru. Small Ruminant Research, 10(3):243-250; 11 ref.

Enchev S; Tomov T; Ivano I, 1958. Pulmonary adenomatosis of sheep in Bulgaria. Izvestia Institute Patologiya na Zhivotnite, Sofia, 6:365-367.

Equiluz C; De Aluja AS, 1981. Neumonía intersticial progresiva (Maedi) y adenomatosis pulmonar en vísceras de óvidos decomisados. Vetrinaria México, 12:235-237.

García-Goti M; González L; Cousens C; Cortabarría N; Extramiana AB; Minguijón E; Ortín A; Heras Mde las; Sharp JM, 2000. Sheep pulmonary adenomatosis: characterization of two pathological forms associated with Jaagsiekte retrovirus. Journal of Comparative Pathology, 122(1):55-65; 36 ref.

Gea GSde; González Quintana H, 1992. Pulmonary diseases of sheep in Argentina. Veterinaria Argentina, 8(83):190, 192-193; 10 ref.

Geisel O, 1975. Zur Morphologie der spontanen Lungadenomatose des Schafes. Zentralblat für Veterinä Medizin. B. 22:535-543.

Glávits R; Molnár T; Pálfi V; Tenk M, 1996. Pulmonary adenomatosis in a goat. Magyar állatorvosok Lapja, 51(10):582-584; 13 ref.

González L; Juste RA; Cuervo LA; Idigoras I; Saez de Ocariz C, 1993. Pathological and epidemiological aspects of the coexistence of maedi-visna and sheep pulmonary adenomatosis. Research in Veterinary Science, 54(2):140-146; 26 ref.

Halouzka R; Celer V, 1993. Pathology and differential diagnosis of visna maedi disease. Veterinární Medicína, 38(12):705-721; 20 ref.

Hecht SJ; Sharp JM; Demartini JC, 1996. Retroviral aetiopathogenesis of ovine pulmonary carcinoma: a critical appraisal. British Veterinary Journal, 152(4):395-409; 4 pp. of ref.

Herring AJ; Sharp JM; Scott FMM; Angus KW, 1983. Further evidence for a retrovirus as the aetiological agent of sheep pulmonary adenomatosis (Jaagsiekte). Veterinary Microbiology, 8:237-249.

Holland MJ; Palmarini M; Garcia-Goti M; Gonzalez L; McKendrick I; Heras Mde las; Sharp JM, 1999. Jaagsiekte retrovirus is widely distributed both in T and B lymphocytes and in mononuclear phagocytes of sheep with naturally and experimentally acquired pulmonary adenomatosis. Journal of Virology, 73(5):4004-4008; 36 ref.

Houwers DJ; Terpstra C, 1984. Sheep pulmonary adenomatosis. [Correspondence]. Veterinary Record, 114(1):23; 2 ref.

Hunter AR; Munro R, 1983. The diagnosis, occurrence and distribution of sheep pulmonary adenomatosis in Scotland 1975 to 1981. British Veterinary Journal, 139:153-164.

Jakob W; Krauze H, 1965. Zum Auftreten der enzootischen lung adenomatose in Schafbestanden- Moneastschef fur Veterinarmedizin, 60:217-223.

Kiran MM, 1993. Pathological studies on ovine pulmonary adenomatosis. Veteriner Fakültesi Dergisi, Selcuk üniversitesi, 9(1):41-45; 15 ref.

Kopczewski A; Salwa A; Baczynski Z, 1986. Structural and seasonal losses in Pomeranian and Merino sheep from adenomatosis and visna-maedi. Medycyna Weterynaryjna, 42(11/12):673-677; 21 ref.

Kostenko YG, 1964. Adenomatosis of sheep. Veterinariya Moscow, 41:34-36.

Krogsrud J; Larsen HJS; Rimstad E, 1996. Visna maedi and pulmonary adenomatosis. Norsk Veterinærtidsskrift, 108(10):729-736; 12 ref.

Madeira AC, 1949. Adenocarcinoma em focos multiples do pulmao em um ovino. Revista de medicina veterinaria, Lisboa, 44:95-100.

Marsh H, 1966. Progressive pneumonia of sheep in the United States and its relation to disease of the Jaagsiekte complex. In: Sereril L, ed. Proceedings Third Quadrennial Conference on Cancer: Lung tumours in animals, Perugia, Italy, 285-294.

