Abstract
Inhibitory effects of medicinal herbs on Cytochrome P450 drug metabolizing enzymes.
Abstract
The MeOH extract, CH2Cl2 fraction, EtOAc fraction, n-BuOH fraction and H2O fraction of 23 Korean medicinal herbs were tested for their inhibitory effects on cytochrome P450 (Cyp) 1A1/2, 2B1/2, 2E1. Among the tested samples, the extracts of Selaginella tamariscina, Euonymus alatus, Salvia miltiorrhiza, Angelica acutiloba, Rheum palmatum, Paeonia moutan [Paeonia suffruticosa], Scutellaria barbata, Tribulus terrestris, Hedyotis diffusa, Curcuma zedoaria, Rehmannia glutinosa, Melandrium firmum, Achyranthes bidentata [Achyranthes japonica], Leonurus sibiricus, Panax ginseng, Paeonia lactiflora, Poncirus trifoliata, Cnidium officinale, Cyperus rotundus and Corydalis ternata and that of the rodent, Trogopterus xanthipes, showed significant inhibitory effects on Cyp 1A1/2, 2B1/2, 2E1. The IC50 values of these extracts were found to be below 50 µg/ml.
