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CABI Book Chapter

Parasitic nematodes: molecular biology, biochemistry and immunology.

Book cover for Parasitic nematodes: molecular biology, biochemistry and immunology.


This book covers recent advances made in the genetics and biochemistry of nematodes, and the immunology of infections which have been made possible by new molecular genetic, biochemical and immunological tools. The topics covered include: molecular analysis of nematode evolution; Wolbachia endosymbionts of filarial nematodes; genetic analysis of plant-parasitic nematode-host interactions; identifi...


Chapter 18 (Page no: 373)

Gut immunopathology in helminth infections - paradigm lost?

This review illustrates the concepts of enteropathy and immune expulsion, and discusses the implications of this for understanding the process of immune expulsion of gut nematodes and the prospects for anti-nematode vaccines. The pathology of nematode infections and nematode expulsion are presented, and compared to enteropathies that occur as a result of other aetiologies. This chapter also elaborates on the role of tumour necrosis factor, matrix metalloproteases, and effector and goblet cells, as well as host microbial flora, in enteropathies, and discusses Th2 cytokine involvement in pathological responses to helminth infections. The potential benefits that these gastrointestinal parasites may acquire, such as increased generation of the next life cycle stage, as a result of the consequent pathological response of the host to infection, are presented.

Other chapters from this book

Chapter: 1 (Page no: 1) Molecular analysis of nematode evolution. Author(s): Blaxter, M. L.
Chapter: 2 (Page no: 25) The Wolbachia endosymbionts of filarial nematodes. Author(s): Bandi, C. Anderson, T. J. C. Genchi, C. Blaxter, M. L.
Chapter: 3 (Page no: 45) Forward genetic analysis of plant-parasitic nematode-host interactions. Author(s): Opperman, C. H.
Chapter: 4 (Page no: 53) Identification of parasitic nematodes and study of genetic variability using PCR approaches. Author(s): Gasser, R. B.
Chapter: 5 (Page no: 83) Diversity in populations of parasitic nematodes and its significance. Author(s): Viney, M. E.
Chapter: 6 (Page no: 103) New insights into the intestinal niche of Trichinella spiralis. Author(s): Appleton, J. A.
Chapter: 7 (Page no: 121) Genetic reprogramming of mammalian skeletal muscle cells by Trichinella spiralis. Author(s): Jasmer, D. P.
Chapter: 8 (Page no: 139) Plant-parasitic nematodes. Author(s): Bird, D. M. Bird, A. F.
Chapter: 9 (Page no: 167) The nematode cuticle: synthesis, modification and mutants. Author(s): Page, A. P.
Chapter: 10 (Page no: 195) Chitinases of filarial nematodes. Author(s): Adam, R. Drabner, B. Lucius, R.
Chapter: 11 (Page no: 211) Acetylcholinesterase secretion by nematodes. Author(s): Selkirk, M. E. Henson, S. M. Russell, W. S. Hussein, A. S.
Chapter: 12 (Page no: 229) The surface and secreted antigens of Toxocara canis: genes, protein structure and function. Author(s): Maizels, R. M. Loukas, A.
Chapter: 13 (Page no: 247) Nematode gut peptidases, proteins and vaccination. Author(s): Knox, D. P. Skuce, P. J. Newlands, G. F. Redmond, D. L.
Chapter: 14 (Page no: 269) Metabolic transitions and the role of the pyruvate dehydrogenase complex during development of Ascaris suum. Author(s): Komuniecki, R. Komuniecki, P. R.
Chapter: 15 (Page no: 285) Novel carbohydrate structures. Author(s): Dell, A. Haslam, S. M. Morris, H. R.
Chapter: 16 (Page no: 309) Structurally novel lipid-binding proteins. Author(s): Kennedy, M. W.
Chapter: 17 (Page no: 331) T helper cell cytokine responses during intestinal nematode infection: induction, regulation and effector function. Author(s): Artis, D. Grencis, R. K.
Chapter: 19 (Page no: 399) Immunomodulation by filarial nematode phosphorylcholine-containing glycoproteins. Author(s): Harnett, W. Harnett, M. M.
Chapter: 20 (Page no: 415) Nematode neuropeptides. Author(s): Maule, A. G. Marks, N. J. Halton, D. W.
Chapter: 21 (Page no: 441) Neurobiology of nematode muscle: ligand-gated ion-channels and anti-parasitic drugs. Author(s): Martin, R. J. Robertson, A. P. Valkanov, M. A. Purcell, J. Lowden, C. S.

Chapter details