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Cowpox virus is a member of the genus Orthopoxvirus, and therefore is closely related to smallpox virus (now eradicated) and vaccinia virus (the smallpox vaccine). Cowpox virus, despite its name (and the claims of older texts), is endemic in wild rodents (Baxby and Bennett, 1999). Occasionally other hosts can become infected, most commonly cats but also cattle, various zoo animals, dogs and humans, either directly from rodents or from cattle or cats. Different strains of cowpox virus, possibly with different host ranges, are found in different areas. Infection of cattle is now rarely reported, perhaps because of the hygienic precautions taken in most modern dairy herds (Baxby, 1977). Indeed, it probably never was common in cattle; even Edward Jenner had difficulty finding cases for use as the source of his smallpox vaccine. Despite its name, the principal poxvirus infection of cattle is pseudocowpox virus, a member of the Parapoxvirus genus.
In addition to wild rodents (in which infection is endemic), cowpox has been reported in a wide range of domestic mammalian hosts. These include: cattle (Gibbs et al., 1973), domestic cats (Gaskell et al., 1983; Bennett et al., 1986, 1990; Mahnel et al., 1989; Maenhout et al., 1991; Bomhard et al., 1992; Nowotny, 1996), domestic dogs (Bomhard et al., 1992; Smith et al., 1999), horses (Pfeffer et al., 1999) and various zoo animals such as big cats (Marennikova et al., 1977b, 1984; Baxby et al., 1982), beavers (Hentschke et al., 1999), anteaters (Marennikova et al., 1977b), alpacas (Schüppel et al., 1997), okapi (Zwart et al., 1971), elephants and rhinoceroses (Pilaski et al., 1988).
Published accounts of the distribution of cowpox suffer from both under- and over-reporting. Unless clinically obvious disease is seen and recognized in domestic animals or humans, it is unlikely to be reported, while pseudocowpox is often incorrectly reported as cowpox and, particularly in the older literature, vaccinia (including buffalopox viruses) and cowpox viruses were often not distinguished. Reliable reports of characterized virus suggest that cowpox virus is found throughout much of Europe (although not Ireland, the Iberian Peninsula or, possibly, the Balkans), possibly in parts of the Middle East and eastwards to the Urals in the North and Turkmenistan in the South. It does appear to be widespread in Africa, the Americas, Australasia or the Far East.
The distribution in this summary table is based on all the information available. When several references are cited, they may give conflicting information on the status. Further details may be available for individual references in the Distribution Table Details section which can be selected by going to Generate Report.Last updated: 10 Jan 2020
|Continent/Country/Region||Distribution||Last Reported||Origin||First Reported||Invasive||Reference||Notes|
|Russia||Present||Present based on regional distribution.|
Vesicular and ulcerative lesions of cowpox are often limited to the skin in non-reservoir hosts, although systemic lesions, particularly in the lungs and abdominal cavity, are sometimes encountered. The microscopic changes include epithelial hyperplasia and hypertrophy, lysis of the prickle cell layer in the epidermis and microscopic vesicle formation, and characteristic intracytoplasmic, eosinophilic inclusion bodies.
A presumptive diagnosis can often be made on clinical signs alone, particularly in cats. However, confirmation requires isolation of the virus and its characterization. Histology, especially if immunostaining is used, can confirm an orthopoxvirus infection, as can serology. Serology has the advantage of being available retrospectively. Electron microscopy can provide a rapid result, but only to the level of confirming a non-parapoxvirus, poxvirus infection.
|Respiratory Signs / Nasal mucosal ulcers, vesicles, erosions, cuts, tears, papules, pustules||Cattle & Buffaloes|All Stages||Sign|
|Skin / Integumentary Signs / Scarred skin||Cattle & Buffaloes|All Stages||Sign|
|Skin / Integumentary Signs / Skin papules||Cattle & Buffaloes|All Stages||Sign|
|Skin / Integumentary Signs / Skin pustules||Cattle & Buffaloes|All Stages||Sign|
|Skin / Integumentary Signs / Skin ulcer, erosion, excoriation||Cattle & Buffaloes|All Stages||Sign|
|Skin / Integumentary Signs / Skin vesicles, bullae, blisters||Cattle & Buffaloes|All Stages||Sign|
No clinical disease is seen in most wild rodent hosts (Bennett et al., 1997; Feore et al., 1997). The pathogenesis of feline cowpox follows the typical pattern of a systemic poxvirus infection (Bennett et al., 1989). A single primary skin lesion develops at the site of infection, usually the head or a forelimb, within a few days. A white cell-mediated viraemia follows, with virus replication in lymphoid tissue, the lungs and turbinates. This lasts approximately 5 days, and secondary, widespread skin lesions appear just over a week after the primary lesion. Small erythematous nodules increase in size over 2-3 days to become scabbed ulcers approximately 0.5-1 cm across. These gradually heal, so that by 4-6 weeks the dried scabs separate leaving small bald patches. More severe disease, such as pneumonia or large or non-healing lesions, is often associated with immunosuppression, and may result from co-infection with feline leukaemia or feline immunodeficiency viruses (FeLV or FIV), or some other concurrent illness (Bennett et al., 1986, 1990; Brown et al., 1989).