Martin WB; Scott FFM; Sharp JM; Angus KW; Norval M, 1976. Experimental production of sheep pulmonary adenomatosis (Jaagsiekte), Nature 264:183-185.

McFadyean J, 1938. Jaagsiekte. Journal of Comparative Pathology and Therapeutics, 51:78-84.

Metin N; özer H; ciftci MK, 1988. Pathological studies on pneumonia in goats in Elazig. Veteriner Fakültesi Dergisi, Selcuk üniversitesi, 4(1):231-237; 21 ref.

Mitrofanov VM, 1963. Histogenesis of pulmonary adenomatosis in sheep. Arkhiv Patologi, 25:46-51.

Moraillon P; Yalcin N, 1967. Adenomatose pulmonaire des ovins en France. Proceedings of the 18th World Veterinary Congress, 1:323-324.

Naghshineh R; Sohrabi I, 1972. Pulmonary adenomatosis in Iran. Journal of the Veterinary Faculty University of Teheran, 29.

Nieddu AM; Coda S; Loi P, 1987. L´adenomatose polmonare del muflone. Proc. SISVET, 41:892-894.

Nilsson N-G, 1984. Tumours of slaughter animals in Sweden. Svensk Veterinärtidning, 36(6):295-297; 14 ref.

Nisbet DI; Mackay JMK; Smith W; Gray EW, 1971. Ultrastructure of sheep pulmonary adenomatosis (jaagsiekte). Journal of Pathology, 103:157-162.

Nobel TA, 1958. Pulmonary adenomatosis (jaagsiekte) in sheep with special reference to its occurrence in Israel . Refuah Veterinarith, 15:101-198.

Nobel TA; Neumann F; Klopper U, 1969. Histological patterns of the metastases in pulmonary adenomatosis of sheep (jaagsietke). Journal of Comparative Pathology, 79:537-540.

OIE Handistatus, 2002. World Animal Health Publication and Handistatus II (dataset for 2001). Paris, France: Office International des Epizooties.

OIE Handistatus, 2003. World Animal Health Publication and Handistatus II (dataset for 2002). Paris, France: Office International des Epizooties.

OIE Handistatus, 2004. World Animal Health Publication and Handistatus II (data set for 2003). Paris, France: Office International des Epizooties.

OIE Handistatus, 2005. World Animal Health Publication and Handistatus II (data set for 2004). Paris, France: Office International des Epizooties.

OIE, 1998. World Animal Health in 1997. Office International des Epizooties, Paris, France, Vol. 1-2.

Ortín A; Minguijón E; Dewar P; García M; Ferrer LM; Palmarini M; Gonzalez L; Sharp JM; Heras Mde las, 1998. Lack of a specific immune response against a recombinant capsid protein of Jaagsiekte sheep retrovirus in sheep and goats naturally affected by enzootic nasal tumour or sheep pulmonary adenomatosis. Veterinary Immunology and Immunopathology, 61(2/4):229-237; 19 ref.

Palmarini M; Cousens C; Dalziel RG; Bai J; Stedman K; DeMartini JC; Sharp JM, 1996. The exogenous form of jaagsiekte retrovirus is specifically associated with a contagious lung cancer of sheep. Journal of Virology, 70(3):1618-1623; 43 ref.

Palmarini M; Dewar P; Heras Mde las; Inglis NF; Dalziel RG; Sharp JM, 1995. Epithelial tumour cells in the lungs of sheep with pulmonary adenomatosis are major sites of replication for Jaagsiekte retrovirus. Journal of General Virology, 76(11):2731-2737; 42 ref.

Palmarini M; Fan Hung; Sharp JM, 1997. Sheep pulmonary adenomatosis: a unique model of retrovirus-associated lung cancer. Trends in Microbiology, 5(12):478-483; 47 ref.

Palmarini M; Holland MJ; Cousens C; Dalziel RG; Sharp JM, 1996. Jaagsiekte retrovirus establishes a disseminated infection of the lymphoid tissues of sheep affected by pulmonary adenomatosis. Journal of General Virology, 77(12):2991-2998; 46 ref.

Palmarini M; Sharp JM; Heras Mde las; Fan Hung, 1999. Jaagsiekte sheep retrovirus is necessary and sufficient to induce a contagious lung cancer in sheep. Journal of Virology, 73(8):6964-6972; 49 ref.

