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CABI Book Info

Antimicrobial drug discovery: emerging strategies.

Book cover for Antimicrobial drug discovery: emerging strategies.


This book, inclusive of 22 chapters, describes novel approaches currently used for antimicrobial drug discovery, focusing on agents for use against bacterial and fungal pathogens. Specific chapters discuss: (1) concepts relevant to drug resistance; (2) microbial mechanisms related to efflux pumps and studies on their potential inhibitors; (3) impact of multidrug tolerance of biofilms and persister cells; (4) bacterial quorum-sensing inhibition; (5) inhibition of the bacterial filamentous temperature-sensitive mutant Z (FtsZ); (6) antibacterial properties of lysostaphin; (7) strategies to identify modified ribosomally synthesized antimicrobials; (8) quantitative structure-activity relationship studies of novel antimicrobial peptides; (9) bacterial acetyl-CoA carboxylase and lipopolysacharide as drug targets for antibiotic development; (10) pathosystematic systems biology for the rational design of novel antifungal compounds; (11) specific animal models for novel antimicrobial discovery; and (12) new antimicrobial technology platforms such as antimicrobial photodynamic therapy and carbon nanotubes.


Book Chapters

Chapter: 1 (Page no: 1) Introduction. Author(s): Tegos, G. Mylonakis, E.
Chapter: 2 (Page no: 7) Emerging antimicrobial drug-discovery strategies: an evolving necessity. Author(s): Ball, A. R. Tegos, G. P.
Chapter: 3 (Page no: 26) The antibiotic crisis. Author(s): Demain, A. L. Spizek, J.
Chapter: 4 (Page no: 44) Structure, genetic regulation, physiology and function of the AcrAB-TolC efflux pump of Escherichia coli and Salmonella. Author(s): Amaral, L. Martins, A. Spengler, G. Martins, M. Rodrigues, L. McCusker, M. Ntokou, E. Cerca, P. Machado, L. Viveiros, M. Couto, I. Fanning, S. Kristiansen, J. Molnar, J.
Chapter: 5 (Page no: 62) Small-molecule efflux pump inhibitors from natural products as a potential source of antimicrobial agents. Author(s): Jachak, S. M. Roy, S. K. Shiv Gupta Pallavi Ahirrao Gibbons, S.
Chapter: 6 (Page no: 77) Fungal efflux-mediated resistance: from targets to inhibitors. Author(s): Monk, B. C. Niimi, K. Holmes, A. R. Strouse, J. J. Sklar, L. A. Cannon, R. D.
Chapter: 7 (Page no: 89) Vacuolar ATPase: a model proton pump for antifungal drug discovery. Author(s): Parra, K. J.
Chapter: 8 (Page no: 101) Drug tolerance, persister cells and drug discovery. Author(s): Lewis, K.
Chapter: 9 (Page no: 115) Inhibition of quorum sensing as a novel antimicrobial strategy. Author(s): Brackman, G. Nelis, H. J. Coenye, T.
Chapter: 10 (Page no: 135) Filamentous temperature-sensitive mutant Z (FtsZ) protein as an antibacterial target. Author(s): Boberek, J. M. Goh Shan Stach, J. Good, L.
Chapter: 11 (Page no: 147) Lysostaphin: a silver bullet for staph. Author(s): Kokai-Kun, J. F.
Chapter: 12 (Page no: 166) Strategies to identify modified ribosomally synthesized antimicrobials. Author(s): Marsh, A. J. Hill, C. Ross, R. P. Cotter, P. D.
Chapter: 13 (Page no: 187) Quantitative structure - activity relationship-based discovery of antimicrobial peptides active against multidrug-resistant bacteria. Author(s): Fjell, C. D. Jenssen, H. Hancock, R. E. W. Cherkasov, A.
Chapter: 14 (Page no: 208) Acetyl-CoA carboxylase as a target for antibacterial development. Author(s): Waldrop, G. L.
Chapter: 15 (Page no: 220) Underexploited targets in lipopolysaccharide biogenesis for the design of antibacterials. Author(s): Cipolla, L. Gabrielli, L. Bini, D. Russo, L.
Chapter: 16 (Page no: 232) Predicting and dissecting high-order molecular complexity by information-driven biomolecular docking. Author(s): Kastritis, P. L. Bonvin, A. M. J. J.
Chapter: 17 (Page no: 247) Antifungals and antifungal drug discovery. Author(s): Calderone, R. Fonzi, W. Gay-Andrieu, F. Sun, N. Li, D. M. Chen, H. Alex, D.
Chapter: 18 (Page no: 265) Pathosystematic studies and the rational design of antifungal interventions. Author(s): Bignell, E. M. Armstrong-James, D.
Chapter: 19 (Page no: 292) In vivo high-throughput antimicrobial discovery screens utilizing Caenorhabditis elegans as an alternative host. Author(s): Coleman, J. J. Mylonakis, E.
Chapter: 20 (Page no: 300) Drosophila melanogaster as a versatile model for the discovery of drugs effective against human microbe-induced infection and pathology. Author(s): Apidianakis, Y. Kontoyiannis, D. P.
Chapter: 21 (Page no: 310) Antimicrobial photosensitizers: harnessing the power of light to treat infections. Author(s): Sharma, S. K. Dai, T. H. Hamblin, M. R.
Chapter: 22 (Page no: 323) Nanoparticle platforms for antimicrobial therapy. Author(s): Trofa, D. Nosanchuk, J. D.
Chapter: 23 (Page no: 338) Antimicrobial activity of carbon nanotubes. Author(s): Liu ShaoBin Chen Yuan