Screening and isolation of cytotoxicity in vitro from invasive plant Macfadyena unguis-cati L. (Bignoniaceae).
In order to screen and isolate the active constituents from invasive plant Macfadyena unguis-cati L. (Bignoniaceae), the anti-proliferative effects of SMMC7721, Bel7402 by different solvent extraction fractions of ethanol extracts of M. unguis-cati in vitro were studied by using MTT assay. The results showed that the chloroform fraction of ethanol extracts had strong inhibitory effect on liver cancer cells, and then was petroleum ether fraction. An active constituent isolated from chloroform fraction, ursolic acid, had strong inhibitory effect. Therefore, invasive plant M. unguis-cati L. has cytotoxicity in vitro, and one of the main active components is ursolic acid.