Parker BNJ; Wrathall AE; Saunders RW; Dawson M; Done SH; Francis PG; Dexter I; Bradley R, 1998. Prevention of transmission of sheep pulmonary adenomatosis by embryo transfer. Veterinary Record, 142(25):687-689; 15 ref.

Payne A-L; Verwoerd DW; Garnett HM, 1983. The morphology and morphogenesis of jaagsiekte retrovirus (JSRV). Onderstepoort Journal of Veterinary Research, 50(4):317-322; 23 ref.

Perk K; Hod I; Nobel TA, 1971. Pulmonary adenomatosis of Sheep (Jaagsiekte). I. Ultrastructure of the tumour. Journal of Natural Cancer Institute, 46:525-537.

Prasovic S; Ivetic V; Sudaric F, 1991. Pulmonary adenomatosis in a Pramenka sheep. Veterinaria (Sarajevo), 40(1-2):225-230; 20 ref.

Pritchard GC; Done SH, 1990. Concurrent maedi-visna virus infection and pulmonary adenomatosis in a commercial breeding flock in East Anglia. Veterinary Record, 127(8):197-200; 11 ref.

Pusterla N; Braun U; Grest P; Ossent P, 1995. Pulmonary adenomatosis in a sheep. Diagnosis by lung biopsy under ultrasonic guidance. Tierärztliche Umschau, 50(5):340-343; 11 ref.

Rajya BS; Singh CM, 1964. The pathology of pneumonia and associated respiratory disease of sheep and goats in India. I. Ocurrence of jaagziekte and Maedi in sheep and goats in India. American Journal of Veterinary Research, 25:61-67.

Romboli B, 1959. Pneumopatie displastiche progressive (jaagziekte-simile) nelle pecore macellate in Toscana. Universika di Pisa. Annali della Facolta di Medicina Veterinaria, 12:50-96.

Romboli B; Botti L, 1957. Atti della Societa Italiana di Scence Veterinaria. 10:416.

Santiago Luque JM, 1963. Nuevos datos anatomo e histopatologicos sobre la adenomatosis pulmonar ovina. 17th World Veterinary Congress, Hannover, 357-360.

Sarkar CR; Chakrabaril A; Deb S; Nandy SN, 1988. Pulmonary adenomatosis (jaagsiekte) of sheep in West Bengal. Indian Veterinary Journal, 65(4):353-354; 11 ref.

Schultz L; Somoza A; Weiland F, 1965. Zum auftreten und zum tumour charakter der enzootischen lungadenomatose des schafes vergleichende unter suchungenin Chile und in der Bundesrepublik Deutschland. Deutsche tieraertliche Wochenschrift, 72:458-461.

Scott FMM; Sharp JM; Angus KW; Gray EW, 1984. Infection of specific-pathogen free lambs with a herpesvirus isolated from pulmonary adenomatosis. Archives of Virology, 80(2/3):147-162; 33 ref.

Seidl K, 1990. Pulmonary adenomatosis of sheep. Veterinárství, 40(12):539.

Shah AMA; Jasni S; Zamri-Saad M, 1996. More cases of sheep pulmonary adenomatosis [in Malaysia]. Jurnal Veterinar Malaysia, 8(2):69-71; [9 ref].

Sharma DN; Rajya BS; Dwivedi JN, 1975. Metastasizing pulmonary adenomatosis (Jaagziekte) in sheep and goats. Patho-anatomical studies. Indian Journal of Animal Science, 45:363-370.

Sharp JM; Angus KW, 1990. Sheep pulmonary adenomatosis: clinical, pathological and epidemiological aspects. Maedi-visna and related diseases., 157-175; 33 ref.

Sharp JM; Angus KW; Gray EW; Scott FMM, 1983. Rapid transmission of sheep pulmonary adenomatosis (jaagsiekte) in young lambs. Archives of Virology, 78(1/2):89-95; 10 ref.

Sharp JM; Herring AJ, 1983. Sheep pulmonary adenomatosis: demonstration of a protein which cross-reacts with the major core proteins of Mason-Pfizer monkey virus and mouse mammary tumour virus. Journal of General Virology, 64(10):2323-2327; 20 ref.

Shirlaw JF, 1959. Studies on Jaagsiekte in Kenya. Bulletin of Epizootic Diseases in Africa, 7:287-302.

