Invasive Species Compendium

Detailed coverage of invasive species threatening livelihoods and the environment worldwide

Abstract

Mode of action of active principles from stem bark of Albizzia lebbeck Benth.

Abstract

Antimicrobial screening of active principle(s) isolated from stem bark of Albizzia lebbeck [Albizia lebbeck] (a species used in the Ayurvedic system of medicine) showed that the total glycosides, cardenolide glycosides and anthraquinone glycosides/anthraquinones were active against the test cultures selected for study. Study of the mode of action of the active principles against aerobes showed that the glycosides caused leakage of cytoplasmic constituents. Electron micrographs of Staphylococcus aureus cells treated with the minimum inhibitory concentration of anthraquinones revealed coarse granulation of the cytoplasmic matrix, vacuolation of the cells, and in a few cases, disruption of the cell surface.