Invasive Species Compendium

Detailed coverage of invasive species threatening livelihoods and the environment worldwide

Abstract

Antimalarial activity of 20 crude extracts from nine African medicinal plants used in Kinshasa, Congo.

Abstract

Twenty extracts, 10 EtOH and 10 CH2Cl2, from different parts of 9 African medicinal plants used in Congolese traditional medicine for the treatment of malaria, were submitted to a pharmacological test in order to evaluate their effect on Plasmodium falciparum growth in vitro. Of these plant species, 14 (70%) extracts including EtOH and CH2Cl2 extracts of Cassia occidentalis leaves, Cryptolepis sanguinolenta root bark, Euphorbia hirta whole plant, Garcinia kola stem bark and seeds, Morinda lucida leaves and Phyllanthus niruri whole plant produced more than 60% inhibition of the parasite growth in vitro at a test concentration of 6 µg/ml. Extracts from E. hirta, C. sanguinolenta and M. morindoides showed a significant chemosuppression of parasitaemia in mice infected with P. berghei berghei at oral doses of 100-400 mg/kg per day.