Invasive Species Compendium

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viral hemorrhagic septicemia virus

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Datasheet

viral hemorrhagic septicemia virus

Summary

  • Last modified
  • 19 November 2019
  • Datasheet Type(s)
  • Invasive Species
  • Preferred Scientific Name
  • viral hemorrhagic septicemia virus
  • Taxonomic Tree
  • Domain: Virus
  •   Group: "Positive sense ssRNA viruses"
  •     Group: "RNA viruses"
  •       Order: Mononegavirales
  •         Family: Rhabdoviridae

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Pictures

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PictureTitleCaptionCopyright
Turbot (Scophthalmus maximus) experimental VHS infection with a virulent freshwater strain, showing haemorrhaging around the eye orbit (arrowed).
TitleExperimental VHS infection with a virulent freshwater strain
CaptionTurbot (Scophthalmus maximus) experimental VHS infection with a virulent freshwater strain, showing haemorrhaging around the eye orbit (arrowed).
CopyrightD. A. Smail
Turbot (Scophthalmus maximus) experimental VHS infection with a virulent freshwater strain, showing haemorrhaging around the eye orbit (arrowed).
Experimental VHS infection with a virulent freshwater strainTurbot (Scophthalmus maximus) experimental VHS infection with a virulent freshwater strain, showing haemorrhaging around the eye orbit (arrowed).D. A. Smail

Identity

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Preferred Scientific Name

  • viral hemorrhagic septicemia virus

International Common Names

  • English: Egtved virus; viral haemorrhagic septicaemia virus

English acronym

  • VHSV

Taxonomic Tree

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  • Domain: Virus
  •     Group: "Positive sense ssRNA viruses"
  •         Group: "RNA viruses"
  •             Order: Mononegavirales
  •                 Family: Rhabdoviridae
  •                     Genus: Novirhabdovirus
  •                         Species: viral hemorrhagic septicemia virus

Distribution Table

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The distribution in this summary table is based on all the information available. When several references are cited, they may give conflicting information on the status. Further details may be available for individual references in the Distribution Table Details section which can be selected by going to Generate Report.

Last updated: 06 Jan 2022
Continent/Country/Region Distribution Last Reported Origin First Reported Invasive Reference Notes

Africa

AlgeriaAbsent, No presence record(s)Jul-Dec-2020
BotswanaAbsent, No presence record(s)
BurundiAbsent, No presence record(s)
Cabo VerdeAbsentJul-Dec-2019
CameroonAbsent, No presence record(s)
Central African RepublicAbsent, No presence record(s)
ComorosAbsent, No presence record(s)Jul-Dec-2018
Congo, Democratic Republic of theAbsent, No presence record(s)
DjiboutiAbsent, No presence record(s)
EgyptAbsentJul-Dec-2019
EritreaAbsent, No presence record(s)
EswatiniAbsent, No presence record(s)
EthiopiaAbsent, No presence record(s)
GhanaAbsentJul-Dec-2018
KenyaAbsent, No presence record(s)Jul-Dec-2019
LesothoAbsent, No presence record(s)Jan-Jun-2019
LibyaAbsentJul-Dec-2019
MadagascarAbsent, No presence record(s)Jul-Dec-2020
MauritiusAbsentJan-Jun-2019
MayotteAbsentJul-Dec-2019
MozambiqueAbsent, No presence record(s)Jul-Dec-2019
NigeriaAbsentJul-Dec-2019
RéunionAbsentJul-Dec-2019
Saint HelenaAbsent, No presence record(s)Jul-Dec-2018
São Tomé and PríncipeAbsent, No presence record(s)
SeychellesAbsent, No presence record(s)Jul-Dec-2018
SomaliaAbsent, No presence record(s)Jan-Jun-2018
South AfricaAbsent, No presence record(s)Jul-Dec-2019
SudanAbsent, No presence record(s)Jul-Dec-2019
TogoAbsent, No presence record(s)
TunisiaAbsentJul-Dec-2019
UgandaAbsent, No presence record(s)
ZimbabweAbsent, No presence record(s)

