Invasive Species Compendium

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Abstract Full Text

Biochemical effect of induced sub acute toxicity of Parthenium hysterophorus L. and its amelioration with Prosopis cineraria (L.) druce leaves in Wistar albino rats.

Abstract

An ameliorative effect of Prosopis cineraria leaves on biochemical parameters against induced sub acute toxicity of Parthenium hysterophorus L. in Wistar albino rats was studied. A total of eighty clinically healthy adult albino rats between 2 and 3 months of age of either sex were divided in eight experimental groups each comprising of ten rats. Parthenium toxicity was induced by oral feeding of ethanolic extract of Parthenium at 150, 300 and 450 mg/kg body weight in group II, III and IV, respectively for 28 days. Group V, VI and VII were fed with ethanolic extract of Parthenium at 150, 300 and 450 mg/kg body along with 200 mg/kg body weight of methanolic extract of leaves of Prosopis cineraria. Group I served as control while group VIII was kept as treatment control and fed only methanolic extract of leaves of Prosopis cineraria at 200 mg/kg body weight. The treated rats showed a significant (P<0.05) increase in alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphate (ALP), serum creatinine and serum urea level receiving the different dose of parthenium which indicated a deleterious effect of parthenium on liver cells. Significant reduction of serum total protein was observed in group II, III and IV. Prosopis cineraria could restore the above in group treated with Parthenium at low dose level.