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CABI Book Chapter

Bovine tuberculosis.

Book cover for Bovine tuberculosis.


This 269-paged book on Bovine Tubeculosis covers all aspects of Mycobacterium bovis biology and infection: epidemiological, pathological, microbiological, genomic and immunological together with a comparative approach to the different control schemes being undertaken in different countries. It has 16 chapters that focused on the following (chapters 1-16): Bovine Tuberculosis: worldwide picture; My...


Chapter 12 (Page no: 173)

Immunological diagnosis.

This chapter discussed the pathogenesis of bovine tuberculosis (TB) and presents some of the advances that have been made in the discovery and development of antigens and immune biomarkers for potential use in the diagnosis of bovine tuberculosis and how some of these antigens (e.g. ESAT-6, CFP10, Rv3615c, MPB83 and MPB70) and none of the biomarkers have been utilized even for limited use in commercial diagnostic tests. This chapter suggests the need for the next step in immune assay development by critically evaluating novel immune biomarkers/antigens in practical platforms with a wide range of samples from naturally infected cattle for direct comparison to existing official tests (in particular, traditional TST and IGRAs).

Other chapters from this book

Chapter: 1 (Page no: 1) Bovine tuberculosis: worldwide picture. Author(s): Awada, L. Tizzani, P. Erlacher-Vindel, E. Forcella, S. Caceres, P.
Chapter: 2 (Page no: 16) Mycobacterium bovis as the causal agent of human tuberculosis: public health implications. Author(s): Olea-Popelka, F. Dean, A. S. Muwonge, A. Perera, A. Raviglione, M. Fujiwara, P. I.
Chapter: 3 (Page no: 31) Economics of bovine tuberculosis: a one health issue. Author(s): Azami, H. Y. Zinsstag, J.
Chapter: 4 (Page no: 43) The epidemiology of Mycobacterium bovis infection in cattle. Author(s): Conlan, A. J. K. Wood, J. L. N.
Chapter: 5 (Page no: 58) Mycobacterium bovis molecular typing and surveillance. Author(s): Skuce, R. A. Byrne, A. W. Lahuerta-Marin, A. Allen, A.
Chapter: 6 (Page no: 80) Bovine tuberculosis in other domestic species. Author(s): Michel, A. L.
Chapter: 7 (Page no: 93) Role of wildlife in the epidemiology of Mycobacterium bovis. Author(s): Fox, N. J. Barrow, P. A. Hutchings, M. R.
Chapter: 8 (Page no: 106) Molecular virulence mechanisms of Mycobacterium bovis. Author(s): Smyth, A. Gordon, S. V.
Chapter: 9 (Page no: 122) The pathology and pathogenesis of Mycobacterium bovis infection. Author(s): Salguero, F. J.
Chapter: 10 (Page no: 140) Innate immune response in bovine tuberculosis. Author(s): Carrisoza-Urbina, J. Zhou XiangMei Gutiérrez-Pabello, J. A.
Chapter: 11 (Page no: 154) Adaptive immunity. Author(s): Hope, J. Werling, D.
Chapter: 13 (Page no: 191) Biomarkers in the diagnosis of Mycobacterium tuberculosis complex infections. Author(s): Wanzala, S. I. Srinand Sreevatsan
Chapter: 14 (Page no: 206) Vaccination of domestic and wild animals against tuberculosis. Author(s): Buddle, B. M. Parlane, N. A. Chambers, M. A. Gortázar, C.
Chapter: 15 (Page no: 225) Managing bovine tuberculosis: successes and issues. Author(s): Livingstone, P. Hancox, N.
Chapter: 16 (Page no: 248) Perspectives on global bovine tuberculosis control. Author(s): Olea-Popelka, F. Chambers, M. A. Gordon, S. Barrow, P.

Chapter details

  • Author Affiliation
  • National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, Iowa, USA.
  • Year of Publication
  • 2018
  • ISBN
  • 9781786391520
  • Record Number
  • 20183117969