Diuretic action of an aqueous extract of Lepidium latifolium L.
L. latifolium is used medicinally in the Canary Islands, Spain, as a diuretic and stomachic tonic. Results of a pharmacological screening study for the diuretic activity in female Wistar rats are presented and discussed. Compared with untreated rats, aqueous L. latifolium leaf extracts given orally and intraperitoneally enhanced urinary excretion. A slight increase in ion excretion was also observed. Attempts to extrapolate the diuretic action of L. latifolium extracts from rat to man led to the recommended daily dose of 3-5 g L. latifolium extract per man per day, administered as tea. The conclusions are that L. latifolium leaf extracts have diuretic and possibly also hypotensive properties.