Evaluation of tick-borne encephalitis DNA vaccines in monkeys.
The evaluation of naked DNA vaccines for tickborne encephalitis in mice has previously been reported. It was shown that homologous and heterologous protective immunity could be achieved by gene gun inoculation of plasmid DNA expressing the prM and E genes of either Russian spring summer encephalitis virus or Central European encephalitis virus. Here, the vaccines were evaluated in rhesus macaques (Macaca mulatta) and the results compared with those obtained with the Austrian commercial inactivated-virus vaccine. The results suggested that DNA vaccines may offer protective immunity to primates similar to that obtained with the inactivated-virus vaccine.