Latent tuberculosis infection: updated and consolidated guidelines for programmatic management.
This consolidated guideline document includes the most recent and comprehensive set of WHO recommendations for the programmatic management of latent tuberculosis infection (LTBI) and will facilitate implementation of the End TB Strategy. Included are updated recommendations from the 2011 WHO guidelines on intensified tuberculosis (TB) case-finding and isoniazid preventive therapy for people living with human immunodeficiency virus (HIV) infection in resource-constrained settings as well as recommendations on the use of LTBI testing. Other relevant recommendations approved by the guideline review committee are also included. This document is expected to provide the basis and rationale for the development of national guidelines for LTBI management, adapted to the national and local epidemiology of TB, the availability of resources, the health infrastructure and other national and local determinants. The guidelines are to be used primarily in national TB and HIV control programmes or their equivalents in ministries of health and for other policy-makers working on TB and HIV and infectious diseases. They are also appropriate for officials in other line ministries with work in the areas of health, including prison services, social services and immigration (such as ministries of justice or correctional services) and clinicians and public health practitioners working on TB, HIV, infectious diseases, prevention, child health and noncommunicable diseases such as chronic kidney disease and cancer.