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Fetal nutrition and adult disease: programming of chronic disease through fetal exposure to undernutrition.

Book cover for Fetal nutrition and adult disease: programming of chronic disease through fetal exposure to undernutrition.


This book aims to paint a broad picture of current understanding of fetal programming. The volume presents a range of epidemiological data demonstrating links between events in fetal life and the development of cardiovascular disease, non-insulin-dependent diabetes, obesity and disorders of the immune system. The book is divided into three parts: programming the fetus (Part I), programming human disease (part II) and biological basis of nutritional programming (part III). Part I sets out the basic principles of programming and considers the potential contribution of undernutrition and other insults during critical phases of embryonic and fetal development, to abnormal physiology and disease processes in later life. Part II provides the core of the book and shows how suggestive epidemiological evidence for an association between characteristics at birth and later disease is replicated in experimental model. This part presents data that question the birthweight-disease association, highlighting the importance of well-designed experimental studies. The final part of the book sets out current ideas about the interrelationships of maternal nutrition, placental function and fetal endocrinology and looks at how early nutrient-gene interactions may exert permanent influences on health and well-being of an individual.


Book Chapters

Chapter: 1 (Page no: 1) Fetal programming of adult disease: an overview. Author(s): Langley-Evans, S. C.
Chapter: 2 (Page no: 21) Nutritional basis for the fetal origins of adult disease. Author(s): Harding, J.
Chapter: 3 (Page no: 55) Intrauterine hypoxaemia and cardiovascular development. Author(s): Giussani, D. A. Gardner, D. S.
Chapter: 4 (Page no: 87) Epidemiology of the fetal origins of adult disease: cohort studies of birthweight and cardiovascular disease. Author(s): Rich-Edwards, J.
Chapter: 5 (Page no: 105) Early-life origins of adult disease: is there really an association between birthweight and chronic disease risk? Author(s): Huxley, R.
Chapter: 6 (Page no: 129) Experimental models of hypertension and cardiovascular disease. Author(s): Langley-Evans, S. C.
Chapter: 7 (Page no: 157) Associations between fetal and infant growth and non-insulin-dependent diabetes. Author(s): Langley-Evans, S. C.
Chapter: 8 (Page no: 171) Programming of diabetes: experimental models. Author(s): Reusens, B. Kalbe, L. Remacle, C.
Chapter: 9 (Page no: 195) Birthweight and the development of overweight and obesity. Author(s): Stein, A. D.
Chapter: 10 (Page no: 211) Maternal nutrition in pregnancy and adiposity in offspring. Author(s): Breier, B. H. Krechowec, S. O. Vickers, M. H.
Chapter: 11 (Page no: 235) Renal disease and fetal undernutrition. Author(s): Woods, L. L.
Chapter: 12 (Page no: 259) Perinatal determinants of atopic disease. Author(s): Demissie, K. Chung, K. D. Balasubramanian, B. A.
Chapter: 13 (Page no: 311) Fetal programming of immune function. Author(s): McDade, T. W. Kuzawa, C. W.
Chapter: 14 (Page no: 333) Programming in the pre-implantation embryo. Author(s): Young, L. E. Rees, W. D. Sinclair, K. D.
Chapter: 15 (Page no: 353) Endocrine responses to fetal undernutrition: the growth hormone-insulin-like growth factor axis. Author(s): Symonds, M. E. Gardner, D. S. Pearce, S. Stephenson, T.
Chapter: 16 (Page no: 381) Impact of intrauterine exposure to glucocorticoids upon fetal development and adult pathophysiology. Author(s): Drake, A. J. Seckl, J. R.

Book details

  • Author Affiliation
  • Division of Nutritional Biochemistry, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK.
  • Year of Publication
  • 2004
  • ISBN
  • 9780851998213
  • Record Number
  • 20043136080