Snyder SP; DeMartini JC; Ameghino E; Celetti E, 1983. Coexistence of pulmonary adenomatosis and progressive pneumonia in sheep in the central sierra of Peru. American Journal of Veterinary Research, 44:1334-1338.

Sriraman PK; Rama Rao P; Gopal Naidu NR, 1982. Goat mortality in Andhra pradesh. Indian Veterinary Journal, 59:96-99.

Stefanou D; Tsangaris TH; Lekkas ST, 1975. Pulmonary adenomatosis in the goats in the district of Pieria (Greece). 20th World Veterinary Congress, Thessaloniki, Greece, 495-496.

Stevenson RG; Rehmutulla AJ; Thomsom RG, 1980. Pulmonary adenomatosis (Jaagsiekte) in sheep in Canada. Canadian Veterinary Journal, 21:267-268.

Toumazos P, 1989. First report of sheep pulmonary adenomatosis in Cyprus. British Veterinary Journal, 145(3):289-290; 3 ref.

Tustin RC, 1969. Ovine Jaagsiekte. Journal of the South African Veterinary Medical Association, 40:3-23.

Verwoerd DW; Williamson AL; De Villiers EM, 1980. Aetiology of Jaagsiekte: Transmission by means of subcellular fractions and evidence for the involvement of a retrovirus. Onderstepoort Journal of Veterinary Research, 47:275-280.

Wandera JG, 1971. Sheep pulmonary adenomatosis. Advances of Veterinary Science and Comparative Medicine, 15:251-283.

York DF; Vigne R; Verwoerd DW; Querat G, 1992. Nucleotide sequence of the jaagsiekte retrovirus, an exogenous and endogenous type D and B retrovirus of sheep and goats. Journal of Virology, 66(8):4930-4939; 52 ref.

Youkhana SO, 1995. Pulmonary adenomatosis in Iraqi sheep. Iraqi Journal of Veterinary Sciences, 8(2):267-270; 13 ref.

Distribution References

Adamesteanu C, Rusu M, Baba I, Vesa S, 1969. Pulmonary adenomatosis in sheep in Romania. In: Revista de zootehnie medicina si veterinara, 19 54-60.

Alsenosy A M, Ahmed S S, Arnautović I, Džuvić A, Ivetić V, 1986. First confirmation of ovine pulmonary adenomatosis (jaagsiekte) in two indigenous Barbary ewes in Libya. (Prva verifikacija pulmonalne adenomatoze ovaca (jaagsiekte) kod dvije domace barbara ovce u Libijskoj Dzamahiriji.). Veterinaria, Yugoslavia. 35 (2), 169-178.

Amara A, Jemli M H, Boutouria M, Chetoui C, 1994. First case of adenomatosis in a ewe in Tunisia. (Premier cas d'adenomatose chez une brebis en Tunisie.). Revue d'Élevage et de Médecine Vétérinaire des Pays Tropicaux. 47 (1), 33-34.

Aucamp VP, 1825. Cape Archives, GR 12/4.,

Aynaud M, 1926. (Origin verminouse du cancer pulmonaire de la brebis). In: Comptes rendus des scances de la Societe de Biologie, 95 1540-1542.

Banerjee M, Gupta P P, 1979. Note on Maedi and Jaagziekte in sheep and goats in Ludhiana area of Punjab. Indian Journal of Animal Sciences. 49 (12), 1102-1105.

Bassett H F, Sheehan P, 1989. Outbreak of sheep pulmonary adenomatosis in the Irish Republic. Veterinary Record, 124 (2), 46-47.

CABI Data Mining, 2001. CAB Abstracts Data Mining.,

CABI, Undated. Compendium record. Wallingford, UK: CABI

CABI, Undated a. CABI Compendium: Status as determined by CABI editor. Wallingford, UK: CABI

Christodoulous T, Tarlatis K, 1952. Chronic glandular pneumonia in the sheep (jaagsiekte). In: Deltion tes Hellenikes Kten. Hetaireias, 2 199-208.

Cuba-Caparo A, 1945. (Boletin de la Escuela Nacional de Ciencias Veterinarias)., 1 27.

Cuba-Caparo A, de la Vega E, Copaira M, 1961. Pulmonary adenomatosis of sheep-metastasizing bronchiolar tumours. American Journal of Veterinary Research. 673-682.

