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CABI Book Chapter

Antimicrobial peptides: discovery, design and novel therapeutic strategies.

Book cover for Antimicrobial peptides: discovery, design and novel therapeutic strategies.

Description

The purpose of this book is to provide a comprehensive account on current antimicrobial peptide research in two major directions. The first direction delineates the classic path for peptide development, ranging through identification, design, structure and mode of action studies. The second direction describes novel strategies for developing peptide therapeutics based on our knowledge of host defe...

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Chapter 12 (Page no: 195)

Fine tuning host responses in the face of infection: emerging roles and clinical applications of host defence peptides.

Host defence peptides (HDPs) are powerful modulators of human innate immunity, and can modify the outcome of the endogenous host response to infection. The progressive development of pathogen resistance to conventional antimicrobial agents has lead to a new appreciation of HDPs for their ability to fight infection, enhance vaccine responses, limit infl ammation and promote wound healing, within the context of human disease. HDPs are a family of cationic, short, amphipathic peptides that include the classical mammalian antimicrobial peptides, cathelicidins and defensins, as well as non-antimicrobial peptides with similar immunomodulatory properties. This chapter reviews our current basic understanding of the anti-infective and immunomodulatory properties of both endogenous HDPs and synthetic derivatives (termed innate defence regulators) with regard to their ability to selectively fine tune the responses of host cells and physiology. The clinical application of these molecules is also discussed, with a focus on past and ongoing clinical trials of HDPs and innate defence regulators as novel therapeutics for infectious and infl ammatory diseases.

Other chapters from this book

Chapter: 1 (Page no: 1) A database view of naturally occurring antimicrobial peptides: nomenclature, classification and amino acid sequence analysis. Author(s): Wang, G. S. Li, X. Zasloff, M.
Chapter: 2 (Page no: 22) Lantibiotic-related research and the application thereof. Author(s): Healy, B. O'Mahony, J. Hill, C. Cotter, P. D. Ross, R. P.
Chapter: 3 (Page no: 40) Antimicrobial peptides in plants. Author(s): Kaas, Q. Westermann, J. C. Henriques, S. T. Craik, D. J.
Chapter: 4 (Page no: 72) Database-aided prediction and design of novel antimicrobial peptides. Author(s): Wang, G. S.
Chapter: 5 (Page no: 87) Discovery of novel antimicrobial peptides using combinatorial chemistry and high-throughput screening. Author(s): Wimley, W. C.
Chapter: 6 (Page no: 100) Chemical mimics with systemic efficacy. Author(s): Mor, A.
Chapter: 7 (Page no: 116) Biophysical analysis of membrane-targeting antimicrobial peptides: membrane properties and the design of peptides specifically targeting Gram-negative bacteria. Author(s): Epand, R. M. Epand, R. F.
Chapter: 8 (Page no: 128) Non-membrane targets of antimicrobial peptides: novel therapeutic opportunities? Author(s): Cho JuHyun Kim SunChang
Chapter: 9 (Page no: 141) Structural studies of antimicrobial peptides provide insight into their mechanisms of action. Author(s): Wang, G. S.
Chapter: 10 (Page no: 169) Lung infection: shifting the equilibrium towards the free and active form of human LL-37 and the design of alternative antimicrobial agents. Author(s): Janmey, P. A. Bucki, R.
Chapter: 11 (Page no: 181) Role of vitamin D in the enhancement of antimicrobial peptide gene expression. Author(s): White, J. H. Bitton, A. J.

Chapter details

  • Author Affiliation
  • Centre for Microbial Diseases and Immunity Research, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
  • Year of Publication
  • 2010
  • ISBN
  • 9781845936570
  • Record Number
  • 20103329302