Invasive Species Compendium

Detailed coverage of invasive species threatening livelihoods and the environment worldwide

Abstract

Antimalarial active principles of Spathodea campanulata stem bark.

Abstract

Antimalarial principles of an extract of stem bark of S. campanulata were isolated and characterized as 3β-hydroxyurs-12-en-28-oic acid (ursolic acid) and 2 of its derivatives: 3β-hydroxyurs-12,19-dien-28-oic acid (tomentosolic acid) and 3β,20β-dihydroxyurs-12-en-28-oic acid. The 3 compounds suppressed parasitaemia and prolonged survival times of mice infected with Plasmodium berghei berghei. This is the first report of the isolation of ursolic acid and its derivatives as antimalarial compounds.