Asia

ArmeniaAbsentJul-Dec-2020
AzerbaijanAbsent, No presence record(s)Jul-Dec-2018
BahrainAbsent, No presence record(s)
BangladeshAbsent, No presence record(s)Jul-Dec-2020
BhutanAbsent, No presence record(s)Jul-Dec-2018
BruneiAbsent, No presence record(s)
ChinaAbsent, No presence record(s)Jul-Dec-2019
GeorgiaAbsent, No presence record(s)Jul-Dec-2018
Hong KongAbsent, No presence record(s)Jan-Jun-2020
IndiaAbsent, No presence record(s)Jan-Jun-2018
IndonesiaAbsent, No presence record(s)Jan-Jun-2019
IranPresentJan-Jun-2019
IraqAbsentJul-Dec-2019
IsraelAbsent, No presence record(s)Jul-Dec-2020
JapanPresentJul-Dec-2020
JordanAbsent, No presence record(s)Jul-Dec-2018
KazakhstanAbsent, No presence record(s)
KuwaitAbsentJan-Jun-2019
KyrgyzstanAbsentJan-Jun-2019
LebanonAbsent, No presence record(s)
Malaysia
-Peninsular MalaysiaAbsent, No presence record(s)
MaldivesAbsent, No presence record(s)Jan-Jun-2019
MongoliaAbsentJul-Dec-2018
NepalAbsentJul-Dec-2019
North KoreaAbsent, No presence record(s)
OmanAbsent, No presence record(s)
PhilippinesAbsent, No presence record(s)Jul-Dec-2019
Saudi ArabiaAbsent, No presence record(s)Jul-Dec-2019
SingaporeAbsent, No presence record(s)Jul-Dec-2020
South KoreaAbsentJul-Dec-2019
Sri LankaAbsent, No presence record(s)
SyriaAbsent, No presence record(s)
TaiwanAbsent, No presence record(s)
TajikistanAbsentJan-Jun-2019
ThailandAbsent, No presence record(s)Jul-Dec-2019
TurkeyAbsentJul-Dec-2019
TurkmenistanAbsentJan-Jun-2019
United Arab EmiratesAbsent, No presence record(s)Jul-Dec-2020
UzbekistanAbsent, No presence record(s)
VietnamAbsent, No presence record(s)Jul-Dec-2019

Europe

AndorraAbsent, No presence record(s)Jul-Dec-2019
AustriaPresentJul-Dec-2019
BelarusAbsent, No presence record(s)Jul-Dec-2019
BelgiumPresentJul-Dec-2019
Bosnia and HerzegovinaAbsent, No presence record(s)Jul-Dec-2019
CroatiaAbsentJul-Dec-2019
CyprusAbsent, No presence record(s)Jul-Dec-2019
CzechiaPresentJul-Dec-2019
DenmarkAbsentJul-Dec-2020
EstoniaAbsentJul-Dec-2019
Faroe IslandsAbsent, No presence record(s)Jan-Jun-2018
FinlandAbsentJul-Dec-2019
FrancePresentJul-Dec-2019
GermanyPresentJul-Dec-2019
GreeceAbsent, No presence record(s)Jul-Dec-2019
HungaryAbsent, No presence record(s)Jul-Dec-2019
IcelandAbsentJul-Dec-2019
IrelandAbsentJul-Dec-2019
Isle of ManAbsent, No presence record(s)
ItalyPresent, LocalizedJul-Dec-2020
JerseyAbsent, No presence record(s)
LatviaAbsentJul-Dec-2020
LiechtensteinAbsent, No presence record(s)Jul-Dec-2019
LithuaniaAbsentJul-Dec-2019
MaltaAbsent, No presence record(s)Jan-Jun-2019
MoldovaAbsent, No presence record(s)Jul-Dec-2020
NetherlandsAbsentJul-Dec-2019
North MacedoniaAbsent, No presence record(s)Jul-Dec-2019
NorwayAbsentJul-Dec-2019
PolandAbsentJul-Dec-2019
PortugalAbsentJul-Dec-2019
RomaniaAbsentJan-Jun-2020
RussiaAbsent, No presence record(s)
SerbiaAbsent, No presence record(s)Jul-Dec-2019
SlovakiaAbsentJan-Jun-2020
SloveniaAbsentJan-Jun-2019
SpainAbsentJul-Dec-2020
SwedenPresentJul-Dec-2019; in wild animals only
SwitzerlandAbsentJul-Dec-2020
UkraineAbsentJan-Jun-2019
United KingdomAbsentJul-Dec-2019
-Northern IrelandAbsent, No presence record(s)

