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The functional region (reactive centre) of serine protease inhibitors is near the carboxyl-terminal end, and is an exposed site that acts as a "bait" for the appropriate serine protease to recognise and covalently bind. The specificity of the inhibitor is determined, at least in part, by a single...

Hill, R. E.; Hastie, N. D.
Nature, UK, 1987, 326, 6108, pp 96-99