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Abstract

Tumour necrosis factor (TNF)-α is an important human cytokine that imparts dualism in malaria pathogenicity. At high dosages, TNF-α is believed to provoke pathogenicity in cerebral malaria; while at lower dosages TNF-α is protective against severe human malaria. To understand the human TNF-α gene...

Author(s)
Gauri Awasthi; Suchita Singh; Dash, A. P.; Aparup Das
Publisher
Contexto, Bahia, Brazil
Citation
Brazilian Journal of Infectious Diseases, 2008, 12, 5, pp 374-379
Abstract

The functional region (reactive centre) of serine protease inhibitors is near the carboxyl-terminal end, and is an exposed site that acts as a "bait" for the appropriate serine protease to recognise and covalently bind. The specificity of the inhibitor is determined, at least in part, by a single...

Author(s)
Hill, R. E.; Hastie, N. D.
Citation
Nature, UK, 1987, 326, 6108, pp 96-99