Canine distemper virus in domesticated cats and pigs.
Twenty-two cats and 17 pigs ranging in age from 2 days to 2 years were found to be susceptible to intranasal inoculation of virulent canine distemper (CD) virus. Virus replicated in lymphatic tissues and in macrophages, but not in surface epithelium or brain. Infection in cats and pigs was inapparent. Pathologic changes were mild and were restricted to lymphatic tissue and lungs. Intracerebral inoculation did not result in clinical signs or pathologic changes in the brain. Virus spread from infected dogs to cats, but not from infected cats to dogs, cats to cats, or pigs to pigs. Serum samples from 14 of 150 cats had neutralizing antibody to CD virus.