Cutlip R C, Young S, 1982. Sheep pulmonary adenomatosis (jaagsiekte) in the United States. American Journal of Veterinary Research. 43 (12), 2108-2113.

Cvjetanovic J, Martinic M, 1962. (Epizooticna plucna adenomatoza 0vaca pao (jaagziekte) n Jugoslaviji). In: Veterinarski Archiv, 32 77-92.

Dadhich H, Sharma G D, 1995. A note on Jaagsiekte and maedi in goats from Rajasthan. Indian Journal of Veterinary Pathology. 19 (2), 140-141.

Damodaran S, 1960. Ovine pulmonary adenomatosis (Jagziekte). Indian Veterinary Journal. 127-138.

Deng PuHui, Hian ZiJian, Bai HuiMin, 1996. Retrospective investigation of pulmonary adenomatosis of sheep in Xinjiang. Chinese Journal of Veterinary Medicine. 22 (1), 3-5.

Drimeier D, Moojen V, Faccini GS, de Oliveira RT, 1998. (Ciencia Rural)., 28 147-150.

Ellis J A, Chavera A E V, DeMartini J C, 1993. Disease conditions in slaughtered sheep from small holder flocks in Peru. Small Ruminant Research. 10 (3), 243-250. DOI:10.1016/0921-4488(93)90129-6

ENCHEV S, TOMOV T, IVANOV I, 1958. Pulmonary adenomatosis of sheep in Bulgaria. Izvestiya na Instituta po Sravnitelna Patologiya na Domashnite Zhivotni. 365-367.

Equiluz C, De Aluja AS, 1981. (Neumonía intersticial progresiva (Maedi) y adenomatosis pulmonar en vísceras de óvidos decomisados). In: Vetrinaria México, 12 235-237.

Gea G S de, González Quintana H, 1992. Pulmonary diseases of sheep in Argentina. (Patologia pulmonar del ovino.). Veterinaria Argentina. 8 (83), 190, 192-193.

Geisel O, 1975. (Zur Morphologie der spontanen Lungadenomatose des Schafes). In: Zentralblat für Veterinä Medizin. B. 22 535-543.

Glávits R, Molnár T, Pálfi V, Tenk M, 1996. Pulmonary adenomatosis in a goat. (Tüdőadenomatosis kecskében.). Magyar Állatorvosok Lapja. 51 (10), 582-584.

Hunter A R, Munro R, 1983. The diagnosis, occurrence and distribution of sheep pulmonary adenomatosis in Scotland 1975 to 1981. British Veterinary Journal. 139 (2), 153-164.

Jakob W, Krauze H, 1965. (Zum Auftreten der enzootischen lung adenomatose in Schafbestanden-Moneastschef fur Veterinarmedizin)., 60 217-223.

Kopczewski A, Salwa A, Baczyński Z, 1986. Structural and seasonal losses in Pomeranian and Merino sheep from adenomatosis and visna-maedi. (Struktura i sezonowosc strat owiec rasy pomorskiej i merynos wywolanych przez adenomatoze i chorobe maedi.). Medycyna Weterynaryjna. 42 (11/12), 673-677.

Kostenko Yu G, 1964. Adenomatosis of sheep. Veterinariya. 41 (11), 34-36 pp.

Krogsrud J, Larsen H J S, Rimstad E, 1996. Visna maedi and pulmonary adenomatosis. (Mæadi og lungeadenomatose.). Norsk Veterinærtidsskrift. 108 (10), 729-736.

Madeira AC, 1949. (Adenocarcinoma em focos multiples do pulmao em um ovino). In: Revista de medicina veterinaria, 44 Lisboa, 95-100.

Marsh H, 1966. Progressive pneumonia of sheep in the United States and its relation to disease of the Jaagsiekte complex. [Proceedings Third Quadrennial Conference on Cancer: Lung tumours in animals, Perugia, Italy], [ed. by Sereril L]. 285-294.

McFadyean J, 1938. (Jaagsiekte). In: Journal of Comparative Pathology and Therapeutics, 51 78-84.

Mitrofanov V M, 1963. Histogenesis of pulmonary adenomatosis in sheep. Arkhiv Patologii. 25 (10), 46-51 pp.

Moraillon P, Yalcin N, 1967. (Adenomatose pulmonaire des ovins en France). [Proceedings of the 18th World Veterinary Congress], 1 323-324.