In cattle and humans, only primary lesions at sites of inoculation are usually seen. The lesions of natural bovine cowpox are usually found only on the teats of dairy cows (Gibbs et al., 1973). This may reflect areas of skin most likely to be both damaged and to come into contact with rodent-contaminated material. The usual route of infection in humans is also through a break in the skin, most often the hands or face, including eyes. Human lesions can vary in size and severity, and are often very painful (Baxby et al., 1994). Local lymphadenopathy and systemic signs such as pyrexia and nausea are common, and many cases require hospitalization. More severe cowpox, with multiple lesions and (rarely) death, has been reported, usually associated with immunosuppression (Czerny et al., 1997).
Cowpox virus is endemic in wild rodents, particularly voles of the genera Microtus and Clethrionomys, and mice of the genus Apodemus (Lvov et al., 1988; Crouch et al., 1995; Boulanger et al., 1996; Tryland et al., 1998b; Begon et al., 1998, 1999; Chantrey et al., 1999). In some areas, for example at the eastern extreme of its range, other rodent hosts such as gerbils (Meriones and Rhombomys) and suslicks (Spermophilus) (Marennikova et al., 1977a, 1978, 1984; Tsanava et al., 1989a, b). In Georgia and Russia, infection of rats (Rattus rattus) has been reported, but there is no serological evidence of infection of rats or mice (Mus musculus) in the UK.
Infection of other hosts presumably results from contact with rodents. The most commonly reported accidental host is the domestic cat, at least in Western Europe, which appears to become infected through hunting wild rodents, and is also an important liaison host; more than 50% of human cases can be traced to contact with a domestic cat (Willemse and Egberink, 1985; Czerny et al., 1991; Baxby et al., 1994). Antibody thought to be due to cowpox has also been reported in foxes (Mayr et al., 1995; Henning et al., 1995; Müller et al., 1996), although experimentally they have proved difficult to infect with a strain of virus from the UK (Boulanger et al., 1995).
None of the details of transmission amongst and from rodents are known, although infection rates in wild populations clearly depend on population size and, apparently, specific behaviours (Begon et al., 1999). Indeed, cowpox is most studied currently as a model endemic infection for testing theoretical concepts of disease ecology.
Disease in other hosts is sporadic, but where enough data have been collected, can be seen to follow infection dynamics in the reservoir hosts. In Western Europe, for example, infection of cats, elephants and humans is most common in the autumn, and can be seen to follow the infection and population dynamics of wild rodents (Bennett et al., 1986; Pilaski et al., 1988; Bomhard et al., 1992; Baxby et al., 1994).
Cowpox is a zoonosis, human infection occurring usually through contamination of a break in the skin (Baxby et al., 1994). Infections are usually self-limiting if painful. The immunosuppressed are particularly at risk of severe disease (Czerny et al., 1991). Many human cases can be traced to contact with an infected cat, and some to direct or indirect contact with rodents (Postma et al., 1991). However, human cowpox is rare; approximately 1-2 cases are reported each year in the UK, despite widespread infection of wild rodents (Baxby and Bennett, 1997).
There is no specific treatment, although cidofir has been used successfully to treat experimental cowpox in laboratory animals (Bray et al., 2000).
Elephants and other zoo animals are sometimes vaccinated with vaccinia virus (Pilaski et al., 1988), although stocks of this can be hard to come by. Generally, the incidence in non-wild animals is too low to make prevention and control schemes cost-effective. General good practice in hygiene in dairy farms reduce the chances of disease transmission.
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Claudy AL, Gaudin OG, Granouillet R, 1982. Poxvirus disease in dariers disease. Clinical and Experimental Dermatology, 7:261-266.
Cronqvist J, Ekdahl K, Kjartansdottir A, Bauer B, Klinker M, 1991. Cowpox - en kattsjuka hos manniska. Lakartidningen, 88:32-33.
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Feore SM, Bennett M, Chantry J, Jones T, Baxby D, Begon M, 1997. The effect of cowpox virus infection on fecundity in bank voles and wood mice. Proceedings of the Royal Society, B, 264:1-5.
