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CABI Book Info

Antimicrobial drug discovery: emerging strategies.

Book cover for Antimicrobial drug discovery: emerging strategies.

Description

This book, inclusive of 22 chapters, describes novel approaches currently used for antimicrobial drug discovery, focusing on agents for use against bacterial and fungal pathogens. Specific chapters discuss: (1) concepts relevant to drug resistance; (2) microbial mechanisms related to efflux pumps and studies on their potential inhibitors; (3) impact of multidrug tolerance of biofilms and persister cells; (4) bacterial quorum-sensing inhibition; (5) inhibition of the bacterial filamentous temperature-sensitive mutant Z (FtsZ); (6) antibacterial properties of lysostaphin; (7) strategies to identify modified ribosomally synthesized antimicrobials; (8) quantitative structure-activity relationship studies of novel antimicrobial peptides; (9) bacterial acetyl-CoA carboxylase and lipopolysacharide as drug targets for antibiotic development; (10) pathosystematic systems biology for the rational design of novel antifungal compounds; (11) specific animal models for novel antimicrobial discovery; and (12) new antimicrobial technology platforms such as antimicrobial photodynamic therapy and carbon nanotubes.

Metrics

Book Chapters

Chapter: 1 (Page no: 1) Introduction. Author(s): Tegos, G. Mylonakis, E.
Chapter: 2 (Page no: 7) Emerging antimicrobial drug-discovery strategies: an evolving necessity. Author(s): Ball, A. R. Tegos, G. P.
Chapter: 3 (Page no: 26) The antibiotic crisis. Author(s): Demain, A. L. Spizek, J.
Chapter: 4 (Page no: 44) Structure, genetic regulation, physiology and function of the AcrAB-TolC efflux pump of Escherichia coli and Salmonella. Author(s): Amaral, L. Martins, A. Spengler, G. Martins, M. Rodrigues, L. McCusker, M. Ntokou, E. Cerca, P. Machado, L. Viveiros, M. Couto, I. Fanning, S. Kristiansen, J. Molnar, J.
Chapter: 5 (Page no: 62) Small-molecule efflux pump inhibitors from natural products as a potential source of antimicrobial agents. Author(s): Jachak, S. M. Roy, S. K. Shiv Gupta Pallavi Ahirrao Gibbons, S.
Chapter: 6 (Page no: 77) Fungal efflux-mediated resistance: from targets to inhibitors. Author(s): Monk, B. C. Niimi, K. Holmes, A. R. Strouse, J. J. Sklar, L. A. Cannon, R. D.
Chapter: 7 (Page no: 89) Vacuolar ATPase: a model proton pump for antifungal drug discovery. Author(s): Parra, K. J.
Chapter: 8 (Page no: 101) Drug tolerance, persister cells and drug discovery. Author(s): Lewis, K.
Chapter: 9 (Page no: 115) Inhibition of quorum sensing as a novel antimicrobial strategy. Author(s): Brackman, G. Nelis, H. J. Coenye, T.
Chapter: 10 (Page no: 135) Filamentous temperature-sensitive mutant Z (FtsZ) protein as an antibacterial target. Author(s): Boberek, J. M. Goh Shan Stach, J. Good, L.
Chapter: 11 (Page no: 147) Lysostaphin: a silver bullet for staph. Author(s): Kokai-Kun, J. F.
Chapter: 12 (Page no: 166) Strategies to identify modified ribosomally synthesized antimicrobials. Author(s): Marsh, A. J. Hill, C. Ross, R. P. Cotter, P. D.
Chapter: 13 (Page no: 187) Quantitative structure - activity relationship-based discovery of antimicrobial peptides active against multidrug-resistant bacteria. Author(s): Fjell, C. D. Jenssen, H. Hancock, R. E. W. Cherkasov, A.
Chapter: 14 (Page no: 208) Acetyl-CoA carboxylase as a target for antibacterial development. Author(s): Waldrop, G. L.
Chapter: 15 (Page no: 220) Underexploited targets in lipopolysaccharide biogenesis for the design of antibacterials. Author(s): Cipolla, L. Gabrielli, L. Bini, D. Russo, L.
Chapter: 16 (Page no: 232) Predicting and dissecting high-order molecular complexity by information-driven biomolecular docking. Author(s): Kastritis, P. L. Bonvin, A. M. J. J.
Chapter: 17 (Page no: 247) Antifungals and antifungal drug discovery. Author(s): Calderone, R. Fonzi, W. Gay-Andrieu, F. Sun, N. Li, D. M. Chen, H. Alex, D.
Chapter: 18 (Page no: 265) Pathosystematic studies and the rational design of antifungal interventions. Author(s): Bignell, E. M. Armstrong-James, D.
Chapter: 19 (Page no: 292) In vivo high-throughput antimicrobial discovery screens utilizing Caenorhabditis elegans as an alternative host. Author(s): Coleman, J. J. Mylonakis, E.
Chapter: 20 (Page no: 300) Drosophila melanogaster as a versatile model for the discovery of drugs effective against human microbe-induced infection and pathology. Author(s): Apidianakis, Y. Kontoyiannis, D. P.
Chapter: 21 (Page no: 310) Antimicrobial photosensitizers: harnessing the power of light to treat infections. Author(s): Sharma, S. K. Dai, T. H. Hamblin, M. R.
Chapter: 22 (Page no: 323) Nanoparticle platforms for antimicrobial therapy. Author(s): Trofa, D. Nosanchuk, J. D.
Chapter: 23 (Page no: 338) Antimicrobial activity of carbon nanotubes. Author(s): Liu ShaoBin Chen Yuan