Herein, we offer a facile synthesis of three novel conformers (cone, partial cone, and 1,3-alternate) of thiacalix[4]arene derivatives, comprising 5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrakis{2-oxo-2-[(dimethylamino-methylidene)hydrazino]ethoxy}-2,8,14,20-tetrathiacalix[4]arene, 3a-c via the...

Introduction: Mono-(2-ethylhexyl) phthalate (MEHP) represents a toxicological risk for marine organisms due to its widespread presence in aquatic environments. Methods. MEHP effects on cell viability, cell death and genotoxicity were investigated on the DLEC cell line, derived from early embryos of ...

Assessing the ecotoxicological risk of marine sediments is now a critical factor in deciding how to treat dredged material in harbor and coastal areas. Although ecotoxicological analyses are routinely required by some regulatory agencies in Europe, laboratory skills necessary to perform them are...

In view of the issues of dietary risk assessment of pesticide residues in foods in China, discussion of the following aspects of related concerns were conducted. First, the relevance and the scientific justifications of conducting risk assessment of pesticide residues in foods. Second, the way of...

Current studies on abiotic impacts on Artemia, a crustacean which is widely used in aquaculture, and ecotoxicology, often focus on endpoint analysis (e.g., hatching rates, survival). Here, we demonstrate that a mechanistic understanding can be obtained through measurement of oxygen consumption in...

Organosilicone tank-mixed adjuvants are a class of pesticide adjuvants widely used in agriculture with excellent wettability, penetrability, and spreadability. They show significant synergies and effectively improve the utilization rate of pesticides after spraying with pesticides. However, a large ...

Traditional herbal medicinal products (THMP) with Thymi herba are very popular as OTC among the European population. The aim of this article was the toxicological risk assessment (TRA) of Cd impurities in THMP with Thymi herba from Polish pharmacies. The estimations of Cd impurities in the single...

Strategies to estimate the risks from dietary exposure to multiple pesticides have been developed since the 1980s, based on the dose-addition of substances within a mixture with similar biological activity that differ in their potencies. In this paper, the different strategies to estimate the...

The criteria for the application of hazard property code HP14 "ecotoxicity" to waste assessment have been defined by the Council Regulation (EU) 2017/997. However, on the basis of available methodologies, its application may present some issues. Those can be referred to the preparation and...

Human diseases and health concerns caused by environmental pollutants are globally emerging. Therefore, rapid and efficient evaluation of the effects of environmental pollutants on human health is essential. Due to the significant differences between humans and animals and the lack of...