Invasive Species Compendium

Detailed coverage of invasive species threatening livelihoods and the environment worldwide

Abstract

Swaledale sheep affected by natural scrapie differ significantly in PrP genotype frequencies from healthy sheep and those selected for reduced incidence of scrapie.

Abstract

PrP glycoprotein gene polymorphisms were examined in 53 Swaledale sheep affected by natural scrapie, in 84 healthy sheep and in 143 Swaledales selected for low susceptibility to scrapie. The three groups differed in frequencies of PrP genotypes detected by the restriction enzymes EcoRI, HindIII and BspHI, the latter being indicative of PrP protein amino acid difference at codon 136. These frequencies were confirmed in a single-flock study and present good evidence that scrapie susceptibility and resistance are associated with PrP gene variants in Swaledale sheep.