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CABI Book Chapter

Lyme disease: an evidence-based approach.

Book cover for Lyme disease: an evidence-based approach.

Description

This second edition provides up-to-date evidence-based research and covers the significant advances in our understanding of the disorders referred to as Lyme disease or Lyme borreliosis. Consisting of 17 chapters, this book explores the causative organism, its requisite ecosystem, disease epidemiology, host-Borrelia interactions, diagnostic testing, clinical manifestations, therapeutic options, th...

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Chapter 3 (Page no: 45)

Borreliella: interactions with the host immune system.

This chapter briefly reviews the interaction of Borrelia burgdorferi sensu lato (Bb) with the host immune system, and provides an update regarding how this relates to newer humoral and cellular diagnostic assays. Bb has complex interactions with its host, allowing it to evade detection and destruction by both the humoral and cellular components of the immune system. The anti-Bb response can be exploited to develop new and more accurate diagnostic testing allowing for earlier treatment of this infection. The evaluation of novel diagnostic markers on a multiplex antigen panel and in a T cell proliferative assay aimed at improving the immunologic detection of Bb in early Lyme disease (LD) patients provides a foundation for the development of the next generation of assays for the laboratory diagnosis of LD.

Other chapters from this book

Chapter: 1 (Page no: 1) Ticks: the vectors of Lyme disease. Author(s): Smith, R. P.
Chapter: 2 (Page no: 29) Biology of the Lyme disease agents: a selective survey of clinical and epidemiologic relevance. Author(s): Barbour, A. G.
Chapter: 4 (Page no: 58) Diagnostic testing for Lyme disease. Author(s): Auwaerter, P. G.
Chapter: 5 (Page no: 76) Global epidemiology of Borreliella burgdorferi infections. Author(s): Mead, P. S.
Chapter: 6 (Page no: 93) Antibiotic therapy for infection caused by Borrelia burgdorferi sensu lato. Author(s): Wormser, G. P.
Chapter: 7 (Page no: 105) Lyme borreliosis: the European perspective. Author(s): Strle, F. Stanek, G. Strle, K.
Chapter: 8 (Page no: 124) Lyme neuroborreliosis: a European perspective. Author(s): Dersch, R.
Chapter: 9 (Page no: 139) Medically unexplained symptoms and Lyme neuroborreliosis - not the same: a study in an endemic area of Norway. Author(s): Roaldsnes, E. Eikeland, R. Berild, D.
Chapter: 10 (Page no: 142) Erythema migrans. Author(s): Nadelman, R. B. Hu, L.
Chapter: 11 (Page no: 168) Lyme carditis. Author(s): Salik, J. R. Dudzinski, D. M.
Chapter: 12 (Page no: 180) The musculoskeletal manifestations of Lyme disease (infection with Borrelia burgdorferi). Author(s): Sigal, L. H.
Chapter: 13 (Page no: 202) Nervous system involvement. Author(s): Halperin, J. J.
Chapter: 14 (Page no: 216) Lyme disease in children. Author(s): Shapiro, E. D.
Chapter: 15 (Page no: 227) The psychology of 'post-Lyme disease syndrome' and 'not Lyme'. Author(s): Hassett, A. L. Sigal, L. H.
Chapter: 16 (Page no: 247) Chronic Lyme disease. Author(s): Marques, A.
Chapter: 17 (Page no: 262) Lyme disease: the great controversy. Author(s): Halperin, J. J. Baker, P. Wormser, G. P.