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Mononegaviruses of veterinary importance. Volume 2: molecular epidemiology and control.

Book cover for Mononegaviruses of veterinary importance. Volume 2: molecular epidemiology and control.


This book "Mononegaviruses of Veterinary Importance", Volume 2 complements the first volume "Mononegaviruses of Veterinary Importance: Pathobiology and Molecular Diagnosis". This book discusses the epidemiology and control of Mononegaviruses that pose a significant threat to animals in terms of severity and epidemiological risk. It also addresses viruses with zoonotic potential, and many that can ...


Chapter 10 (Page no: 127)

Avian metapneumovirus.

Avian metapneumovirus (aMPV) is the type species of the genus Metapneumovirus in the subfamily Pneumovirinae within the family Paramyxoviridae. The genome encodes eight discrete transcription units, which are generally assumed to code for nine proteins. Genes are flanked by a 3′ leader and 5′ trailer in the order 3′-N (nucleocapsid)-P (phosphoprotein)-M (matrix)-F (fusion)-M2 (second matrix)-SH (small hydrophobic)-G (glycoprotein)-L (large polymerase)-5′. Virions are pleomorphic, with sizes ranging from 50 nm to more than 200 nm. Based on the level of genetic variation and antigenic difference, aMPV isolates have been classified into four distinct subtypes: A, B, C and D. Turkeys and chickens are the most susceptible species and show an upper respiratory disease and reproductive disorders when infected. Pheasants, guinea fowls and ducks can also be affected and develop clinical disease. Since its first appearance in South Africa in the late 1970s, aMPV has been reported worldwide. The main approach to control of aMPV is by the use of live attenuated and inactivated vaccines. Several research groups have attempted development of a novel generation of vaccines, but for each of these approaches protection has been inferior to that afforded by live vaccines.

Other chapters from this book

Chapter: 1 (Page no: 1) Bornaviruses. Author(s): Kinnunen, P. M. Wensman, J. J.
Chapter: 2 (Page no: 15) Newcastle disease virus. Author(s): Munir, M.
Chapter: 3 (Page no: 41) Hendra and Nipah viruses. Author(s): Clayton, B. A. Smith, I. L. Marsh, G. A.
Chapter: 4 (Page no: 58) Canine distemper virus. Author(s): Techangamsuwan, S. Pratakpiriya, W.
Chapter: 5 (Page no: 71) Peste des petits ruminants virus. Author(s): Shabbir, M. Z. Munir, M.
Chapter: 6 (Page no: 81) Contribution of epidemiological knowledge and control strategies in the eradication of rinderpest virus. Author(s): Brüning-Richardson, A. Parida, S. Banyard, A. C.
Chapter: 7 (Page no: 98) Bovine parainfluenza virus type 3. Author(s): Spilki, F. R.
Chapter: 8 (Page no: 106) Porcine rubulavirus. Author(s): Berg, M. Cuevas-Romero, S. Moreno-López, J.
Chapter: 9 (Page no: 114) Bovine respiratory syncytial virus. Author(s): Dus Santos, M. J. Mozgovoj, M.
Chapter: 11 (Page no: 144) Rabies virus. Author(s): Brandão, P. E.
Chapter: 12 (Page no: 156) Filoviruses. Author(s): Bradfute, S. B. Jahrling, P. B. Kuhn, J. H.
Chapter: 13 (Page no: 174) Sea mammal morbilliviruses. Author(s): Rubio-Guerri, C. Sánchez-Vizcaíno, J. M.
Chapter: 14 (Page no: 185) Infectious hematopoietic necrosis virus. Author(s): Dhar, A. K. Robles-Sikisaka, R. Orry, A. Allnutt, F. C. T.

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