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CABI Book Chapter

Lyme disease: an evidence-based approach.

Book cover for Lyme disease: an evidence-based approach.

Description

This second edition provides up-to-date evidence-based research and covers the significant advances in our understanding of the disorders referred to as Lyme disease or Lyme borreliosis. Consisting of 17 chapters, this book explores the causative organism, its requisite ecosystem, disease epidemiology, host-Borrelia interactions, diagnostic testing, clinical manifestations, therapeutic options, th...

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Chapter 10 (Page no: 142)

Erythema migrans.

Erythema migrans (EM) is an expanding erythematous rash that develops at the site of the bite of certain Ixodes ticks within days to weeks. It is the most common objective manifestation of Lyme disease, accounting for about 90% of cases. This chapter reviews the current practice of diagnosing EM, and presents epidemiological data on the frequency of EM in patients with Lyme disease. It describes the physical characteristics of EM, as well as the commonly associated systemic symptoms and physical findings, and then discusses the influence of subtypes of Borrelia burgdorferi sensu stricto on clinical manifestations. The challenges of differentiating Lyme disease-related EM from hypersensitivity reaction to an arthropod bite or from southern tick-associated rash infection, are examined. The long-term outcome of Lyme disease cases after antibiotic treatment is discussed, with special reference to pregnant and immunocompromised patients. Published research data on the incidence of repeat episodes of EM as a result of reinfection are also summarized.

Other chapters from this book

Chapter: 1 (Page no: 1) Ticks: the vectors of Lyme disease. Author(s): Smith, R. P.
Chapter: 2 (Page no: 29) Biology of the Lyme disease agents: a selective survey of clinical and epidemiologic relevance. Author(s): Barbour, A. G.
Chapter: 3 (Page no: 45) Borreliella: interactions with the host immune system. Author(s): Sperber, K. Dattwyler, R. J.
Chapter: 4 (Page no: 58) Diagnostic testing for Lyme disease. Author(s): Auwaerter, P. G.
Chapter: 5 (Page no: 76) Global epidemiology of Borreliella burgdorferi infections. Author(s): Mead, P. S.
Chapter: 6 (Page no: 93) Antibiotic therapy for infection caused by Borrelia burgdorferi sensu lato. Author(s): Wormser, G. P.
Chapter: 7 (Page no: 105) Lyme borreliosis: the European perspective. Author(s): Strle, F. Stanek, G. Strle, K.
Chapter: 8 (Page no: 124) Lyme neuroborreliosis: a European perspective. Author(s): Dersch, R.
Chapter: 9 (Page no: 139) Medically unexplained symptoms and Lyme neuroborreliosis - not the same: a study in an endemic area of Norway. Author(s): Roaldsnes, E. Eikeland, R. Berild, D.
Chapter: 11 (Page no: 168) Lyme carditis. Author(s): Salik, J. R. Dudzinski, D. M.
Chapter: 12 (Page no: 180) The musculoskeletal manifestations of Lyme disease (infection with Borrelia burgdorferi). Author(s): Sigal, L. H.
Chapter: 13 (Page no: 202) Nervous system involvement. Author(s): Halperin, J. J.
Chapter: 14 (Page no: 216) Lyme disease in children. Author(s): Shapiro, E. D.
Chapter: 15 (Page no: 227) The psychology of 'post-Lyme disease syndrome' and 'not Lyme'. Author(s): Hassett, A. L. Sigal, L. H.
Chapter: 16 (Page no: 247) Chronic Lyme disease. Author(s): Marques, A.
Chapter: 17 (Page no: 262) Lyme disease: the great controversy. Author(s): Halperin, J. J. Baker, P. Wormser, G. P.