This chapter presents published research data on the antibiotic susceptibility of Borrelia burgdorferi sensu lato (Bbsl), and discusses the current practice for treating incubating Bbsl infection (chemoprophylaxis) and localized infection. Clinical data on the efficacy of oral doxycycline for...

This chapter provides a European perspective on the epidemiology of Lyme neuroborreliosis, highlighting the prevailing genospecies of Borrelia burgdorferi sensu lato, main vector (Ixodes ricinus), and geographical variation in incidence. It then discusses the European Federation of Neurological...

Erythema migrans (EM) is an expanding erythematous rash that develops at the site of the bite of certain Ixodes ticks within days to weeks. It is the most common objective manifestation of Lyme disease, accounting for about 90% of cases. This chapter reviews the current practice of diagnosing EM,...

The cardiac complications of Lyme disease (termed Lyme carditis) present during the early disseminated phase of infection by Borrelia burgdorferi, usually 3 weeks to 3 months after initial inoculation. The clinical manifestations of Lyme carditis are typically self-limited and almost always involve ...

This chapter is divided into 3 sections. The first section describes the musculoskeletal consequences of Lyme disease, including: arthralgia, migratory polyarthralgia and myalgias; monoarthritis and oligoarthritis; patellofemoral joint dysfunction; persisting musculoskeletal pain after antibiotic...

This chapter reviews basic pathological concepts of nervous system disease, followed by an examination of the pathogenesis of neuroborreliosis and the clinical manifestations of central nervous system and peripheral nerve involvement. It also describes the disorder termed Lyme disease...

This chapter reviews the aetiology, epidemiology, clinical manifestations, diagnosis, treatment, post-treatment prognosis, and prevention of Lyme disease in children. It also briefly discusses "misguided" beliefs about "chronic" Lyme disease, and how clinicians should address them.

Previous studies have shown that there are Lyme disease patients who after treatment with proper antibiotic regimens had developed post-antibiotic therapy symptoms that they and their doctors attributed to Lyme disease. The ongoing controversy over a diagnosis many think does not actually exist...

Despite being widely used by both the lay and medical communities, chronic Lyme disease (CLD) is a very complicated term, used as a label for quite different patient groups. These include patients with late Lyme disease (e.g. arthritis and late neuroborreliosis), as well as patients described as...

This chapter traces the origin of the clinical condition termed 'chronic Lyme disease' (CLD) and explores the various medical, political, and legal issues it has brought. It also provides a detailed examination of some of the key myths that together reinforced the recognition of CLD as a diagnosis. ...