North America

BahamasAbsent, No presence record(s)Jul-Dec-2018
BarbadosAbsent, No presence record(s)Jul-Dec-2020
BelizeAbsent, No presence record(s)Jul-Dec-2019
BermudaAbsent, No presence record(s)
British Virgin IslandsAbsent, No presence record(s)
CanadaPresent, LocalizedJul-Dec-2019; in wild animals only; suspected in domestic animals
Cayman IslandsAbsent, No presence record(s)
Costa RicaAbsent, No presence record(s)Jul-Dec-2019
CubaAbsent, No presence record(s)Jan-Jun-2019
CuraçaoAbsent, No presence record(s)
DominicaAbsent, No presence record(s)
Dominican RepublicAbsent, No presence record(s)
El SalvadorAbsent, No presence record(s)Jul-Dec-2019
GreenlandAbsent, No presence record(s)Jul-Dec-2018
GuadeloupeAbsentJul-Dec-2019
GuatemalaAbsent, No presence record(s)
HaitiAbsent, No presence record(s)
HondurasAbsent, No presence record(s)
JamaicaAbsent, No presence record(s)
MartiniqueAbsentJul-Dec-2019
MexicoAbsentJul-Dec-2019
NicaraguaAbsent, No presence record(s)
PanamaAbsent, No presence record(s)
Saint Kitts and NevisAbsent, No presence record(s)
Saint Vincent and the GrenadinesAbsent, No presence record(s)
Trinidad and TobagoAbsent, No presence record(s)
United StatesPresentJul-Dec-2020

Oceania

AustraliaAbsent, No presence record(s)Jul-Dec-2019
Cook IslandsAbsent, No presence record(s)Jan-Jun-2019
Federated States of MicronesiaAbsent, No presence record(s)Jan-Jun-2019
French PolynesiaAbsent, No presence record(s)Jan-Jun-2019
KiribatiAbsent, No presence record(s)Jan-Jun-2019
Marshall IslandsAbsent, No presence record(s)Jan-Jun-2019
New CaledoniaAbsentJul-Dec-2019
New ZealandAbsent, No presence record(s)Jul-Dec-2019
PalauAbsent, No presence record(s)Jan-Jun-2019
Papua New GuineaAbsentJan-Jun-2019
SamoaAbsentJan-Jun-2019
TongaAbsent, No presence record(s)Jan-Jun-2020
VanuatuAbsent, No presence record(s)Jan-Jun-2019

South America

ArgentinaAbsent, No presence record(s)Jul-Dec-2019
BoliviaAbsent, No presence record(s)Jan-Jun-2019
BrazilAbsent, No presence record(s)Jul-Dec-2019
ChileAbsent, No presence record(s)Jan-Jun-2019
ColombiaAbsent, No presence record(s)Jan-Jun-2019
EcuadorAbsent, No presence record(s)Jan-Jun-2019
Falkland IslandsAbsent, No presence record(s)Jul-Dec-2018
French GuianaAbsentJul-Dec-2019
GuyanaAbsent, No presence record(s)
ParaguayAbsent, No presence record(s)Jul-Dec-2020
PeruAbsent, No presence record(s)Jul-Dec-2019
UruguayAbsentJul-Dec-2020
VenezuelaAbsent, No presence record(s)Jan-Jun-2019

Pathogen Characteristics

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Virus morphology and biochemistry

Viral hemorrhagic septicemia virus is placed within the family Rhabdoviridae in the Novirhabdovirus genus (Einer-Jensen, et al., 2004), because it is currently regarded as distant to viruses in the lyssavirus genus on genetic grounds (Wunner et al., 1995). The type species of Novirhabdovirus is infectious haematopoietic necrosis virus (IHNV). It is a bullet-shaped virus and, by electron microscopy, measures 70 nm width by 180 nm length. It is also enveloped, and the envelope contains the membrane glycoprotein, which is the major neutralizing surface antigen (Jørgensen et al., 1995). This is in common with other mammalian rhabdoviruses and the fish rhabdovirus IHNV (Luo et al., 1988; Benmansour et al., 1991; Huang, 1993).

