Antiinflammatory effects of Moringa oleifera root extract.
M. oleifera is used in traditional medicine to treat inflammatory conditions. A crude methanol extract of roots of M. oleifera (collected from Nigeria) was screened for antiinflammatory properties using the rat paw oedema and the rat 6-day air pouch inflammatory models. The extract (p.o.) inhibited carrageenan-induced paw oedema in a dose-dependent manner (IC50 value of 660 mg/kg). In the 6-day air pouch acute inflammation model, the extract was much more potent (IC50 values of 302.0 and 315.5 mg/kg, for the inhibition of cellular accumulation and fluid exudation, respectively). The extract was less effective against delayed (chronic) inflammation induced in the 6-day air pouch model using Freund's complete adjuvant. A moderate dose of indomethacin [indometacin] (5 mg/kg) inhibited the acute, but not the delayed form of air pouch inflammation. Acute toxicity tests in mice suggested very low toxicity.