Invasive Species Compendium

Detailed coverage of invasive species threatening livelihoods and the environment worldwide

Abstract

In vitro infection with Theileria parva is associated with IL10 expression in all bovine lymphocyte lineages.

Abstract

The patterns of cytokine mRNA expressed by 19 bulk and cloned Theileria parva-infected lymphoblast cell lines were investigated using a multiplex PCR system. Considerable variation was observed in the cytokine profiles of these lines and only IL-10 was universally expressed. Investigation of cloned lines representing the major bovine lymphocyte populations failed to reveal a lineage-specific pattern of cytokine mRNA expression that could be associated with infection. However, analysis of a CD4+ T cell clone before and after transformation with the parasite indicated that infection does alter the pattern of cytokine expression, with apparent upregulation of IL-10. It is suggested that IL-10 derived from infected cells may influence the immune responses of naive cattle to challenge.