Viral hemorrhagic septicemia virus is composed of a single-stranded ribonucleic acid (RNA) molecule, four structural proteins and the virion-associated polymerase (Lenoir and de Kinkelin, 1975; de Kinkelin et al., 1980; Benmansour et al., 1994). The structural proteins are the envelope glycoprotein (G), the nucleoprotein (N), the polymerase-associated protein (M1) and the matrix protein (M2). In addition, a non-virion (NV) protein is expressed in infected cells, but the function of this is not known (Schuetze et al., 1996; Kurath et al., 1997).

There have been no research studies on the assembly of the structural proteins of VHSV in relation to the nucleic acid. Knowledge of virus assembly for rhabdoviruses overall is derived from studies in particular on the type vesiculovirus, vesicular stomatitis virus (VSV), and the type lyssavirus, rabies virus (RV).

The RNA is helically wound and nucleoprotein has a close association with the RNA molecule, although the precise stabilizing forces have not been described. In RV, the internal matrix protein M1 is closely associated with the N protein (Prehaud et al., 1992) and in VSV the M1 protein is associated with the polymerase (L) protein (Banerjee and Barik, 1992). In VSV, the external matrix protein (M2) is closely associated with the nucleoprotein core structure (Wilson and Lenard, 1981) and the external envelope glycoprotein (G), which it stabilizes (Lyles et al., 1992).

Forms of the virus

In common with many RNA viruses with a negative-strand polarity genome, defective interfering (DI) particles are readily produced which are shorter and have a smaller RNA molecule than normal infectious particles. Such particles interfere with the standard complete infectious virus at the cellular level by competing for cell receptor binding sites and thereby blocking efficient replication of the standard full length virus (Wunner, 1985).

Serotypes and strains

Three serotypes of VHSV have been described: type 1, represented by strain F1 (Denmark), type 2, represented by the Heddedam isolate from Denmark, and type 3, represented by the French strain 23/75 isolated from brown trout by de Kinkelin and Le Berre (1977). These three serotypes were defined by a serum neutralization test. However, as Olesen et al. (1993) reported, there was considerable overlap of strains within and between these serotypes. These authors attempted to define more realistic serogroups, using cross-reacting polyclonal antiserum and four neutralizing monoclonal antibodies (MAbs). It was suggested that three serogroups were recognizable: serogroup I, neutralized by all four MAbs and the anti-F1 antibody, serogroup II, neutralized by only one MAb and the anti-F1 antibody, and serogroup III, not neutralized by any MAb but with low or no neutralization by the F1 antibody.

Although three serogroups were identified, Olesen et al. (1993) pointed out that 120 of 127 isolates were neutralized by an anti-F1 antiserum and these therefore showed common antigenic determinants. Serogroups were therefore in reality subtypes within a single serotype and the definition of the subtypes would be dependent on the MAbs used. What emerged from the study of newly classified VHS viruses by Olesen et al. (1993) was that there had been an antigenic shift from the period 1965-81 to 1992 in Denmark, by which the group I isolates, including F1 type isolate, had been largely displaced by new group II isolates in a single year from 1991 to 1992. What is known about new marine VHSV strains in European waters from cod and haddock in the North Sea and turbot from Gigha Island is that all the three neutralization serogroups are represented. It is also possible that the freshwater serotypes in Denmark had their origin in the marine environment.

In this connection, the glycoprotein gene sequence comparisons for a variety of marine and freshwater strains by Stone et al. (1997) are relevant. Phylogenetic analysis of a 360-nucleotide region of the G gene revealed three genogroups. Dendrograms based on the deduced amino acid sequence derived two genogroups. In genogroup II, strain 23-75 from brown trout in France, cod-79 (the first cod isolate from Denmark) and the Scottish Gigha turbot isolate (814) showed 100% homology for amino acid sequence. It was therefore postulated that these isolates from both fresh water and sea water shared a common evolution.

