Invasive Species Compendium

Detailed coverage of invasive species threatening livelihoods and the environment worldwide

Abstract

Synthesis of a combinatorial library of amides and its evaluation against the fall armyworm, Spodoptera frugiperda.

Abstract

The fall armyworm Spodoptera frugiperda is a polyphagous pest that causes important damage in different regions of America and mainly affects corn crops in both tropical and subtropical areas. Currently, control relies on both transgenic plants and/or chemical pesticides. In this work we describe the preparation of an indexed combinatorial library of amides and its toxic effect by contact against S. frugiperda. (E)-1-(1-Piperidinyl)-3-[4-(trifluoromethoxy)phenyl]-2-propen-1-one was the most active compound with an LD50=0.793 µg mg-1 of larva. This amide was also evaluated by ingestion and at the lowest concentration (1 mg kg-1) achieved 83.3% mortality.