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CABI Book Chapter

Quantitative trait loci analysis in animals.

Book cover for Quantitative trait loci analysis in animals.

Description

This book aims to summarize the scientific literature on methods for quantitative trait loci (QTL) detection and analysis and marker assisted selection (MAS), especially that pertaining to agricultural animal species, emphasizing the special problems associated with animal breeding. The 17 chapters cover the history of QTL and MAS estimation, principles of parameter estimation, mixed model analysi...

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Chapter 10 (Page no: 145)

Fine mapping of QTL.

This chapter explains the relationship between sample size and the critical interval for the location of a Mendelian gene with complete heritability, presents methods to compute the minimum confidence interval (CI) for QTL location with a saturated genetic map, methods to reduce the QTL location CI for crosses between inbred lines (advanced intercross lines (AIL), selective phenotyping, recombinant progeny testing, interval-specific congenic straits and recombinant inbred segregation test), methods for fine mapping of QTL in segregating populations and linkage disequilibrium QTL mapping.

Other chapters from this book

Chapter: 1 (Page no: 1) Historical overview. Author(s): Weller, J. I.
Chapter: 2 (Page no: 11) Principles of parameter estimation. Author(s): Weller, J. I.
Chapter: 3 (Page no: 24) Random and fixed effects, the mixed model. Author(s): Weller, J. I.
Chapter: 4 (Page no: 39) Experimental designs to detect QTL: generation of linkage disequilibrium. Author(s): Weller, J. I.
Chapter: 5 (Page no: 63) QTL parameter estimation for crosses between inbred lines. Author(s): Weller, J. I.
Chapter: 6 (Page no: 80) Advanced statistical methods for QTL detection and parameter estimation. Author(s): Weller, J. I.
Chapter: 7 (Page no: 103) Analysis of QTL as random effects. Author(s): Weller, J. I.
Chapter: 8 (Page no: 122) Statistical power to detect QTL, and parameter confidence intervals. Author(s): Weller, J. I.
Chapter: 9 (Page no: 135) Optimization of experimental designs. Author(s): Weller, J. I.
Chapter: 11 (Page no: 159) Complete genome QTL scans: the problem of multiple comparisons. Author(s): Weller, J. I.
Chapter: 12 (Page no: 173) Multitrait QTL analysis. Author(s): Weller, J. I.
Chapter: 13 (Page no: 186) From the QTL to the gene. Author(s): Weller, J. I.
Chapter: 14 (Page no: 194) Principles of selection index and traditional breeding programmes. Author(s): Weller, J. I.
Chapter: 15 (Page no: 204) Marker-assisted selection: theory. Author(s): Weller, J. I.
Chapter: 16 (Page no: 216) Marker-assisted selection: current status and results of simulation studies. Author(s): Weller, J. I.
Chapter: 17 (Page no: 232) Marker-assisted introgression. Author(s): Weller, J. I.