Genetics

The recent review article (Einer-Jensen et al., 2004) points to a likely marine origin for the freshwater virulent isolates of VHS virus and synthesizes much of the available information in the literature. A previous paper by Thiery et al., (2003) reported G gene sequence information on historical French isolates from 1971 to 1999 and indicated a good correlation between the geographical origin of the isolates and their genetic characteristics. In another significant paper, Betts and Stone (2000) reported a complete genome sequence analysis of two virulent freshwater and two avirulent marine isolates, in a search for loci of virulence. As few as 10 amino acid substitutions were identically substituted between the freshwater and marine isolates, indicating a very limited number of amino acid substitutions may be required for a change of VHSV virulence for salmonids.

Host Animals

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Animal nameContextLife stageSystem
Ctenopharyngodon idella (grass carp)Aquatic|Adult; Aquatic|FryEnclosed systems/Ponds
Oncorhynchus mykiss (rainbow trout)
Oncorhynchus tshawytscha (chinook salmon)Domesticated hostAquatic|Fry
Psetta maxima (turbot)Aquatic|Adult; Aquatic|Broodstock; Aquatic|FryEnclosed systems/Tanks
Salmo salar (Atlantic salmon)Domesticated host; Experimental settings; Wild hostAquatic|AdultEnclosed systems/Cages

References

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Banerjee AK, Barik S, 1992. Gene expression of vesicular stomatitis virus genome RNA. Virology, 188:417-428

Benmansour A, Leblois H, Coulon P, Tuffereau C, Gaudin Y, Flamand A, Lafay F, 1991. Antigenicity of rabies virus glycoprotein. Journal of Virology, 65(8):4198-4203; 27 ref

Benmansour A, Paubert G, Bernard J, Kinkelin Pde, 1994. The polymerase-associated protein (M1) and the matrix protein (M2) from a virulent and an avirulent strain of viral hemorrhagic septicemia virus (VHSV), a fish rhabdovirus. Virology (New York), 198(2):602-612; 42 ref

Betts AM, Stone DM, 2000. Nucleotide sequence analysis of the entire coding regions of virulent and avirulent strains of viral haemorrhagic septicaemia virus. Virus Genes, 20(3):259-262

Einer-Jensen K, Ahrens P, Forsberg R, Lorenzen N, 2004. Evolution of the fish rhabdovirus viral haemorrhagic septicaemia virus. Journal of General Virology. 85:1167-1179

Huang C, 1993. Mapping of antigenic sites of infectious hematopoietic necrosis virus glycoprotein. PhD thesis. Seattle, USA: University of Washington

Jrgensen PEV, Einer-Jensen K, Higman KH, Winton JR, 1995. Sequence comparison of the central region of the glycoprotein gene of neutralizable, non-neutralizable, and serially passed isolates of viral haemorrhagic septicaemia virus. Diseases of Aquatic Organisms, 23(1):77-82

Kinkelin Pde, Bearzotti-Le Berre M, Bernard J, 1980. Viral hemorrhagic septicemia of rainbow trout: selection of a thermoresistant virus variant and comparison of polypeptide synthesis with the wild-type virus strain. Journal of Virology, 36(3):652-658

Kinkelin Pde, Le Berre M, 1977. Isolement d’un rhabdovirus pathogène de la truite fario (Salmo trutta, L. 1766). Comptes Rendus Hebdomadaires des Séances, Académie des Sciences (Paris), 284:101-104

Kurath G, Higman KH, Björklund HV, 1997. Distribution and variation of NV genes in fish rhabdoviruses. Journal of General Virology, 78(1):113-117

Lenoir G, Kinkelin PDe, 1975. Fish rhabdoviruses: comparative study of protein structure. Journal of Virology, 16(2):259-262

Luo L, Li Y, Snyder RM, Wagner RR, 1988. Point mutations in glycoprotein gene of vesicular stomatitis virus (New Jersey serotype) selected by resistance to neutralization by epitope-specific monoclonal antibodies. Virology, 163(2):341-348; 27 ref