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Gibbs EPJ, Johnson RH, Collings DF, 1973. Cowpox in a dairy herd in the United Kingdom. Veterinary Record, 92:56-64.
Hentschke J, Meyer H, Wittstatt U, Ochs A, Burkhardt S, Aue A, 1999. An outbreak of cowpox in beavers (Castor fiber canadensis) and bearcats (Ailurus fulgens) in a Berlin zoo. Tierärztliche Umschau, 54(6):311-317; 8 ref.
Lvov SD, Gromashevskyi VL, Marennikova SS, Bogoyavlenskyi GV, Bajluk FN Butenko AM, Gushchina E, Shelukhina, EM, Thukova OA, Morozova TN, 1988. Poxvirus isolation from Microtus oeconomus Pal. 1776 in Colsky peninsula. Vop Virus, 1:92.
Mahnel H, Czerny CP, Mayr A, 1989. Detection and identification of poxvirus in domestic cats. Journal of Veterinary Medicine, B (Infectious Diseases, Immunology, Food Hygiene, Veterinary Public Health), 36(3):231-236; 22 ref.
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Marennikova SS, Maltseva NN, Korneeva VI, Garanina NM, 1977b. Outbreak of pox disease among carnivora (Felidae) and Edentata. Journal of Infectious Diseases, 135:358-366.
Marennikova SS, Shelukhina EM, Fimina V, 1978. Pox infection in white rats. Laboratory Animals, 12:33-36.
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Müller T, Henning K, Kramer M, Czerny CP, Meyer H, Ziedler K, 1996. Seroprevalence of orthopox virus specific antibodies in red foxes (Vulpes vulpes) in the Federal State Brandenburg, Germany. Journal of Wildlife Diseases, 32(2):348-353; 31 ref.
Nowotny N, Fischer OW, Schilcher F, Schwendenwein I, Loupal G, Schwarzmann T, Meyer J, Hermanns W, 1994. Poxviral infections in domestic cats: clinical, histopathological, virological and epidemiological studies. Wiener Tierärztliche Monatsschrift, 81(12):362-369; [13 fig.]; 38 ref.
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Schonbauer M, Schonbauer-Langle A, Kobl S, 1982. Pockeninfektion bei einer Hauskatze. Zentralblatt fur Veterinarmedizin, B29:434-440.
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Tryland M, Sandvik T, Hansen H, Haukenes G, Holtet L, Bennett M, Mehl R, Moens U, Olsvik O, Traavik T, 1998. Characteristics of four cowpox virus isolates from Norway and Sweden. APMIS, Acta Pathologica, Microbiologica et Immunologica Scandinavica, 106(6):623-635; 47 ref.
Tsanava SA, Sakvarelidze LA, Shelukhina EM, 1989. Serologic survey of wild rodents in Georgia for antibodies to orthopoxviruses. Acta Virologica, 33(1):91; 10 ref.
Zwart P, Gispen R, Peters C, 1971. Cowpox in okapi (Okapia johnstoni) at the Rotterdam zoo. British Veterinary Journal, 127:20-24.
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Bennett M, Crouch A J, Begon M, Duffy B, Feore S, Gaskell R M, Kelly D F, McCracken C M, Vicary L, Baxby D, 1997. Cowpox in British voles and mice. Journal of Comparative Pathology. 116 (1), 35-44. DOI:10.1016/S0021-9975(97)80041-2
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CABI, Undated. Compendium record. Wallingford, UK: CABI
CABI, Undated a. CABI Compendium: Status inferred from regional distribution. Wallingford, UK: CABI
CABI, Undated b. CABI Compendium: Status as determined by CABI editor. Wallingford, UK: CABI
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Cronqvist J, Ekdahl K, Kjartansdottir A, Bauer B, Klinker M, 1991. (Cowpox - en kattsjuka hos manniska). In: Lakartidningen, 88 32-33.
Czerny C P, Eis-Hübinger A M, Mayr A, Schneweis K E, Pfeiff B, 1991. Animal poxviruses transmitted from cat to man: current event with lethal end. Journal of Veterinary Medicine. Series B. 38 (6), 421-431. DOI:10.1111/j.1439-0450.1991.tb00891.x
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Hentschke J, Meyer H, Wittstatt U, Ochs A, Burkhardt S, Aue A, 1999. An outbreak of cowpox in beavers (Castor fiber canadensis) and bearcats (Ailurus fulgens) in a Berlin zoo. (Kuhpocken bei kanadischen bibern (Castor fiber canadensis) und Katzenbären (Ailurus fulgens).). Tierärztliche Umschau. 54 (6), 311-317.
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