Naghshineh R, Sohrabi I, 1972. [Pulmonary adenomatosis in sheep in Iran]. Journal of Veterinary Faculty University of Tehran. 28 (No.3), 29-39.

Nilsson N-G, 1984. Tumours of slaughter animals in Sweden. (Tumörer hos slaktdjur.). Svensk Veterinärtidning. 36 (6), 295-297.

Nobel T A, Neumann F, Klopfer U, 1969. Histological patterns of the métastases in pulmonary adenomatosis of sheep (jaagsiekte). Journal of Comparative Pathology. 537-54. DOI:10.1016/0021-9975(69)90074-7

Nobel TA, 1958. Pulmonary adenomatosis (jaagsiekte) in sheep with special reference to its occurrence in Israel. In: Refuah Veterinarith, 15 101-198.

OIE Handistatus, 2005. World Animal Health Publication and Handistatus II (dataset for 2004)., Paris, France: Office International des Epizooties.

OIE, 1998. World Animal Health in 1997., 1-2 Paris, France: Office International des Epizooties.

Prašović S, Ivetić V, Sudarić F, 1991. Pulmonary adenomatosis in a Pramenka sheep. (Plućna adenomatoza kod ovce pramenke.). Veterinaria (Sarajevo). 40 (1-2), 225-230.

Pritchard G C, Done S H, 1990. Concurrent maedi-visna virus infection and pulmonary adenomatosis in a commercial breeding flock in East Anglia. Veterinary Record. 127 (8), 197-200.

Pusterla N, Braun U, Grest P, Ossent P, 1995. Pulmonary adenomatosis in a sheep. Diagnosis by lung biopsy under ultrasonic guidance. (Ein Fall von Lungenadenomatose bei einem Schaf - Diagnose durch Lungenbiopsie unter Ultraschallkontrolle.). Tierärztliche Umschau. 50 (5), 340-343.

Rajya B S, Singh C M, 1964. The pathology of pneumonia and associated respiratory disease of sheep and goats. I. Occurrence of jagziekte and maedi in sheep and goats in India. American Journal of Veterinary Research. 61-67.

Sarkar C R, Chakrabaril A, Deb S, Nandy S N, 1988. Pulmonary adenomatosis (jaagsiekte) of sheep in West Bengal. Indian Veterinary Journal. 65 (4), 353-354.

Schultz L, Somoza A, Weiland F, 1965. (Zum auftreten und zum tumour charakter der enzootischen lungadenomatose des schafes vergleichende unter suchungenin Chile und in der Bundesrepublik Deutschland). In: Deutsche tieraertliche Wochenschrift, 72 458-461.

Seidl K, 1990. Pulmonary adenomatosis of sheep. (Plicní adenomatóza ovcí.). Veterinářství. 40 (12), 539.

Shah A M A, Jasni S, Zamri-Saad M, 1996. More cases of sheep pulmonary adenomatosis [in Malaysia]. Jurnal Veterinar Malaysia. 8 (2), 69-71.

Sharma D N, Rajya B S, Dwivedi J N, 1975. Metastasizing pulmonary adenomatosis (Jaagziekte) in sheep and goats - patho-anatomical studies. Indian Journal of Animal Sciences. 45 (6), 363-370.

Snyder S P, DeMartini J C, Ameghino E, Caletti E, 1983. Coexistence of pulmonary adenomatosis and progressive pneumonia in sheep in the central sierra of Peru. American Journal of Veterinary Research. 44 (7), 1334-1338.

Sriraman P K, Rao P R, Naidu N R G, 1982. Goat mortality in Andhra Pradesh. Indian Veterinary Journal. 59 (2), 96-99.

Stefanou D, Tsangaris T, Lekkas S, 1975. Pulmonary adenomatosis in the goats in the District of Pieria (Greece). Proceedings of the 20th World Veterinary Congress, Thessaloniki. 1204-1208.

Stevenson RG, Rehmutulla AJ, Thomsom RG, 1980. Pulmonary adenomatosis (Jaagsiekte) in sheep in Canada. In: Canadian Veterinary Journal, 21 267-268.

Toumazos P, 1989. First report of sheep pulmonary adenomatosis in Cyprus. British Veterinary Journal. 145 (3), 289-290. DOI:10.1016/0007-1935(89)90081-X

Tustin R C, 1969. Ovine jaagsiekte. Journal of the South African Veterinary Medical Association. 3-23.

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