Lyles DS, McKenzie M, Parce JW, 1992. Subunit interactions of vesicular stomatitis virus envelope glycoprotein stabilized by binding to viral matrix protein. Journal of Virology, 66(1):349-358; 24 ref

OIE Handistatus, 2005. World Animal Health Publication and Handistatus II (data set for 2004). Paris, France: Office International des Epizooties

Olesen NJ, Lorenzen N, Jrgensen PEV, 1993. Serological differences among isolates of viral haemorrhagic septicaemia virus detected by neutralizing monoclonal and polyclonal antibodies. Diseases of Aquatic Organisms, 16(3):163-170

Préhaud C, Nel K, Bishop DHL, 1992. Baculovirus-expressed rabies virus M1 protein is not phosphorylated: it forms multiple complexes with expressed rabies N protein. Virology (New York), 189(2):766-770; 12 ref

Schütze H, Enzmann PJ, Mundt E, Mettenleiter TC, 1996. Identification of the non-virion (NV) protein of fish rhabdoviruses viral haemorrhagic septicaemia virus and infectious haematopoietic necrosis virus. Journal of General Virology, 77(6):1259-1263

Stone DM, Way K, Dixon PF, 1997. Nucleotide sequence of the glycoprotein gene of viral haemorrhagic septicaemia (VHS) viruses from different geographical areas: a link between VHS in farmed fish species and viruses isolated from North Sea cod (Gadus morhua L.). Journal of General Virology, 78(6):1319-1326

Thiéry R, Boisséson Cde, Jeffroy J, Castric J, Kinkelin Pde, Benmansour A, 2003. Phylogenetic analysis of viral haemorrhagic septicaemia virus (VHSV) isolates from France (1971-1999). Diseases of Aquatic Organisms, 52(1):29-37

Wilson T, Lenard J, 1981. Interactions of wild type and mutant M protein of vesicular stomatitis virus with nucleocapsids in vitro. Biochemistry, 20:1349-1354

Wunner WH, 1985. Growth, purification and titration of rhabdoviruses. In: Mahy BWJ, ed. Virology, a Practical Approach. Oxford: IRL Press, 79-93

Wunner WH, Calisher CH, Dietzgen RG, Jackson AO, Kitajima EW, Lafon M, Leong JC, Nichol S, Peters D, Smith JS, Walker PJ, 1995. Family Rhabdoviridae. In: Murphy FA, Fauquet CM, Bishop DHL, Ghabrial SA, Jarvis AW, Martelli GP, Mayo MA, Summers MD, eds. Virus Taxonomy. Sixth Report of the International Committee on Taxonomy of Viruses. Archives of Virology, Supplement 10, 275-288

Distribution References

OIE Handistatus, 2005. World Animal Health Publication and Handistatus II (dataset for 2004)., Paris, France: Office International des Epizooties.

OIE, 2018. World Animal Health Information System (WAHIS): Jul-Dec. In: OIE-WAHIS Platform, Paris, France: OIE (World Organisation for Animal Health). unpaginated. https://wahis.oie.int/

OIE, 2018a. World Animal Health Information System (WAHIS): Jan-Jun. In: OIE-WAHIS Platform, Paris, France: OIE (World Organisation for Animal Health). unpaginated. https://wahis.oie.int

OIE, 2019. World Animal Health Information System (WAHIS): Jul-Dec. In: OIE-WAHIS Platform, Paris, France: OIE (World Organisation for Animal Health). unpaginated. https://wahis.oie.int/

OIE, 2019a. World Animal Health Information System (WAHIS): Jan-Jun. In: OIE-WAHIS Platform, Paris, France: OIE (World Organisation for Animal Health). unpaginated. https://wahis.oie.int/

OIE, 2020. World Animal Health Information System (WAHIS): Jul-Dec. In: OIE-WAHIS Platform, Paris, France: OIE (World Organisation for Animal Health). unpaginated. https://wahis.oie.int/

OIE, 2020a. World Animal Health Information System (WAHIS). Jan-Jun. In: OIE-WAHIS Platform, Paris, France: OIE (World Organisation for Animal Health). unpaginated. https://wahis.oie.int/

Distribution Maps

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