Antimalarial experimental chemotherapy using natural products. I. A more rational approach?
A total of 148 Brazilian plants, mostly in the form of crude extracts, from 38 families, were tested for antimalarial activity against Plasmodium berghei in mice. All were inactive at 100 mg/kg (4 oral doses), including one isolated from Ampelozizythus amazonicus (Rhamnaceae), known in Amazonian fokelore as a potent antimalarial. It is suggested that an empirical approach to the search for natural product extracts against malaria and other parasitic diseases should be replaced by more rational testing, based on popular fokelore.