Muscle degeneration in chicks caused by Senna occidentalis seeds.
Seven-day-old chicks were fed ground dried seeds of S. occidentalis mixed in feed at 4% for 15 days. Clinical signs included anorexia, emaciation and muscular weakness. Mortality was 57% by the end of the experiment. PM findings included paleness and atrophy of thoracic muscles. Skeletal muscle showed microscopic degenerative and necrotic fibres. Muscle histochemistry showed accumulation of lipids and numerous acid phosphatase-positive muscle fibres. Electron microscopy identified atrophic muscle fibres, lipid storage, dilatation of the sarcoplasmic reticulum and abnormal mitochondria.